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Thakur Tanika Gandass Nishu Mittal Kajal Jamwal Pallavi Muthamilarasan Mehanathan Salvi Prafull 《Functional & integrative genomics》2021,21(5-6):593-603
Functional & Integrative Genomics - Proteins regulate cellular and biological processes in all living organisms. More than 80% of the proteins interact with one another to perform their... 相似文献
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Community outbreak of Yersinia pseudotuberculosis 总被引:4,自引:0,他引:4
M Inoue H Nakashima O Ueba T Ishida H Date S Kobashi K Takagi T Nishu M Tsubokura 《Microbiology and immunology》1984,28(8):883-891
An outbreak of Yersinia pseudotuberculosis in Kurashiki, Japan is described. This is the first conclusive report of a community outbreak of this microorganism. A total of 535 pupils, five teachers, and one food attendant contracted the organism. Causative organisms were detected in 19 out of 30 patients. All isolated strains belonged to serotype VA. Out of 653 sera of the pupils, 488 showed elevated agglutinin titers ranging from 1:80 to 1:1,280 or more within a period of 3 months. 相似文献
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Rajiv Sharma Ravindra K. Rawal Tripti Gaba Nishu Singla Manav Malhotra Sahil Matharoo T.R. Bhardwaj 《Bioorganic & medicinal chemistry letters》2013,23(19):5332-5338
Colon-specific azo based prodrugs of anticancer agents like methotrexate (6), gemcitabine (7) and analogue of oxaliplatin (RTB-4) (8) were synthesized and characterized by modern analytical techniques. The prepared prodrugs were stable in acidic (pH 1.2) and basic (pH 7.4) buffers which showed their stability in upper GIT environment. Further, an assay was performed which demonstrated the presence of azoreductase enzyme in the rat fecal material, rat cecum content and other parts of intestinal content which reduce specifically the azo bond and release the drug. The in vitro cytotoxicity assay was also performed which clearly indicated that these azo based prodrugs are active against human colorectal cancer cell lines (COLO 205, COLO 320 DM and HT-29). The release behavior of prodrugs (10, 11 and 15) was 60–70% after 24 h incubation at 37 °C. Therefore, the synthesized azo linked prodrugs of methotrexate, gemcitabine and RTB-4 are the potential candidates for colon targeted drug delivery system with minimal undesirable side effects. 相似文献
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