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1.
Naumova E. V. Vladimirov Yu. A. Beloussov L. V. Tuchin V. V. Volodyaev I. V. 《Biophysics》2021,66(5):764-778
Biophysics - This review is devoted to the methods for studying the ultraweak luminescence of biological objects; in addition to modern methods aimed at studies in the visible, near-infrared, and... 相似文献
2.
Iu A Vladimirov 《Biofizika》1987,32(5):830-844
The results obtained mainly by the author and coworkers are summarized. One efficient method to detect free radicals in biological samples is chemiluminescence (CL). In the absence of activators CL of membraneous systems is due to lipid peroxide free radicals, whereas in the presence of luminol it is initiated by oxygen radicals. Low levels of free radicals in the cells and blood plasma are maintained by antioxidants, enzymes included. Ferrous ions increase free radical concentrations in the cells and tissues. Deleterious action of hydroxyl radicals is the result of the breakage of DNA strains and of lipid peroxidation (LPO). The latter reaction brings about the damage of the membrane barriers due to a decrease of the electrical stability of the membrane lipid bilayer and "self-breakdown" of the membranes by potential differences produced in the living cells. 相似文献
3.
Cyclic nucleotide content of plasma was shown to increase after irradiation of mice within a wide range of doses. Compared was the dynamics of changes in the cyclic nucleotide content 24 hr following irradiation with supralethal doses. 相似文献
4.
P G Chistyakov M N Abdukayumov A G Veniaminova S N Vladimirov D M Graifer S A Kazakov G G Karpova 《FEBS letters》1988,236(1):246-250
The cleavable homobifunctional reagent dichloro[N,N,N',N'-tetrakis(2-aminoethyl)-1,6-hexamethylenediamminedi platinum (II)] dichloride was used for studying rRNA-protein cross-links in free 35S-labelled 70 S ribosomes and within initiation complex ribosome.AUGU6.fMet-tRNA(fMet). It was shown that the sets of proteins cross-linked to 16 S and 23 S rRNA in free 70 S ribosomes and in 70 S initiation complex do not differ significantly. The authors are the first to demonstrate most of the 23 S rRNA-protein cross-links and some 16 S rRNA-protein cross-links, in particular those with L7/L12 protein. 相似文献
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6.
O A Azizova O M Panasenko T V Vol'nova Y A Vladimirov 《Free radical biology & medicine》1989,7(3):251-257
Human erythrocytes were incubated for 5 h at 37 degrees C with lipoproteins (LP), preliminary oxidized to different extent, as assessed by thiobarbituric acid (TBA) test. Cholesterol content in the cells was increased by 12-14% after incubation with low-density lipoproteins (LDL) along with augmentation of order parameter and rotational correlation time of spin-labeled stearic acids incorporated into membranes. If erythrocytes were incubated with oxidized LDL, containing 2.5-4 times more TBA-reactive material than native ones, cellular content of cholesterol was increased by 24-28%. In contrast, high-density lipoproteins (HDL2 and HDL3) removed cholesterol from cell membranes, when incubated with erythrocytes. This was followed by increased fluidity of membrane lipid phase as detected by the spin probe method. Oxidation of HDL2 and HDL3 decreased their ability to accept cholesterol from cell membranes. No detectable accumulation of TBA-reactive material was observed in the samples during the incubation. The antioxidant, butylated hydroxytoluene (BHT), in the concentration of 10(-5) M did not influence the cholesterol transfer between LP and erythrocytes. Hence, the effects of lipid peroxidation (LPO) on the cholesterol transfer seem to result from LP alterations by oxidation rather than from free radical reactions occurring during the incubation. By increasing cholesterol-donating ability of LDL and inhibition of cholesterol-accepting capacity of HDL lipid peroxidation in LP may activate cholesterol accumulation in blood vessel cells and thus contribute to atherosclerosis. 相似文献
7.
In experiments with albino mice, rats and guinea pigs the effect of ionizing radiation (100 Gy) on brain phospholipids and their fatty acids has been investigated. Upon the development of manifest behavioural disturbances (2 h after irradiation) phospholipid molecules degrade insignificantly. Some changes in the relative content of phospholipids and their fatty acids are mainly found in the rat synaptosomal fraction: this may be responsible for the disturbances in the sensitivity of the receptor apparatus of cell membranes. 相似文献
8.
Elena Driomina Igor Polnikov Victor Sharov Ofelia Azizova Yury Vladimirov 《Free radical research》1994,20(5):279-288
A chemiluminescence (CL) flash kinetics on the addition of Fe2+ ions into oxidized low density lipoprotein (LDL) suspension has been studied. LDL oxidation was carried out at 37°C without and in the presence of 5 or 50 μM of Cu.2+ It has been found that under certain experimental conditions (the addition of excess iron ions, more than 1 mM) the amplitude of CL flash depended almost linearly (1) on the concentration of oxidized LDL and (2) on the extent of LDL oxidation measured as diene conjugates (DC) and 2-thiobarbituric acid-reactive substance (TBARS) accumulation. The corresponding correlation coefficients were: for TBARS - 0.94 and for DC - 0.97, in the case of LDL autooxidation; 0.72 and 0.98, in the case of copper-induced LDL oxidation. A sensitivity of the CL method was shown to be significantly enhanced (by more than two orders) in the presence of CL sensitizer - 2, 3,5, 6-lH,4H-tetrahydro-9-(2' -benzoimidazolyl)-quinolizin-(9, 9a, 1 -gh)coumarin. 相似文献
9.
10.
Antioxidative and antiradical activity of the following typical inhibitors of free radical reactions were investigated in the model systems: ethanol, ionol, uric acid, superoxide dismutase, albumin. The antioxidative and antiradical activities of these inhibitors were shown to differ in various model systems. 相似文献