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排序方式: 共有86条查询结果,搜索用时 31 毫秒
1.
Chia-chen Chang Daniel T. C. Cox Qiao Fan Thi Phuong Le Nghiem Claudia L. Y. Tan Rachel Rui Ying Oh Brenda B. Lin Danielle F. Shanahan Richard A. Fuller Kevin J. Gaston L. Roman Carrasco 《PLoS biology》2022,20(2)
Nature experiences have been linked to mental and physical health. Despite the importance of understanding what determines individual variation in nature experience, the role of genes has been overlooked. Here, using a twin design (TwinsUK, number of individuals = 2,306), we investigate the genetic and environmental contributions to a person’s nature orientation, opportunity (living in less urbanized areas), and different dimensions of nature experience (frequency and duration of public nature space visits and frequency and duration of garden visits). We estimate moderate heritability of nature orientation (46%) and nature experiences (48% for frequency of public nature space visits, 34% for frequency of garden visits, and 38% for duration of garden visits) and show their genetic components partially overlap. We also find that the environmental influences on nature experiences are moderated by the level of urbanization of the home district. Our study demonstrates genetic contributions to individuals’ nature experiences, opening a new dimension for the study of human–nature interactions.Nature experiences have been linked to mental and physical health. This twin study reveals genetic influences on an individual’s orientation towards nature and nature experiences, opening a new dimension to understanding human-nature interactions. 相似文献
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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers 总被引:1,自引:0,他引:1
Zhang L Anglesio MS O'Sullivan M Zhang F Yang G Sarao R Mai PN Cronin S Hara H Melnyk N Li L Wada T Liu PP Farrar J Arceci RJ Sorensen PH Penninger JM 《Nature medicine》2007,13(9):1060-1069
Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 in mice results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increased tumor incidence in a Hace1-deficient background. Re-expression of HACE1 in human tumor cells directly abrogates in vitro and in vivo tumor growth, whereas downregulation of HACE1 via siRNA allows non-tumorigenic human cells to form tumors in vivo. Mechanistically, the tumor-suppressor function of HACE1 is dependent on its E3 ligase activity and HACE1 controls adhesion-dependent growth and cell cycle progression during cell stress through degradation of cyclin D1. Thus, HACE1 is a candidate chromosome 6q21 tumor-suppressor gene involved in multiple cancers. 相似文献
4.
Qiaoying Zhang Joanne Nghiem Gregory J. Silverberg Chad D. Vecitis 《Applied and environmental microbiology》2015,81(14):4744-4755
In this study, we examine bacterial attachment and survival on a titanium (Ti) cathode coated with various carbon nanomaterials (CNM): pristine carbon nanotubes (CNT), oxidized carbon nanotubes (O-CNT), oxidized-annealed carbon nanotubes (OA-CNT), carbon black (CB), and reduced graphene oxide (rGO). The carbon nanomaterials were dispersed in an isopropyl alcohol-Nafion solution and were then used to dip-coat a Ti substrate. Pseudomonas fluorescens was selected as the representative bacterium for environmental biofouling. Experiments in the absence of an electric potential indicate that increased nanoscale surface roughness and decreased hydrophobicity of the CNM coating decreased bacterial adhesion. The loss of bacterial viability on the noncharged CNM coatings ranged from 22% for CB to 67% for OA-CNT and was dependent on the CNM dimensions and surface chemistry. For electrochemical experiments, the total density and percentage of inactivation of the adherent bacteria were analyzed semiquantitatively as functions of electrode potential, current density, and hydrogen peroxide generation. Electrode potential and hydrogen peroxide generation were the dominant factors with regard to short-term (3-h) bacterial attachment and inactivation, respectively. Extended-time electrochemical experiments (12 h) indicated that in all cases, the density of total deposited bacteria increased almost linearly with time and that the rate of bacterial adhesion was decreased 8- to 10-fold when an electric potential was applied. In summary, this study provides a fundamental rationale for the selection of CNM as cathode coatings and electric potential to reduce microbial fouling. 相似文献
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Cowin RM Bui N Graham D Green JR Yuva-Paylor LA Weiss A Paylor R 《Mammalian genome》2012,23(5-6):367-377
Variability and modification of the symptoms of Huntington’s disease (HD) are commonly observed in both patient populations and animal models of the disease. Utilizing a stable line of the R6/2 HD mouse model, the present study investigated the role of genetic background in the onset and severity of HD symptoms in a transgenic mouse. R6/2 congenic C57BL/6J and C57BL/6J×DBA/2J F1 (B6D2F1) mice were evaluated for survival and a number of behavioral phenotypes. This study reports that the presence of the DBA/2J allele results in amelioration or exacerbation of several HD-like phenotypes characteristic of the R6/2 mouse model and indicates the presence of dominant genetic modifiers of HD symptoms. This study is the first step in identifying genes that confer natural genetic variation and modify the HD symptoms. This identification may lead to novel targets for treatment and help elucidate the molecular mechanisms of HD pathogenesis. 相似文献
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Human mononuclear phagocyte (M phi) populations were compared to adult human endothelial cells (HEC) for their respective abilities to influence the proliferative responses of purified human T lymphocytes to the mitogenic agents Na-m-periodate (IO-4), soybean agglutinin (SBA), or allogeneic cells. HEC and M phi were both capable of inducing proliferative responses of allogeneic T lymphocytes in mixed-lymphocyte culture. Under low cell density culture conditions, purified T-lymphocyte proliferative responses to IO-4 or SBA could be restored by addition of syngeneic M phi or HEC. At higher cell density culture conditions, proliferation of T cells to IO-4 could be amplified more by HEC than M phi. T-lymphocyte proliferative responses to SBA were amplified by addition of HEC but were suppressed by addition of M phi. These findings indicate that human adult HEC are unique and potent accessory cells for T lymphocytes. Furthermore, these findings demonstrate that accessory cell functions of HEC can be discriminated from those of M phi. 相似文献
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New species of Ophiopogon,Peliosanthes and Tupistra (Asparagaceae s.l.) in the flora of Vietnam
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Leonid V. Averyanov Noriyuki Тanaka Khang Sinh Nguyen Ba Vuong Truong Duc Trong Nghiem Tien Hiep Nguyen 《Nordic Journal of Botany》2016,34(1):23-37
Five new species named Peliosanthes aperta, P. elegans, P. kenhillii, Tupistra densiflora and T. patula are described and illustrated. These species are very local in distribution and endemic to northern or southern Vietnam. Two other species, Ophiopogon ogisui and Peliosanthes griffithii, are recorded as new to the flora of Vietnam. A key to the species of Tupistra occurring in Indochina and its neighboring regions is also provided. 相似文献
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Nghiem Peter P. Bello Luca Balog-Alvarez Cindy López Sara Mata Bettis Amanda Barnett Heather Hernandez Briana Schatzberg Scott J. Piercy Richard J. Kornegay Joe N. 《Mammalian genome》2017,28(3-4):106-113
Mammalian Genome - Dystrophin is a key cytoskeletal protein coded by the Duchenne muscular dystrophy (DMD) gene located on the X-chromosome. Truncating mutations in the DMD gene cause loss of... 相似文献