Distribution of HLA Antigens in the Armenian Population of Nagornyi Karabakh

Characteristics of the distribution of 31 HLA antigens of classes I (A, B, and Cw) and II (DR) in Nagornyi Karabakh Armenians are reported for the first time. It has been found that the antigens most common in this population are A2, A3, A9, B5, B7, B12, Cw4, DR4, DR2, and DR3; the least common antigens are B15, B16, and B40. The results are compared with the data for Armenians living in Armenia and those for major ethnic groups. The frequencies of HLA antigens in Nagornyi Karabakh Armenians match those in Armenians living in Armenia. In the HLA-antigen distribution, Armenians are generally close to Caucasoids.     

Excitation of growing wake waves by an electron bunch in a plasma in an intense pump wave

A study is made of the excitation of wake waves by a one-dimensional electron bunch in an electron plasma in the presence of an intense monochromatic pump wave with circular polarization. In the main state (in the absence of a bunch), the interaction between a pump wave and a plasma is described by Maxwell's equations and the nonlinear relativistic hydrodynamic equations for a cold plasma. The excitation of linear waves by a one-dimensional bunch is investigated against a cold plasma background. It is shown that, in a certain range of parameter values of the bunch, pump wave, and plasma, the excitation is resonant in character and the amplitude of the excited wake waves increases with distance from the bunch.     

Computel: Computation of Mean Telomere Length from Whole-Genome Next-Generation Sequencing Data

Telomeres are the ends of eukaryotic chromosomes, consisting of consecutive short repeats that protect chromosome ends from degradation. Telomeres shorten with each cell division, leading to replicative cell senescence. Deregulation of telomere length homeostasis is associated with the development of various age-related diseases and cancers. A number of experimental techniques exist for telomere length measurement; however, until recently, the absence of tools for extracting telomere lengths from high-throughput sequencing data has significantly obscured the association of telomere length with molecular processes in normal and diseased conditions. We have developed Computel, a program in R for computing mean telomere length from whole-genome next-generation sequencing data. Computel is open source, and is freely available at https://github.com/lilit-nersisyan/computel. It utilizes a short-read alignment-based approach and integrates various popular tools for sequencing data analysis. We validated it with synthetic and experimental data, and compared its performance with the previously available software. The results have shown that Computel outperforms existing software in accuracy, independence of results from sequencing conditions, stability against inherent sequencing errors, and better ability to distinguish pure telomeric sequences from interstitial telomeric repeats. By providing a highly reliable methodology for determining telomere lengths from whole-genome sequencing data, Computel should help to elucidate the role of telomeres in cellular health and disease.     

Effect of a strong monochromatic electromagnetic wave with circular polarization on one-dimensional wake waves in plasma

A study is made of the excitation of wake waves by a one-dimensional bunch of charged particles in an electron plasma in the presence of an intense monochromatic pump wave with circular polarization. In the main state (in the absence of a bunch), the interaction between a pump wave and a plasma is described by the Maxwell equations and the nonlinear relativistic hydrodynamic equations for a cold plasma. The excitation of linear waves by a one-dimensional bunch is investigated against a cold plasma background. It is shown that, in a certain range of the parameter values of the bunch, pump wave, and plasma, the amplitude of the excited transverse waves grows as the energy of the bunch particles increases until the relativistic factor of the bunch reaches a certain threshold value above which the transverse wave amplitude becomes essentially independent of the bunch particle energy and grows as the intensity and frequency of the pump wave increase. The amplitude and wavelength of the longitudinal field, which is shown to depend weakly on the energy of the bunch particles, grows with increasing the pump wave intensity.