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The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels 总被引:2,自引:0,他引:2
This study was designed to examine the effects of intracerebroventricular injection of DL-AP5 (N-methyl-D-aspartate (NMDA) receptor antagonist) and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived (FD3) broiler
cockerels. At first, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds
were intracerebroventricularly injected with 0, 2.5, 5, and 10 nmol of DL-AP5. In experiment 2, chickens received 5 nmol DL-AP5
prior to the injection of 0.6 nmol ghrelin. In experiment 3, birds were administered with 0.6 nmol ghrelin after 300 nmol
glutamate, and the cumulative feed intake was determined at 3-h postinjection. The results of this study showed that the intracerebroventricular
injection of DL-AP5 increased food consumption in FD3 broiler cockerels (P ≤ 0.05), and this increase occurs in a dose-dependent manner. Moreover, the decreased food intake induced with the intracerebroventricular
injection of ghrelin was additively enhanced by pretreatment with glutamate, and this effect was attenuated by DL-AP5 administration(P ≤ 0.05).These results suggest that there is an interaction between ghrelin and glutamatergic system (through NMDA receptor)
on food intake in broiler cockerels. 相似文献
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Nayebzadeh Neda Vazir Bita Zendehdel Morteza Asghari Ahamd 《International journal of peptide research and therapeutics》2020,26(1):1-10
International Journal of Peptide Research and Therapeutics - The aim of the current study was to determine possible interaction of central Opioidergic and Adrenergic systems on food intake... 相似文献
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