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Maryam Ebrahimi Nik Amir Abbas Momtazi-Borojeni Parvin Zamani Jamshid Gholizadeh Navashenaq Mehrdad Iranshahi Mahmoud Reza Jaafari Bizhan Malaekeh-Nikouei 《Journal of cellular physiology》2019,234(9):14721-14733
A number of antiangiogenic drugs have been approved by the Food and Drug Administration which are used in cancer therapy, and variety of other agents in several stages of clinical development or in preclinical assessment. Among these, combretastatin A4 (CA-4) is an under-researched inhibitor of angiogenesis that shows potential activity in the treatment of advanced tumors with migration capacity. However, its clinical application has been limited due to poor water solubility, low bioavailability, rapid metabolism, and systemic elimination. During the last decade, numerous investigations have been done to overcome these problems by using different CA-4 delivery systems or developing produgs of CA-4 or its structural analogs. Nevertheless, these strategies could not be efficient out of the undesired side effects on normal tissues. Nanoliposomal CA-4 not only benefits from the advantage of using liposomal drugs as opposed to free drugs but also can accumulate in the tumor site via specific targeting ligands, which leads to efficient targeting and enhancement of bioavailability. To the best of our knowledge, we consider an important attempt to understand different factors that might influence the CA-4 loading and release pattern of liposomes and the consequent results in tumor therapy. In this review, we shed light on various studied liposomal CA-4 formulations showing application thereof in cancer treatment. 相似文献
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Naseh Pahlavani Fatemeh Roudi Mohsen Zakerian Gordon A Ferns Jamshid Gholizadeh Navashenaq Amir Mashkouri Majid Ghayour-Mobarhan Hamidreza Rahimi 《Journal of cellular biochemistry》2019,120(7):10921-10929
Diabetes mellitus is a highly prevalent metabolic disorder which is characterized by impaired glucose tolerance, with a relative or absolute insulin deficiency and profound changes in the metabolism of macronutrients. Traditional and complementary medicine is therapeutic strategies that have both been applied to improving glycemic control. Momordica charantia is one of the plant-based, folk medicines that used for improving glycemic control. We aimed to review, the effects of M. charantia on blood glucose with a clarification of the molecular pathways involved. Of the compounds derived from the plants, the insulin-like peptide, charantin, and the alkaloid vicine, have been reported to have hypoglycemic effects. Different mechanisms contribute to the antidiabetic activities of M. charantia, these include increasing pancreatic insulin secretion, decreasing insulin resistance and increasing peripheral and skeletal muscle cell glucose utilization, inhibition of intestinal glucose absorption and suppressing of key enzymes in the gluconeogenic pathways. 相似文献
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Navashenaq Jamshid Gholizadeh Shabgah Arezoo Gowhari Hashemi Esmat Alsadat Seyedzadeh Mir Hadi Shokri Fazel Razavi Seyed Alireza Kardar Gholam Ali 《International journal of peptide research and therapeutics》2019,25(2):413-418
International Journal of Peptide Research and Therapeutics - Tumor cells in breast cancer are immunogenic and express proteins that can induce immune responses. One important antigen is human... 相似文献
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