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Karabulut Uzunçakmak Sevgi Naldan Muhammet Emin Dirican Ebubekir Kerget Ferhan Halıcı Zekai 《Molecular biology reports》2022,49(9):8693-8699
Molecular Biology Reports - Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and... 相似文献
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Mesut Işık Abdullah Tunç Hatice Esra Duran Muhammet Emin Naldan Aslan Yılmaz Mehmet Nuri Koçak Şükrü Beydemir 《Journal of cellular and molecular medicine》2023,27(21):3388-3394
It is known that oxidative stress originating from reactive oxygen species plays a role in the pathogenesis of Alzheimer's disease. In this study, the role of antioxidant status associated with oxidative stress in Alzheimer's disease was investigated. Peripheral blood samples were obtained from 28 healthy individuals (as control) and 28 Alzheimer's patients who met the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria. Catalase, glutathione S-transferase and paraoxonase 1 enzyme activities in blood plasma and glutathione S-transferase enzyme activities in erythrocytes were determined by spectrophotometer. Catalase, glutathione S-transferase and presenilin 1 gene expressions in leukocytes were determined using qRT-PCR. Data were analysed with SPSS one-way anova , a LSD post hoc test at p < 0.05. The activity of each enzyme was significantly reduced in Alzheimer's patients compared to control. The catalase gene expression level did not change compared to the control. Glutathione S-transferase and presenilin 1 gene expression levels were increased compared to the control. 相似文献
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