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Brodsky V. Y. Zolotarev Y. A. Malchenko L. A. Andreeva L. A. Lazarev D. S. Butorina N. N. Kozik V. S. Myasoedov N. F. 《Russian Journal of Developmental Biology》2020,51(2):99-105
Russian Journal of Developmental Biology - To clarify the organizing effect of Semax and HLDF-6 peptides on the kinetics of protein synthesis in hepatocytes, in addition to an in vitro study... 相似文献
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Zolotarev Yu. A. Dadayan A. K. Kozik V. S. Nagaev I. Yu. Azev V. N. Gorbunova E. Yu. Mustaeva L. G. Bogachouk A. P. Lipkin V. M. Myasoedov N. F. 《Russian Journal of Bioorganic Chemistry》2020,46(6):1044-1051
Russian Journal of Bioorganic Chemistry - The HLDF-6 hexapeptide corresponded to the 41–46 (TGENHR) fragment of the Human Leukemia Differentiation Factor (HLDF) and exhibited a wide spectrum... 相似文献
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N. F. Myasoedov L. A. Andreeva L. A. Lyapina T. A. Shubina M. E. Grigor’eva T. Yu. Obergan 《Biology Bulletin》2013,40(3):304-306
It has been established that fivefold intranasal administration of the peptide Leu-Pro-Gly-Pro (1 mg/kg) to rats with developing refractory hyperglycemia leads to restoration and normalization of the functions of anticoagulation and insular systems. In the blood of experimental animals, there was a decrease in the sugar level and platelet aggregation and an increase in anticoagulant and all kinds of fibrinolytic (total, enzymatic, non-enzymatic, Hageman-dependent) activity. 相似文献
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Zolotarev Yu. A. Dadayan A. K. Kozik V. S. Shram S. I. Azev V. N. Bogachouk A. P. Lipkin V. M. Myasoedov N. F. 《Russian Journal of Bioorganic Chemistry》2019,45(6):514-521
Russian Journal of Bioorganic Chemistry - Pharmacokinetics of the promising antitumor peptide HLDF-6-AA (Ac-ThrGlyGluAsnHisArg-NH2) was studied using its uniformly tritiated derivative. Experiments... 相似文献
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Voronin P. Yu. Ivanova L. A. Ronzhina D. A. Myasoedov N. A. Balnokin Yu. V. 《Russian Journal of Plant Physiology》2019,66(5):707-711
Russian Journal of Plant Physiology - The data concerning morphometric characterization of chloroplasts belonging to two groups of halophytes distinguished by their salt... 相似文献
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Summary. No influence of isotopic substitution in deuterium-substituted tryptophan on the florescence excitation spectrum has previously
been found out. Here, the isotopic effects of electronic excitation of deuterium-substituted tryptophan were experimentally
and theoretically analyzed for first time. It was shown a short-wave shift of the UV-absorption maximum at 220 nm corresponding
to the 360 cal/mol and short-wave shift for fluorescence spectrum corresponding to the 210 cal/mol. To account for this effect,
the quantum chemical calculations of the geometric and electron structure, frequencies of normal vibrations and transition
energies have been performed. The isotopic effects originate from the zero-point energies of ground and excited states. It
was found that isotopic shifts depend on the position of isotope in the molecule and kind of transition. So, it can be utilized
in the analysis of proteins structure and complexation. 相似文献
9.
T. V. Ivanova O. V. Maiorova Yu. V. Orlova E. I. Kuznetsova L. A. Khalilova N. A. Myasoedov Yu. V. Balnokin V. D. Tsydendambaev 《Russian Journal of Plant Physiology》2016,63(6):763-775
White goosefoot plants (Chenopodium album L. of the family Chenopodiaceae) grown at various NaCl concentrations (3–350 mM) in the nutrient solution were used to study the cell ultrastructure as well as the qualitative and quantitative composition of fatty acids in the lipids of vegetative organs. In addition, the biomass of Ch. album vegetative organs, the water content, and the concentrations of K+, Na+, and Cl– were determined. The growth rates of plants raised at NaCl concentrations up to 200–250 mM were the same as for the control plants grown at 3 mM NaCl; the growth parameters remained rather high even at NaCl concentrations of 300–350 mM. The water content in Ch. album organs remained high at all NaCl concentrations tested. Analysis of the ionic status of Ch. album revealed a comparatively high K+ content in plant organs. At low NaCl concentrations in the nutrient solution, K+ ions were the dominant contributors to the osmolarity (the total concentration of osmotically active substances) and, consequently, to the lowered cell water potential in leaves and roots. As the concentration of NaCl was increased, the plant organs accumulated larger amounts of Na+ and Cl–, and the contribution of these ion species to osmolarity became increasingly noticeable. At 300–350 mM NaCl the contribution of Na+ and Cl– to osmolarity was comparable to that of K+. An electron microscopy study of Ch. album cells revealed that, apart from the usual response to salinity manifested in typical ultrastructural changes of chloroplasts, mitochondria, and the cytosol, the salinity response comprised the enhanced formation of endocytic structures and exosomes and stimulation of autophagy. It is supposed that activation of these processes is related to the removal from the cytoplasm of toxic substances and the cell structures impaired by salt stress conditions. The qualitative and quantitative composition of fatty acids in the lipids of Ch. album organs was hardly affected by NaCl level. These findings are consistent with the high salt tolerance of Ch. album, manifested specifically in retention of growth functions under wide-range variations of NaCl concentration in the nutrient solution and in maintenance of K+, Na+, and Cl– content in organs at a constant level characteristic of untreated plants. 相似文献
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Yu. V. Balnokin N. A. Myasoedov Z. Sh. Shamsutdinov N. Z. Shamsutdinov 《Russian Journal of Plant Physiology》2005,52(6):779-787
The contents of Na+, K+, water, and dry matter were measured in leaves and roots of euhalophytes Salicornia europaea L. and Climacoptera lanata (Pall.) Botsch featuring succulent and xeromorphic cell structures, respectively, as well as in saltbush Atriplex micrantha C.A. Mey, a halophyte having bladder-like salt glands on their leaves. All three species were able to accumulate Na+ in their tissues. The Na+ content in organs increased with elevation of NaCl concentration in the substrate, the concentrations of Na+ being higher in leaves than in roots. When these halophytes were grown on a NaCl-free substrate, a trend toward K+ accumulation was observed and was better pronounced in leaves than in roots. Particularly high K+ concentrations were accumulated in Salicornia leaves. There were no principal differences in the partitioning of Na+ and K+ between organs of three halophyte species representing different ecological groups. At all substrate concentrations of NaCl, the total content of Na+ and K+ in leaves was higher than in roots. This distribution pattern persisted in Atriplex possessing salt glands, as well as in euhalophytes Salicornia and Climacoptera. The physiological significance of such universal pattern of ion accumulation and distribution among organs in halophytes is related to the necessity of water absorption by roots, its transport to shoots, and maintenance of sufficient cell water content in all organs under high soil salinity. 相似文献