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(Ca2+ or Mg2+)-ATPase in lung lamellar bodies 总被引:1,自引:0,他引:1
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Ashwini Kumar M. M. Husain Hasan Mukhtar C. R. Krishna Murti 《Journal of biosciences》1980,2(3):181-189
Glutathione-S-transferase (EC 2.5.1.18) activity was assayed in hepatic and extra-hepatic tissues of pigeons using l-chloro-2,4-dinitrobenzene
and 1,2-dichloro-4-nitrobenzene as substrates. Gluthathione-S-transferase activity towards 1-chloro-2,4-dinitrobenzene in
pigeon was in the order: kidney > liver > testes > brain > lung> heart. The enzyme activity with 1-chloro-2,4-dinitrobenzene
as substrate was 40–44 times higher in pigeon liver and kidney than that observed with 1,2-dichloro-4-dinitrobenzene as substrate.K
m values of hepatic and renal glutathione transferase with l-chloro-2,4-dinitrobenzene as substrate were 2.5 and 3 mM respectively.
Double reciprocal plots with varying reduced gluthathione concentrations resulted in biphasic curves with twoK
m values (liver 0.31 mM and 4mM; kidney 0.36 mM and 1.3 mM). The enzyme activity was inhibited by oxidized gluthathione in
a dose-dependent pattern. 3-Methylcholanthrene elicited about 50% induction of hepatic glutathione transferase activity whereas
phénobarbital was ineffective. 相似文献
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The purpose of this study was to determine the factors that influence fill weight and weight variability of capsules produced
on the In-Cap and to assess any differences in terms of capsule defects between gelatin and HPMC (Quali-V) shells. The In-Cap
is an automatic tamping type capsule-filling machine and the low output of ≈3000 capsules/hour makes it ideal for early formulation
development and phase I/IIa clinical supplies manufacture. Four commonly used excipients (Avicel PH101, Avicel PH302, A-Tab,
and Prosolv HD90) and a poorly flowing drug blend were encapsulated at various pin settings and powder bed heights. The average
fill weight and coefficient of weight variation were determined. The percentage of defective capsules formed during encapsulation
was calculated. Results of the study showed that pin setting was critical for controlling the fill weight and the weight variation.
The order of pin setting with pin 1 (closer to the powder chute) set to a relatively higher position and pin 4 (before ejection)
set to a lower position was found to give higher fill weights with relatively lower weight variability. The powder bed height
influenced the fill weight for poorly flowing powders. The capsule machine speed did not appear to significantly influence
the fill weight. The fill weight and weight variation were found to depend on the flow property of the material. A large percentage
of defective capsules was obtained using HPMC shell size #00. Some of the commonly observed defects included split caps and
improperly closed filled capsules. In general, appropriate selection of pin settings and bed height can reduce the weight
variability seen, especially with poorly flowing high-dose formulations. 相似文献
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