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Ersen Eraslan Ayhan Tanyeli Elif Polat Elif Polat 《Journal of cellular physiology》2019,234(4):4572-4581
The transient receptor potential melastatin-2 (TRPM2) channel belongs to the transient receptor potential channel superfamily and is a cation channel permeable to Na+ and Ca 2+. The TRPM2 ion channel is expressed in the kidney and can be activated by various molecules such as hydrogen peroxide, calcium, and cyclic adenosine diphosphate (ADP)-ribose (cADPR) that are produced during acute kidney injury. In this study, we investigated the role of 8-bromo-cyclic ADP-ribose (8-Br-cADPR; a cADPR antagonist) in renal ischemia–reperfusion injury using biochemical and histopathological parameters. CD38, cADPR, tumor necrosis factor-α, interleukin-1β, and myeloperoxidase (inflammatory markers), urea and creatinine, hydrogen peroxide (oxidant), and catalase (antioxidant enzyme) levels that increase with ischemia–reperfusion injury decreased in the groups treated with 8-Br-cADPR. In addition, renin levels were elevated in the groups treated with 8-Br-cADPR. Histopathological examination revealed that 8-Br-cADPR reduced renal damage and the expression of caspase-3 and TRPM2. Our results suggest that the inhibition of TRPM2 ion channel may be a new treatment modality for ischemic acute kidney injury. 相似文献
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Gunes A Inal A Alpaslan M Eraslan F Bagci EG Cicek N 《Journal of plant physiology》2007,164(6):728-736
It has been proposed that salicylic acid (SA) acts as an endogenous signal molecule responsible for inducing abiotic stress tolerance in plants. The effect of varying salicylic acid (SA) supply (0, 0.1, 0.5 and 1.0mM) on growth, mineral uptake, membrane permeability, lipid peroxidation, H(2)O(2) concentration, UV-absorbing substances, chlorophyll and carotenoid concentrations of NaCl (40 mM) stressed maize (Zea mays L.) was investigated. Exogenously applied SA increased plant growth significantly both in saline and non-saline conditions. As a consequence of salinity stress, lipid peroxidation, measured in terms of malondialdehyde (MDA) content and membrane permeability was decreased by SA. UV-absorbing substances (UVAS) and H(2)O(2) concentration were increased by increasing levels of SA. SA also strongly inhibited Na(+) and Cl(-) accumulation, but stimulated N, Mg, Fe, Mn and Cu concentrations of salt stressed maize plants. These results suggest that SA could be used as a potential growth regulator to improve plant salinity stress resistance. 相似文献
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Yasin Eren Sevim Feyza Erdoğmuş Dilek Akyıl Arzu Özkara Muhsin Konuk Esra Sağlam 《Cytotechnology》2015,67(6):1023-1030
Dioxacarb (Elecron, Famid) is a phenyl methylcarbamate insecticide and in vitro cytotoxic and genotoxic effects of this pesticide on human peripheral blood lymphocytes and Allium root meristematic cells were investigated by chromosomal aberrations (CAs) and Allium test. Human lymphocytes were treated with 62.5, 125, 250 and 500 ppm doses of dioxacarb for CAs. CA/cell, abnormal cell % and mitotic index % (MI %) data were obtained from these concentrations in 24 and 48 h treatment periods. Dioxacarb did not increase the CA/cell frequency significantly, so this insecticide was not identified as genotoxic. But it was found cytotoxic especially at 250 and 500 ppm concentrations because of the reduced the MI % and increased the abnormal cell %. In Allium test, 25 ppm (EC50/2), 50 ppm (EC50) and 100 ppm (EC50 × 2) concentrations were used for root growth inhibition (EC50 determination) and Allium mitotic index (MI) determination tests. The used concentrations of dioxacarb induced dose-dependent inhibition of MI and root growth on root meristems. Mitotic inhibition of dioxacarb was found significantly higher than for the positive control. These Allium results indicated the high cytotoxicity of dioxacarb. The present study is the first research on cytotoxicity and genotoxicity of dioxacarb by human lymphocyte CAs and Allium test. 相似文献
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We investigated individual and combined effects of salinity, soil boron (B), silicon (Si) and salicylic acid (SA) on the activities
of major antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT and ascorbate peroxidase, APX) and non-enzymatic antioxidants
(AA), proline, chlorophyll, anthocyanin, H2O2 concentration, stomatal resistance (SR), lipid peroxidation (MDA), membrane permeability (MP), and the uptake of sodium (Na),
chloride (Cl), boron and Si of spinach plants. In general, salinity significantly increased H2O2 and proline concentrations, antioxidant activity, membrane permeability, lipid peroxidation and SR of the spinach plants,
indicating that they were stressed, whereas application of B only increased proline concentration. However, plant fresh weights
did not decline with either treatment. The application of Si decreased H2O2 and increased the activity of SOD and CAT. The application of SA increased SOD activity. Neither SA nor Si had any effect
on the proline concentration, or MP. However, application of Si increased chlorophyll concentration and decreased lipid peroxidation
(MDA concentration). Si treatment had no effect on SR. The concentration of B in the tissues, which was strongly increased
by B treatment, was decreased by NaCl. As a result of salinity, concentrations of Na+ and Cl− ions were increased in the plant tissues, and application of Si slightly increased these concentrations. These results indicate
that exogenous Si application increases stress tolerance of spinach, a plant that is naturally reasonably resistant to combined
salinity and B toxicity, by the enhancement of antioxidant mechanisms that reduce membrane damage. Exogenous SA has a less
obvious effect, although the levels of salinity and boron stress applied were not sufficient in this experiment to reduce
plant fresh weight. 相似文献
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Johannes F. Scheid Christopher O. Barnes Basak Eraslan Andrew Hudak Jennifer R. Keeffe Lisa A. Cosimi Eric M. Brown Frauke Muecksch Yiska Weisblum Shuting Zhang Toni Delorey Ann E. Woolley Fadi Ghantous Sung-Moo Park Devan Phillips Betsabeh Tusi Kathryn E. Huey-Tubman Alexander A. Cohen Ramnik J. Xavier 《Cell》2021,184(12):3205-3221.e24
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ZKAN OKTAY Salih TUNCAY Tuba KAMAN
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ZCAN Tue SOYLAMI Mesut KARAHAN Muhsin KONUK 《Turkish Journal of Biology》2021,45(4):342
Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B 1.351, P.1, and B.1.617 lineages or variants of concern that have been reported worldwide, the new manifestations of neurological manifestations, the current therapeutic drug targets for its treatment, vaccine candidates and their efficacy, implantation of convalescent plasma, and neutralization of mAbs. We review specific clinical questions, including many emerging neurological effects and respiratory tract injuries, as well as new potential biomarkers, new studies in addition to known therapeutics, and chronic diseases of vaccines that have received immediate approval. To answer these questions, further understanding of the burden kinetics of COVID-19 and its correlation with neurological clinical outcomes, endogenous antibody responses to vaccines, pharmacokinetics of neutralizing mAbs, and action against emerging viral mutant variants is needed. 相似文献
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Mustafa Cemek Mehmet Emin Büyükokuroğlu Ömer Hazman Muhsin Konuk Sait Bulut Yavuz Osman Birdane 《Biological trace element research》2011,142(1):55-66
The therapeutic effects of melatonin or vitamin E plus Se (vE + Se) on the restrain of the heroin withdrawal-induced oxidative
stress were studied. For this, rats were divided into ten groups. The rats were injected by fixed or variable doses of heroin
for 16 consecutive days, and naloxone was given 1 h after the last heroin injection. One hour after naloxone administration,
some groups were treated with melatonin or vE + Se. After 1 h this, blood samples were taken, and the levels of malondialdehyde
(MDA) and reduced glutathione (GSH) in whole blood, ascorbic acid, α-tocopherol, retinol, β-carotene, nitrite, nitrate, and
ceruloplasmin levels in the serum were measured. Our findings showed that, naloxone administration precipitated the heroin
withdrawal. This also increased the level of MDA and decreased the levels of GSH in blood. Melatonin or vE + Se administration
prevented the rise in MDA levels and increased the GSH levels. On the other hand, there were some significant differences
between α-tocopherol, retinol, β-carotene, nitrite, nitrate, and ceruloplasmin levels of experimental groups. Results of present
study showed that heroin withdrawal increased the lipid peroxidation and depressed endogenous antioxidative systems. Additionally,
melatonin or vE + Se administrations prevented lipid peroxidation and augmented endogenous antioxidant defense systems. 相似文献
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Süleyman?Ar? Mehmet?Temel Mustafa?Karg?o?lu Muhsin?KonukEmail authorView authors OrcID profile 《Journal of ethnobiology and ethnomedicine》2015,11(1):84