排序方式: 共有14条查询结果,搜索用时 31 毫秒
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Livia Garzia Noriyuki Kijima A. Sorana Morrissy Pasqualino De Antonellis Ana Guerreiro-Stucklin Borja L. Holgado Xiaochong Wu Xin Wang Michael Parsons Kory Zayne Alex Manno Claudia Kuzan-Fischer Carolina Nor Laura K. Donovan Jessica Liu Lei Qin Alexandra Garancher Kun-Wei Liu Michael D. Taylor 《Cell》2018,172(5):1050-1062.e14
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Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma 总被引:1,自引:0,他引:1
Daniel J. Merk Jasmin Ohli Natalie D. Merk Venu Thatikonda Sorana Morrissy Melanie Schoof Susanne N. Schmid Luke Harrison Severin Filser Julia Ahlfeld Serap Erkek Kaamini Raithatha Thomas Andreska Marc Weißhaar Michael Launspach Julia E. Neumann Mehdi Shakarami Dennis Plenker Ulrich Schüller 《Developmental cell》2018,44(6):709-724.e6
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Peter Daniels Bagoes Poermadjaja Chris Morrissy Thanh Long Ngo Paul Selleck Wantanee Kalpravidh John Weaver Frank Wong Mia Kim Torchetti John Allen Parwin Padungtod Andrew Davis Sanipa Suradhat Subhash Morzaria 《EcoHealth》2014,11(1):44-49
The outbreak of highly pathogenic H5N1 avian influenza, with its international spread, confirmed that emerging infectious disease control must be underpinned by effective laboratory services. Laboratory results are the essential data underpinning effective surveillance, case diagnosis, or monitoring of responses. Importantly, laboratories are best managed within national and international networks of technological support rather than in isolation. A well planned laboratory network can deliver both a geographical spread of testing capacity and also a cost effective hierarchy of capability. Hence in the international context regional networks can be particularly effective. Laboratories are an integral part of a country’s veterinary services and their role and function should be clearly defined in the national animal health strategy and supporting government policies. Not every laboratory should be expected to deliver every possible service, and integration into regional and broader international networks should be a part of the overall strategy. The outputs required of each laboratory should be defined and then ensured through accredited quality assurance. The political and scientific environment in which laboratories operate changes continuously, not only through evolving national and regional animal health priorities but also through new test technologies and enhancements to existing technologies. Active networks help individual laboratories to monitor, evaluate, and respond to such challenges and opportunities. The end result is enhanced emerging infectious disease preparedness across the region. 相似文献
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Joseph R. Morrissy 《CMAJ》1982,126(5):483-484
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Chen Cao Jingni He Lauren Mak Deshan Perera Devin Kwok Jia Wang Minghao Li Tobias Mourier Stefan Gavriliuc Matthew Greenberg A Sorana Morrissy Laura K Sycuro Guang Yang Daniel C Jeffares Quan Long 《Molecular biology and evolution》2021,38(6):2660
DNA sequencing technologies provide unprecedented opportunities to analyze within-host evolution of microorganism populations. Often, within-host populations are analyzed via pooled sequencing of the population, which contains multiple individuals or “haplotypes.” However, current next-generation sequencing instruments, in conjunction with single-molecule barcoded linked-reads, cannot distinguish long haplotypes directly. Computational reconstruction of haplotypes from pooled sequencing has been attempted in virology, bacterial genomics, metagenomics, and human genetics, using algorithms based on either cross-host genetic sharing or within-host genomic reads. Here, we describe PoolHapX, a flexible computational approach that integrates information from both genetic sharing and genomic sequencing. We demonstrated that PoolHapX outperforms state-of-the-art tools tailored to specific organismal systems, and is robust to within-host evolution. Importantly, together with barcoded linked-reads, PoolHapX can infer whole-chromosome-scale haplotypes from 50 pools each containing 12 different haplotypes. By analyzing real data, we uncovered dynamic variations in the evolutionary processes of within-patient HIV populations previously unobserved in single position-based analysis. 相似文献
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Mass-cultured algal biomass has been tested as a food source for a number of aquaculture animals because of its low cost and convenience. This paper reviews the results of nutritional studies on processed microalgae with respect to mollusc, crustacean, rotifer and fish culture. Research using species of Spirulina, Chlorella, Scenedesmus and other mass-produced algae indicates that microalgae can be an effective dietary component provided that processing, diet formulation and presentation requirements are met. Processed microalgae can be used to correct specific dietary deficiencies in artificial diets. Our research found that the growth and pigmentation of marron, Cherax tenuimanus (Decapoda, Crustacea), can be significantly enhanced by the incorporation of Dunaliella salina in its artificial diet. Likewise, rainbow trout, Oncorhynchus mykiss, were pigmented by Haematococcus pluvialis. 相似文献
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Irina Vyazunova Vilena I. Maklakova Samuel Berman Ishani De Megan D. Steffen Won Hong Hayley Lincoln A. Sorana Morrissy Michael D. Taylor Keiko Akagi Cameron W. Brennan Fausto J. Rodriguez Lara S. Collier 《PloS one》2014,9(11)
Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to gliomagenesis with low penetrance. Here we report the characterization of mice in which transposons are mobilized in the Glial Fibrillary Acidic Protein (GFAP) compartment. Glioma formation in these mice did not occur on an otherwise wild-type genetic background, but rare gliomas were observed when mobilization occurred in a p19Arf heterozygous background. Through cloning insertions from additional gliomas generated by transposon mobilization in the Rosa26 compartment, several candidate glioma genes were identified. Comparisons to genetic, epigenetic and mRNA expression data from human gliomas implicates several of these genes as tumor suppressor genes and oncogenes in human glioblastoma. 相似文献