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Mourad Hadj Slimen Hammadi Fakhfakh Mohamed Gassara Sofiane Kechaou Ali Bahloul Mohamed Nabil Mhiri 《Andrologie》2008,18(4):264-273
Introduction
Priapism is a prolonged, painful and persistent erection, unrelated to sexual stimulation. The management of priapism is complex and requires various medical or surgical treatments. The authors review the aetiology, treatment and outcome of priapism.Material and methods
26 cases of low-flow priapism were collected over a period of 23 years (1985–2007), corresponding to 22 adults and 4 children (average age: 32 years) with various types of priapism. The time to appropriate management after onset of priapism varied according to the aetiology and the time to consultation (range: 16 hours to 15 days).Results
Complete and persistent detumescence for the first 24 hours was obtained in 84% of cases, sometimes with multiple successive procedures. No case of early recurrence was observed. 21 patients were regularly followed for a period of 3 months to 10 years (mean follow-up: 2 years). There were 9 (42.9%) successes (recovery of normal erectile function), 4 partial results (19%) and 9 (30.1%) failures (complete erectile dysfunction).Conclusion
Low-flow priapism must be considered to be a serious andrological emergency. Medical treatment can be effective in early forms, but surgery must not be delayed to prevent permanent erectile dysfunction secondary to extensive corpora cavernosa fibrosis. 相似文献2.
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L’apport de l’imagerie hybride TEMP/TDM dans la prise en charge du cancer différencié de la thyroïde
A. Mhiri I. Slim M. Ghezaiel I. Meddeb I. El Bez I. Yeddes S. Gritli M.F. Ben Slimène 《Médecine Nucléaire》2012,36(10):554-560
IntroductionSingle photon emission computed tomography combined with a low dose computed tomography (SPECT/CT), is a hybrid imaging integrating functional and anatomical data. The purpose of our study was to evaluate the contribution of the SPECT/CT over traditional planar imaging of patients with differentiated thyroid carcinoma (DTC).MethodsPost-therapy iodine 131 (131I) whole-body scan followed by cervico-thoracic SPECT/CT, were performed in 100 patients with DTC.ResultsAmong these 100 patients followed for a predominantly papillary DTC, planar imaging and SPECT/CT, were perfectly concordant in 70% of patients and discordant in the remaining 30%. The use of fusion imaging SPECT/CT compared to conventional planar imaging allowed us to correct our therapeutic approach in 27% (27/100 patients), according to the protocols of therapeutic management of our institute.ConclusionSPECT/CT is a hybrid imaging modality which provides better identification and more correct anatomic localization of the foci of radioiodine uptake with impact on therapeutic management. 相似文献
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Zerjal T Rousselet A Mhiri C Combes V Madur D Grandbastien MA Charcosset A Tenaillon MI 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》2012,124(8):1521-1537
Transposable elements are the major component of the maize genome and presumably highly polymorphic yet they have not been
used in population genetics and association analyses. Using the Transposon Display method, we isolated and converted into
PCR-based markers 33 Miniature Inverted Repeat Transposable Elements (MITE) polymorphic insertions. These polymorphisms were
genotyped on a population-based sample of 26 American landraces for a total of 322 plants. Genetic diversity was high and
partitioned within and among landraces. The genetic groups identified using Bayesian clustering were in agreement with published
data based on SNPs and SSRs, indicating that MITE polymorphisms reflect maize genetic history. To explore the contribution
of MITEs to phenotypic variation, we undertook an association mapping approach in a panel of 367 maize lines phenotyped for
26 traits. We found a highly significant association between the marker ZmV1-9, on chromosome 1, and male flowering time. The variance explained by this association is consistent with a flowering delay
of +123 degree-days. This MITE insertion is located at only 289 nucleotides from the 3′ end of a Cytochrome P450-like gene,
a region that was never identified in previous association mapping or QTL surveys. Interestingly, we found (i) a non-synonymous
mutation located in the exon 2 of the gene in strong linkage disequilibrium with the MITE polymorphism, and (ii) a perfect
sequence homology between the MITE sequence and a maize siRNA that could therefore potentially interfere with the expression
of the Cytochrome P450-like gene. Those two observations among others offer exciting perspectives to validate functionally
the role of this region on phenotypic variation. 相似文献
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Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome 下载免费PDF全文
Hanein S Martin E Boukhris A Byrne P Goizet C Hamri A Benomar A Lossos A Denora P Fernandez J Elleuch N Forlani S Durr A Feki I Hutchinson M Santorelli FM Mhiri C Brice A Stevanin G 《American journal of human genetics》2008,82(4):992-1002
Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Both "uncomplicated" and "complicated" forms have been described with various modes of inheritance. Sixteen loci for autosomal-recessive "complicated" HSP have been mapped. The SPG15 locus was first reported to account for a rare form of spastic paraplegia variably associated with mental impairment, pigmented maculopathy, dysarthria, cerebellar signs, and distal amyotrophy, sometimes designated as Kjellin syndrome. Here, we report the refinement of SPG15 to a 2.64 Mb genetic interval on chromosome 14q23.3-q24.2 and the identification of ZFYVE26, which encodes a zinc-finger protein with a FYVE domain that we named spastizin, as the cause of SPG15. Six different truncating mutations were found to segregate with the disease in eight families with a phenotype that included variable clinical features of Kjellin syndrome. ZFYVE26 mRNA was widely distributed in human tissues, as well as in rat embryos, suggesting a possible role of this gene during embryonic development. In the adult rodent brain, its expression profile closely resembled that of SPG11, another gene responsible for complicated HSP. In cultured cells, spastizin colocalized partially with markers of endoplasmic reticulum and endosomes, suggesting a role in intracellular trafficking. 相似文献
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Manel Ben Abdallah Fatma Karray Najla Mhiri Nan Mei Marianne Quéméneur Jean-Luc Cayol Gaël Erauso Jean-Luc Tholozan Didier Alazard Sami Sayadi 《Extremophiles : life under extreme conditions》2016,20(2):125-138
Prokaryotic diversity was investigated in a Tunisian salt lake, Chott El Jerid, by quantitative real-time PCR, denaturing gradient gel electrophoresis (DGGE) fingerprinting methods targeting the 16S rRNA gene and culture-dependent methods. Two different samples S1-10 and S2-10 were taken from under the salt crust of Chott El Jerid in the dry season. DGGE analysis revealed that bacterial sequences were related to Firmicutes, Proteobacteria, unclassified bacteria, and Deinococcus-Thermus phyla. Anaerobic fermentative and sulfate-reducing bacteria were also detected in this ecosystem. Within the domain archaea, all sequences were affiliated to Euryarchaeota phylum. Quantitative real-time PCR showed that 16S rRNA gene copy numbers of bacteria was 5 × 106 DNA copies g?1 whereas archaea varied between 5 × 105 and 106 DNA copies g?1 in these samples. Eight anaerobic halophilic fermentative bacterial strains were isolated and affiliated with the species Halanaerobium alcaliphilum, Halanaerobium saccharolyticum, and Sporohalobacter salinus. These data showed an abundant and diverse microbial community detected in the hypersaline thalassohaline environment of Chott El Jerid. 相似文献
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L. Ammar-Keskes N. Chakroun-Fki F. Bouzid A. Bahloul S. Masmoudi M. Trifa T. Rebaï S. Rekik N. Mhiri 《Andrologie》1999,9(4):472-480
There are numerous controverses concerning the relationship between the presence of leukocytes in semen and male infertility. In the aim to determine the impact of pyospermia on sperm quality, we have realised a retrospective study in which we analysed and compared semen parameters and abnormalities frequencies between pyospermic and non pyospermic infertile patients. 833 spermiograms were included in this study. They were done in accord with WHO method. Leucocytes identification was performed by cyto-enzymologic method that reveals myelo-peroxydase in polymorphonuclear granulations. Pyospermia was considered when number of leucocytes was more than one million per millititre of sperm. The non pyospermic group was composed by sperm with leucocytospermia less than 50.000 per millilitre. The prevalence of pyospermia was 5.88%. There was not significative difference of semen parameters (volume, motility, morphology, number of spermatozoa and viability) between pyospermic and non pyospermic groups. In the other hand, no correlation was found between leucospermia and semen parameters. However, oligospermia was significantly more frequent in pyospermic group (40.8%) than in non pyospermic group (20,3%). Inversly, the frequence of teratospermia was significantly higher in non pyospermic group (47.2% vs 34.1%, p<0,05). These results suggest that inflammation and/or infection associated with pyospermia is complicated by reduction of spermatic ducts permeability. Although, the leucocytes would act in removing amorphous gametes by phagocytosis. No relationship was established between pyospermia and infection. In future, a prospective study would be done with exhaustive exploration of pyospermia etiology, with hopes to clarify the true link with infection and autoimmune reaction and to determine the effect of pyospermia on glandular activities in male genital tract and on functional properties of spermatozoa. 相似文献
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Petit M Lim KY Julio E Poncet C Dorlhac de Borne F Kovarik A Leitch AR Grandbastien MA Mhiri C 《Molecular genetics and genomics : MGG》2007,278(1):1-15
LTR-retrotransposons contribute substantially to the structural diversity of plant genomes. Recent models of genome evolution
suggest that retrotransposon amplification is offset by removal of retrotransposon sequences, leading to a turnover of retrotransposon
populations. While bursts of amplification have been documented, it is not known whether removal of retrotransposon sequences
occurs continuously, or is triggered by specific stimuli over short evolutionary periods. In this work, we have characterized
the evolutionary dynamics of four populations of copia-type retrotransposons in allotetraploid tobacco (Nicotiana tabacum) and its two diploid progenitors Nicotiana sylvestris and Nicotiana tomentosiformis. We have used SSAP (Sequence-Specific Amplification Polymorphism) to evaluate the contribution retrotransposons have made
to the diversity of tobacco and its diploid progenitor species, to quantify the contribution each diploid progenitor has made
to tobacco's retrotransposon populations, and to estimate losses or amplifications of retrotransposon sequences subsequent
to tobacco's formation. Our results show that the tobacco genome derives from a turnover of retrotransposon sequences with
removals concomitant with new insertions. We have detected unique behaviour specific to each retrotransposon population, with
differences likely reflecting distinct evolutionary histories and activities of particular elements. Our results indicate
that the retrotransposon content of a given plant species is strongly influenced by the host evolutionary history, with periods
of rapid turnover of retrotransposon sequences stimulated by allopolyploidy. 相似文献