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1.
Mehrabi Fatemeh Shamspur Tayebeh Sheibani Hassan Mostafavi Ali Mohamadi Maryam Hakimi Hamid Bahramabadi Reza Salari Elham 《Biometals》2021,34(6):1237-1246
BioMetals - Trimethoprim and sulfamethoxazole are prescribed for a broad spectrum of bacteria. However, the use of these medicines is restricted due to the risk of microbial resistance in the body.... 相似文献
2.
Azadeh Rezaei Mehdi Mahmoodi Fatemeh Mohammadizadeh Maryam Mohamadi Mohammad Reza Hajizadeh Mohammad Reza Mirzaei Soudeh Khanamani Falahati-pour 《Journal of cellular biochemistry》2019,120(8):12280-12289
Recent advances have put fundamental focus on the application of copper (II) (Cu [II]) complexes as agents for fighting against cancer. To determine whether [Cu(L)(2imi)] complex as a novel Cu complex can induce apoptosis in HepG2 as cancerous cells and L929 as normal cells via extrinsic or intrinsic apoptotic pathways, both cell lines were treated for 24 and 48 hours at IC50 concentrations of [Cu(L)(2imi)] complex. Then, the expression of some apoptosis-related genes including p53, caspase-8, bcl-2, and bax were assayed by real-time polymerase chain reaction. The [Cu(L)(2imi)] complex seems to inhibit the expression of bcl-2 in complex-treated HepG2 cancerous cells following the 24- and 48-hour treatment. The complex upregulated the p53, bax, and caspase-8 genes, therefore treatment of HepG2 cancerous cells with [Cu(L)(2imi)] complex induces programmed cell death via the upregulation of relative bax/bcl-2 ratio. Finally, this copper complex triggered apoptosis in HepG2 cells via both intrinsic and extrinsic pathway, whereas treatment of normal L929 cells with this complex induce apoptosis only via intrinsic pathway with the upregulation of relative bax/bcl-2 ratio and does not affect the expression level of caspase-8 gene and does not trigger the extrinsic pathway. Finally, these results obtained from present study confirm the role of a novel Cu complex on the induction of apoptosis process in HepG2 and L929 cells by overexpression of bax, inhibition of bcl-2 and increase of the relative bax/bcl-2 ratio. These results support that the [Cu(L)(2imi)] complex is able to induce apoptosis in cancerous cells, therefore, it has a potential for development as a novel anticancer drug. 相似文献
3.
Improved white spruce (Picea glauca) genome assemblies and annotation of large gene families of conifer terpenoid and phenolic defense metabolism
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René L. Warren Christopher I. Keeling Macaire Man Saint Yuen Anthony Raymond Greg A. Taylor Benjamin P. Vandervalk Hamid Mohamadi Daniel Paulino Readman Chiu Shaun D. Jackman Gordon Robertson Chen Yang Brian Boyle Margarete Hoffmann Detlef Weigel David R. Nelson Carol Ritland Nathalie Isabel Barry Jaquish Alvin Yanchuk Jean Bousquet Steven J. M. Jones John MacKay Inanc Birol Joerg Bohlmann 《The Plant journal : for cell and molecular biology》2015,83(2):189-212
4.
Razmjou J Mohamadi P Golizadeh A Hasanpour M Naseri B 《Journal of economic entomology》2012,105(2):592-597
Bird cherry-oat aphid, Rhopalosiphum padi (L.), a polyphagous species with a nearly worldwide distribution, is an important pest of wheat as well as the main vector of barley yellow dwarf virus. We evaluated the resistance categories of eight wheat lines including antibiosis, antixenosis, and tolerance against R. padi under laboratory conditions. The wheat lines tested were ERWYT 88-8, ERWYT 87-6, and ERWYT 87-4 (resistant); ERWYT 87-1, ERWYT 87-20, and ERWYT 88-11 (susceptible); ERWYT 88-12 and ERWYT 88-13 (intermediate). In the antibiosis experiment, R. padi produced fewest progeny on ERWYT 88-8, ERWYT 87-6, and ERWYT 87-4 in reproduction period. In the antixenosis test, R. padi performed best on ERWYT 87-1, ERWYT 87-20, and ERWYT 88-11. Fewer apterous aphids selected ERWYT 88-8, ERWYT 87-4, and ERWYT 87-6 lines indicating antixenosis of these lines to R. padi. In tolerance experiments, however growth parameters differed between treated and untreated seedlings of wheat lines with 10 aphids per day infestation during 21-d period, but not among eight wheat lines. The plant resistance index values were greatest for ERWYT 88-8 (9.71), followed by ERWYT 87-4 (7.04) and ERWYT 87-6 (4.76). ERWYT 88-8, ERWYT 87-6, and ERWYT 87-4 may be important sources of R. padi resistance for small grain breeding and integrated pest management programs. 相似文献
5.
Bao H Vepakomma M Sarkar MA 《The Journal of steroid biochemistry and molecular biology》2002,81(1):37-45
Estrogen is a major risk factor for endometrial cancer and it has been well-established that smokers have a significantly reduced risk of endometrial cancer. Localized levels of estrogen within the uterus may determine the estrogenic response. The objective of this research was to investigate effects of cigarette smoke related hydrocarbons (benzo(a)pyrene, BP) on uterine CYP1A1/2 and 1B1, enzymes involved in estrogen metabolism. Human endometrium epithelial cells (RL95-2) were incubated with various concentrations (0.05, 0.1, 0.5, 1, and 10mM) of BP for 48h. CYP1 catalytic activity, protein and mRNA levels were determined. Selective chemical and immuno-inhibitors were used to determine the contribution of individual CYP1 isoenzymes. Cells expressing CYP1A1, CYP1A2 and CYP1B1 were used for comparisons. CYP1A1/2 protein and mRNA levels were significantly elevated by BP. Low level of constitutive CYP1 activity was observed in RL95-2 cells, which was significantly induced by BP exposure (12-fold at 1mM). CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM). These studies suggest that CYP1A2 and CYP1B1 are not induced by BP in the endometrial cells. It also appears that CYP1A1 is one of the major CYP450 enzymes induced by BP. 相似文献
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7.
Karimi A. Rahmani F. Pirbalouti A. Ghasemi Mohamadi M. 《Russian Journal of Plant Physiology》2020,67(5):933-944
Russian Journal of Plant Physiology - Sage (Salvia officinalis L.) belonging to the Lamiaceae family, as the main herb in the world is cultivated in many countries for extraction of essential oil... 相似文献
8.
Plasmonics - In this paper, we propose new detectivity enhanced infrared detectors in which metamaterial cells are used to harvest the IR energy. Analytical models are developed and numerically... 相似文献
9.
Jasem Mohamadi Mahsa Motaghi Jafar panahi Mohamad Reza Havasian Ali Delpisheh Mitra Azizian Iraj Pakzad 《Bioinformation》2014,10(11):667-670
The purpose of the present study is to evaluate the sensitivity of Candida species isolated from oral candidiasis and diaper
dermatitis infections in children. The children referring to private and public clinics in Ilam, Iran were exmined for oral candidiasis
and diaper dermatitis. In this study, 248 oral candidiasis and diaper dermatitis samples were collected and cultured.Candida
species were identified by using standard methods. Resistance and sensitivity to amphotericin B, nystatin, ketoconazole,
fluconazole, itraconazole, clotrimazole, and posaconazole were determined using the CLSI M44-A standard disk diffusion method.
From the 248 studied samples, 149 were positive for Candida, among which the Candida albicans was the most prevalent (64.4%).
The resistance of different Candida species to nystatin, itraconazole, fluconazole, ketoconazole, clotrimazole, voriconazole, and
posaconazole were 4, 43, 34.2, 34.9, 21.5, 6, and 6.7%, respectively. No resistance to amphotericin B was observed. Considering
rather low resistance to nystatin, this drug is the best choice for oral candidiasis and diaper dermatitis. 相似文献
10.
A. Lohrasebi S. Mohamadi S. Fadaie H. Rafii-Tabar 《Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)》2012,28(3):221-229
We model the dynamics of the F0 component of the F0F1-ATPase mitochondrion-based nano-motor operating in a stochastically-fluctuating medium that represents the intracellular environment. The stochastic dynamics are modeled via Langevin equation of motion wherein fluctuations are treated as white noise. We have investigated the influence of an applied alternating electric field on the rotary motion of the F0 rotor in such an environment. The exposure to the field induces a temperature rise in the mitochondrion’s membrane, within which the F0 is embedded. The external field also induces an electric potential that promotes a change in the mitochondrion’s transmembrane potential (TMP). Both the induced temperature and the change in TMP contribute to a change in the dynamics of the F0. We have found that for external fields in the radio frequency (RF) range, normally present in the environment and encountered by biological systems, the contribution of the induced thermal effects, relative to that of the induced TMP, to the dynamics of the F0 is more significant. The changes in the dynamics of the F0 part affect the frequency of the rotary motion of the F0F1-ATPase protein motor which, in turn, affects the production rate of the ATP molecules. 相似文献