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Moayad M Aljarabah Neil R Borley James MD Wheeler 《International Seminars in Surgical Oncology : ISSO》2007,4(1):20
Background
appendiceal tumours are rare, they may be encountered unexpectedly in any acute or elective abdominal operation, many of these tumours are not appreciated intraoperatively and are diagnosed only during formal histopathological analysis of an appendicectomy specimen. Herein we present a case of appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, we also review the literature of unusual presentations of appendiceal tumours.Case Presentation
we report a case of left sided large bowel obstruction found to be secondary to an appendiceal adenocarcinoma. The patient presented with abdominal pain, distension and constipation, CT scan showed large bowel obstruction thought to be due to a sigmoid tumour, on laparotomy the appendix was also noted to be abnormal. A low Hartman's was performed with en-bloc total hysterectomy and bilateral salpigo-oophorectomy. A separate ileocaecal resection with end ileostomy was also performed, pathology specimens showed that the primary neoplasm was the appendix with metastasis to the distal sigmoid.Conclusion
appendiceal tumours are rare, they usually present as acute appendicitis, other presentations are far less common.2.
Naif Mohammed Al-Hada Elias B. Saion Abdul Halim Shaari Mazliana A. Kamarudin Moayad Husein Flaifel Sahrim Hj Ahmad Salahudeen A. Gene 《PloS one》2014,9(8)
A facile thermal-treatment route was successfully used to synthesize ZnO nanosheets. Morphological, structural, and optical properties of obtained nanoparticles at different calcination temperatures were studied using various techniques. The FTIR, XRD, EDX, SEM and TEM images confirmed the formation of ZnO nanosheets through calcination in the temperature between 500 to 650°C. The SEM images showed a morphological structure of ZnO nanosheets, which inclined to crumble at higher calcination temperatures. The XRD and FTIR spectra revealed that the samples were amorphous at 30°C but transformed into a crystalline structure during calcination process. The average particle size and degree of crystallinity increased with increasing calcination temperature. The estimated average particle sizes from TEM images were about 23 and 38 nm for the lowest and highest calcination temperature i.e. 500 and 650°C, respectively. The optical properties were determined by UV–Vis reflection spectrophotometer and showed a decrease in the band gap with increasing calcination temperature. 相似文献
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Fatemeh Safa Shams Abyaneh Moayad Hossaini Sadr Adeleh Divsalar 《Journal of biomolecular structure & dynamics》2018,36(4):893-905
Investigation of side effects and solubility of anticancer drugs is a major challenge in chemotherapy science. Thus, design and synthesis of cisplatin analogs with higher lipophilicity as novel water-soluble anticancer drugs is valuable. In this work, two new Pt(II) complexes were synthesized with formula cis-[Pt(NH3)2(amylgly)]NO3 and cis-[Pt(amylamine)2(amylgly)]NO3, where gly is penthyl glycine as an amino acid. The new compounds were synthesized and extensively characterized using analytical techniques; spectroscopic methods, and conductivity measurement. The anticancer activity of synthesized complexes was investigated against colon cancer cell line HCT116 using MTT assay and results showed excellent anticancer activity with Cc50 values of 36 and 270 M after 24-h incubation time for cis-[Pt(NH3)2(amylgly)]NO3 and cis-[Pt(NH2-amyl)2(amylgly)]NO3, respectively; which is lower than that for cisplatin. These complexes were also interacted with highly polymerized calf thymus DNA and the binding mode of the complexes to CT-DNA was evaluated by fluorescence, circular dichroism, and UV spectroscopy. The calculation of binding and thermodynamic of Pt(II) complexes with CT-DNA can provide deeper insight into mechanism of the action of these types of complexes with nucleic acids. So, thermodynamic parameters were also determined according to isothermal titration. In comparison with cis-[Pt(NH3)2(amylgly)]NO3 in DNA interaction, the result show that cis-[Pt(NH2-amyl)2(amylgly)]NO3 has higher affinity with binding constant Kf = 8.72 mM to CT-DNA. The results indicate that cis-[Pt(amylamine)2(amylgly)]NO3 with large and bulky aliphatic group bind to CT-DNA by different modes and covalent and groove bindings were preferred mode of interaction with DNA. 相似文献
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Dana AlAli Abdallah Elshafeey Malik Mushannen Hussam Kawas Ameena Shafiq Narjis Mhaimeed Omar Mhaimeed Nada Mhaimeed Rached Zeghlache Mohammad Salameh Pradipta Paul Moayad Homssi Ibrahim Mohammed Adeeb Narangoli Lina Yagan Bushra Khanjar Saad Laws Mohamed B. Elshazly Dalia Zakaria 《Journal of cellular and molecular medicine》2022,26(3):636
Since COVID‐19 took a strong hold around the globe causing considerable morbidity and mortality, a lot of effort was dedicated to manufacturing effective vaccines against SARS‐CoV‐2. Many questions have since been raised surrounding the safety of the vaccines, and a lot of media attention to certain side effects. This caused a state of vaccine hesitancy that may prove problematic in the global effort to control the virus. This review was undertaken with the aim of putting together all the reported cardiovascular and haematological events post COVID‐19 vaccination in published literature and to suggest possible mechanisms to explain these rare phenomena. 相似文献
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Jin Tong Ballel. Z. Moayad Yun-hai Ma Ji-yu Sun Dong-hui Chen Hong-lei Jia Lu-quan Ren 《仿生工程学报(英文版)》2009,6(3):280-289
The effects of biomimetic designs of tine furrow opener surface on equivalent pressure and pressure in the direction ofmotion on opener surface against soil were studied by finite element method (FEM) simulation and the effects of these designson tool force and power requirements were examined experimentally.Geometrical structures of the cuticle surfaces of dungbeetle (Copris ochus Motschulsky) were examined by stereoscopy.The structures of the cuticle surfaces and Ultra High Mo-lecular Weight Polyethylene (UHMWPE) material were modeled on surface of tine furrow opener as biomimetic designs.Sevenfurrow openers were analyzed in ANSYS program (a FEM simulation software).The biomimetic furrow opener surfaces withUHMWPE structures were found to have lower equivalent pressure and pressure in the direction of motion as compared to theconventional surface and to the biomimetic surfaces with textured steel-35 structures.It was found that the tool force and powerwere increased with the cutting depth and operating speed and the biomimetic furrow opener with UHMWPE tubular sectionridges showed the lowest resistance and power requirement against soil.. 相似文献
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Maryam Arabi Yousef Al-Najjar Nada Mhaimeed Mohammad A. Salameh Pradipta Paul Jamal AlAnni Ali A. Abdelati Ibrahim Laswi Bushra Khanjar Dana Al-Ali Abdallah Elshafeey Omar Mhaimeed Zain Burney Ashton D'Souza Pratyaksha Sinha Mohammad Bhatti Krishnadev V. Pillai Moayad Homssi Khalifa Bshesh Lina Yagan Dalia Zakaria 《Journal of cellular and molecular medicine》2023,27(11):1443-1464
The Omicron variant was first detected in October 2021, which evolved from the original SARS-CoV-2 strain and was found to possess many mutations. Immune evasion was one of the notable consequences of these mutations. Despite Omicron exhibiting increased transmissibility, the rates of hospitalizations and deaths among patients infected with this variant were substantially lower when compared to other strains. However, concluding that the Omicron variant is less severe than other variants of SARS-CoV-2 requires consideration of multiple factors, including the vaccination status of infected patients as well as any previous infections with other variants. This review compiled data about any reported indicators of severity in Omicron-infected patients, including studies comparing Omicron with other variants while adjusting for confounders. A comprehensive search was conducted using different databases to target any studies about Omicron. In total, 62 studies met our inclusion criteria and were included in this study. Many studies reported a significantly reduced risk of hospitalization, ICU admission, need for oxygenation/ventilation, and death in Omicron-infected patients compared to patients infected with other variants, such as Delta. Some studies, however, reported comparable severity in Omicron infected patients as to other variants emphasizing a substantial risk for severe illness. Furthermore, the COVID-19 vaccines were less effective against Omicron relative to previous lineages, except after receiving the booster dose. One study recommended vaccination during pregnancy, which may help prevent future cases of severe SARS-CoV-2 pneumonia in neonates and young infants due to the transfer of humoral response from the mother. 相似文献
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