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C Crone J Frokjaer-Jensen JJ Friedman O Christensen 《The Journal of general physiology》1978,71(2):195-220
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Kotwica J Skarzynski D Mlynarczuk J Rekawiecki R 《Prostaglandins & other lipid mediators》2003,70(3-4):351-359
The role of prostaglandin E2 (PGE2) in basal and noradrenaline (NA)-stimulated utilization of high density lipoprotein (HDL) as a source of cholesterol for progesterone synthesis was examined. In Experiment 1, a cannula was inserted into the aorta abdominalis through the coccygeal artery (cranial to the origin of the ovarian artery) in mature heifers, to facilitate infusion of NA (4 mg/30 min; n = 3) on day 10 of the estrous cycle. Three other heifers were similarly cannulated to serve as control. Before, during, and after NA or saline infusion, blood samples from the vena cava were collected every 5-15 min for analysis of PGE2, progesterone, and cholesterol. Each NA infusion stimulated (P < 0.01) secretion of both hormones in heifers. Short-duration increases (P < 0.05) in progesterone were observed due to the infusion of NA while cholesterol was not altered significantly. In addition, increases in PGE2 concentrations (P < 0.05) compared to controls were seen after NA infusion. Therefore, we used an in vitro model to verify the effect of PGE2 on HDL utilization by luteal cells from day 5 to 10 of the estrous cycle. In the preliminary experiment, 10(-6) M of PGE2 out of four different doses examined was selected for further studies, since it evoked the highest release of progesterone. In the next experiment, it was found that HDL increases progesterone secretion by luteal cells and both PGE2 and LH increased (P < 0.05) the response to HDL while NA did not. In the last in vitro experiment, progesterone stimulated PGE2 secretion by luteal cells. In conclusion, PGE2 may be directly involved in the utilization of cholesterol from HDL for progesterone synthesis. Furthermore, PGE2 may influence NA-stimulated progesterone secretion by the corpus luteum (CL). It is concluded that there is a positive feedback loop between progesterone and luteal PGE2 during days 5-10 of the estrous cycle. 相似文献
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Progesterone (P4) was found to interfere directly with the interaction of oxytocin (OT) with its own receptor in bovine endometrium. The aim of these studies was to investigate whether other steroids have a similar effect. Endometrial slices and epithelial endometrial cells from days 14 to 18 of the estrous cycle were used. Progesterone (P4), pregnenolone (P5), 17beta-hydroxyprogesterone (17-OHP4), the P4 receptor antagonist (aP4), and testosterone (T4) did not affect (P > 0.01) basal secretion of PGE2 and PGF 2alpha during 4h of incubation but all steroids inhibited (P < 0.05) OT-stimulated PGF2alpha secretion both from endometrial slices and from dispersed cells. None of the steroids used affected OT-stimulated PGE2 secretion from the cells (P > 0.01). In the next experiment it was studied whether P5, 17-OHP4 and P4 pretreatment for 30min modifies intracellular mobilization of Ca(2+) in response to OT. Oxytocin induced a rapid increase in intracellular Ca(2+)concentrations within 15s, while cells pretreated with steroids this increase occurred later. The total amount of intracellular Ca(2+)concentrations was lower (P < 0.05) in cells preincubated with steroids compared to controls. We conclude that steroids and aP4 are able to suppress OT-stimulated endometrial PGE2 and PGF2alpha secretion via a non-genomic pathway. 相似文献
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Lipoteichoic acid is an important microbe-associated molecular pattern of Lactobacillus rhamnosus GG
Claes Ingmar JJ Segers Marijke E Verhoeven Tine LA Dusselier Michiel Sels Bert F De Keersmaecker Sigrid CJ Vanderleyden Jos Lebeer Sarah 《Microbial cell factories》2012,11(1):1-8