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1.
M P Ivanova V Iu Mel'nikov 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1988,38(3):427-433
In summation and averaging of sections of the EEG of sensorimotor cortex of both cerebral hemispheres recorded during human static effort of definite duration, a complex of negative-positive oscillations was observed. These oscillations appear before the beginning of the effort, accompany its execution and finishing and are also recorded after cessation of muscles activity. Before the beginning, the potential of readiness is formed. The execution of the effort is accompanied by a slow negative wave which in some people may be broken by a pronounced positivity. Further a "final" potential appears; its fast positive oscillation is formed before the end of the effort, and a slow negative wave in which it turns, appears only after muscles relaxation. 相似文献
2.
Comparative assessment of the properties of a factor inhibiting macrophage migration and interferon]
O F Mel'nikov L D Krivokhatskaia Ia L Povolotski? 《Biulleten' eksperimental'no? biologii i meditsiny》1977,83(3):302-303
The authors investigated some functional properties of interferon and the macrophages migration inhibitory factor (MIF) obtained by stimulation of human tonsil lymphocytes with the virus of Newcastle disease (NDV) or O-streptolysin. Both the interferon and MIF inhibited actively the migration of human tonsil cells, but differed by the anti-viral activity, and sensitivity to heating at 56 degrees C for 30 min. Stimulation of human tonsil lymphocytes with NDV leads to production of a more wide range of delayed hypersensitivity mediators than stimulation with O-streptolysin. 相似文献
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Electron-microscopic and electron-cytochemical method were used to indicate the capability of Pseudomonas mallei (str. N 10230) to produce extracellular slime during the agent growth on the meat-peptone agar. In case of guinea pigs infection the agent forms a capsule that defends the pathogen from phagocytosis. 相似文献
6.
Effect of phytosterols and phytostanols on the solubilization of cholesterol by dietary mixed micelles: an in vitro study 总被引:4,自引:0,他引:4
Mel'nikov SM Seijen ten Hoorn JW Eijkelenboom AP 《Chemistry and physics of lipids》2004,127(2):121-141
The effect of a plant sterol, beta-sitosterol (SI), and a plant stanol, sitostanol (SS), on the solubilization of cholesterol (CH) by model dietary mixed micelles was examined under in vitro conditions with the use of gas chromatography, isothermal titration calorimetry, NMR spectroscopy and cryogenic transmission electron microscopy techniques. Free SI and SS were shown to reduce the concentration of CH in dietary mixed micelles via a dynamic competition mechanism. CH, SI and SS affect the microstructure of lipid vesicles and influence the process of amphiphilic self-assembly of nutrients in the gut with the formation of dietary mixed micelles in a similar manner. Therefore, substitution of CH by phytosterols and phytostanols in the diet does not lead to the notable changes in the mechanism of dietary mixed micelle formation and does not affect the process of the intestinal transport of nutrients and drugs via the micellar diffusion mechanism. Our experimental findings demonstrate that the introduction of plant sterols and plant stanols into the diet is clearly beneficial for the reduction of the intestinal uptake of cholesterol. Due to the limited capacity of dietary mixed micelles to embody hydrophobic sterol/stanol molecules, the micellar concentration of cholesterol is reduced and hence, its transport towards the intestinal brush border membrane decreases. 相似文献
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Pavlova LI Gorbunov MA Vorob'eva MS Karavanov AS Grachev VP Ladyshenskaia IP Rasshchepkina MN Mel'nikova LN Lebedeva TM Mel'nikov NA Gusmanova AG Deviatkov MIu Rozanova EV Mukachev MA 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1999,(6):50-53
The word deals with the results obtained in the study of the reactogenicity and immunological activity of concentrated and inactivated tissue-culture tick-borne encephalitis vaccine, manufactured by the Chumakov Institute of Poliomyelitis and Viral Encephalitides, in the immunization of children and adolescents. The vaccine proved to be moderately reactogenic and exhibited pronounced immunological activity. In 91.5% of the immunized children the fourfold increase of the antibody level was observed. On the basis of the data obtained in this study the tick-borne encephalitis vaccine was recommended for use in medical practice for the prophylaxis of tick-borne encephalitis among children and adolescents. 相似文献
8.
Mel'nikov VG Kombarova SIu Borisova OIu Volozhantsev NV Verevkin VV Volkovoĭ KI Mazurova IK 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2004,(1):3-7
Among 828 C. diphtheriae nontoxigenic cultures isolated in different region of Russia in 1994-2002, 114 cultures (13.8%) had the gene of diphtheria toxin (gene tox) and were thus called nontoxigenic tox-carrying (NTTC) strains. All NTTC strains were found to belong to biovar mitis and formed neither normal, nor "defective" diphtheria toxin. The most of NTTC strains (94%) belonged to ribotype "Moskva", not occurring among C. diphtheriae toxigenic strains. The incapacity of NNTC strains of forming diphtheria toxin was caused by mutation: the deletion of one nucleotide which led to the shift of the open reading frame and to the formation of the stop codon. The results of these studies are indicative of the fact that a sufficiently homogeneous and isolated group of C. diphtheriae nontoxigenic strains is spread in Russia. These strains carry the nonexpressing gene of diphtheria toxin and are of no epidemic importance in diphtheria infection. 相似文献
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The relationship between the rheological blood properties and several indices of age-related erythrocyte structure was established in endurance-training athletes (n = 21). Unlike nonathletic subjects, the athletes had a shift in the age-related structure towards younger erythrocyte forms: reticulocytosis, increased erythrocyte resistance, increased percentage of cells with a diameter exceeding 8 m, and decreased percentage of cells with a diameter of less than 7 m. The established correlations between total reticulocyte concentration, mature and immature reticulocyte concentrations, and percentage of cells with a diameter either exceeding 8 m or less than 7 m, on the one hand, and hemorheological parameters (blood viscosity, erythrocyte suspension viscosity, erythrocyte aggregation, and surface/volume ratio) and physical work capacity, on the other hand, revealed a significant effect of younger erythrocyte forms on hemorheological indices in athletes. 相似文献