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1.
Mycobacterium ulcerans Disease: Experience with Primary Oral Medical Therapy in an Australian Cohort
N. Deborah Friedman Eugene Athan Andrew J. Hughes Masoomeh Khajehnoori Anthony McDonald Peter Callan Richard Rahdon Daniel P. O'Brien 《PLoS neglected tropical diseases》2013,7(7)
Background
Mycobacterium ulcerans (MU) is responsible for disfiguring skin lesions and is endemic on the Bellarine peninsula of southeastern Australia. Antibiotics have been shown to be highly effective in sterilizing lesions and preventing disease recurrences when used alone or in combination with surgery. Our practice has evolved to using primarily oral medical therapy.Methods
From a prospective cohort of MU patients managed at Barwon Health, we describe those treated with primary medical therapy defined as treatment of a M. ulcerans lesion with antimicrobials either alone or in conjunction with limited surgical debridement.Results
From 1/10/2010 through 31/12/11, 43 patients were treated with exclusive medical therapy, of which 5 (12%) also underwent limited surgical debridement. The median patient age was 50.2 years, and 86% had WHO category 1 and 91% ulcerative lesions. Rifampicin was combined with ciprofloxacin in 30 (70%) and clarithromycin in 12 (28%) patients. The median duration of antibiotic therapy was 56 days, with 7 (16%) receiving less than 56 days. Medication side effects requiring cessation of one or more antibiotics occurred in 7 (16%) patients. Forty-two (98%) patients healed without recurrence within 12 months, and 1 patient (2%) experienced a relapse 4 months after completion of 8 weeks of antimicrobial therapy.Conclusion
Our experience demonstrates the efficacy and safety of primary oral medical management of MU infection with oral rifampicin-based regimens. Further research is required to determine the optimal and minimum durations of antibiotic therapy, and the most effective antibiotic dosages and formulations for young children. 相似文献2.
Heidar Zahra Hamzepour Negar Zadeh Modarres Shahrzad Mirzamoradi Masoomeh Aghadavod Esmat Pourhanifeh Mohammad Hossein Asemi Zatollah 《Biological trace element research》2020,193(2):319-325
Biological Trace Element Research - This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in... 相似文献
3.
Asghari Mohammad Shaghaghi Zahra Farzipour Soghra Ghasemi Arash Hosseinimehr Seyed Jalal 《Molecular biology reports》2019,46(6):5909-5917
Molecular Biology Reports - Olanzapine (OLA), is prescribed as an anti-psychotic medicine in schizophrenia patients. In this study, the protective effect of OLA against genotoxicity and... 相似文献
4.
Kourosh Bamdad Zahra Adel Masoomeh Esmaeili 《Journal of cellular biochemistry》2019,120(6):10572-10575
Exposure to electromagnetic fields is considered as a potential hazard for biological systems. The objective of our investigation is the study of probable consequences of radiofrequency electromagnetic fields from Wi-Fi router devices on the short-term memory, and attention's levels. A population consisting of 312 female college students (14 to 17 years old) was elected by cluster random sampling. Teenagers were divided into two groups of control group (Wi-Fi nonusers; n = 138), and experiment group (Wi-Fi users; n = 174). Both groups have been examined using short-term memory tests; selective attention, and also divided attention tests. According to the results, there was no significant difference between using Wi-Fi router devices on levels of selective attentions and short-term memory of the sample students with the control group. However, analyses revealed that there is a significant correlation between the use of Wi-Fi routers and declining levels of divided attentions. Our investigation has demonstrated the adverse consequences of 2.4-2.48 GHz radiofrequency electromagnetic fields of Wi-Fi router devices on divided attention levels of female university students that should be mentioned as a technological risk factor and taken into account by healthcare organizations. 相似文献
5.
The effects of interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) perfused locally into the anterior hypothalamus (AHY) on serotonin (5-hydroxytryptamine, 5-HT) release were investigated in the same region using in vivo microdialysis in conscious, freely moving F344 rats. IL-1beta (1 ng/rat) or IL-6 (50 ng/rat) injected directly into the AHY elicited a rapid and transient statistically significant increase in extracellular 5-HT levels (to 161% and 145% of the respective AUC (area under the curve) basal value, 100%). Intra-hypothalamic infusion of IL-1-receptor antagonist IL-1Ra (2 mug/rat) prevented this effect of IL-1beta, but not that of IL-6, suggesting an IL-1beta-independent mechanism for hypothalamic 5-HT release by this latter cytokine. Furthermore, intra-hypothalamic co-perfusion of IL-6 with IL-1beta at sub-optimal doses (10 ng/rat and 0.5 ng/rat, respectively) synergized in releasing hypothalamic 5-HT, thus providing in vivo evidence that both cytokines, IL-6 and IL-1beta are able to modulate the neuronal 5-HT response in the rat AHY. 相似文献
6.
Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus 总被引:1,自引:0,他引:1
Razzaghi-Abyaneh M Yoshinari T Shams-Ghahfarokhi M Rezaee MB Nagasawa H Sakuda S 《Bioscience, biotechnology, and biochemistry》2007,71(9):2329-2332
Dillapiol was isolated from the essential oil of dill as a specific inhibitor of aflatoxin G1 production. It inhibited aflatoxin G1 production by Aspergillus parasiticus with an IC50 value of 0.15 microM without inhibiting aflatoxin B1 production or fungal growth. Apiol and myristicin, congeners of dillapiol, showed similar activity with IC50 values of 0.24 and 3.5 microM, respectively. 相似文献
7.
Razzaghi-Abyaneh M Shams-Ghahfarokhi M Eslamifar A Schmidt OJ Gharebaghi R Karimian M Naseri A Sheikhi M 《Mycopathologia》2006,161(4):245-249
The effects of Akacid plus, a novel guanidine-based polymer first introduced as a biocidal and disinfectant agent were studied on Aspergillus parasiticus growth and its aflatoxin (AF) productivity. The fungus was cultured on yeast extract-sucrose (YES) broth in presence of various twofold serial dilutions of 25% Akacid plus (1.5-96 microL/50 mL medium) and then incubated in shaking condition with 150 rev./min at 28 degrees C for 96 h. Based on obtained results, Akacid plus was found to significantly inhibit both growth and aflatoxin B1 (AFB1) synthesis in very low concentrations in a dose-dependent manner. Fungal growth inhibition was determined in the range of 9.6-99.6% in mycelia exposed to the total concentration range of 1.5-48 microL. A final concentration of 96 microL was necessary to completely inhibit the growth of fungus. Under similar conditions, AFB1 synthesis was found to be strongly inhibited by 8.1-98.0% in presence of 1.5-24 microL Akacid plus with a maximum of 100% by 48 microL concentration. With respect to the unique physico-chemical properties of Akacid plus, its marked inhibitory effects on A. parasiticus growth and its AFB1 synthesis shown for the first time in this study make it a promising candidate for application in prevention programmes of AF contamination of susceptible crops. 相似文献
8.
9.
Gholamreza Hassanzadeh Samaneh Hosseini Quchani Mohammad Ali Sahraian Farid Abolhassani Mohammad Ali Sadighi Gilani Masoomeh Dehghan Tarzjani Fatemeh Atoof 《Cellular and molecular neurobiology》2016,36(6):865-872
Multiple sclerosis is a neurodegenerative disease characterized by the present of leukocytes in the brain tissue and subsequently the formation of sclerotic plaques. Leukocytes penetration into the blood–brain barrier is related to several factors, such as, the conversion of leukocyte gene expression or plasma characteristics. In this frame, we explore alteration of matrix metalloproteinase-2 (MMP-2), transforming growth factor beta (TGF-β) family, and Claudin-11 (as a main myelin structural protein) in leukocytes and blood plasma of multiple sclerosis patients compared to the normal group. Blood samples were collected from thirteen men affected by MS and fifteen healthy men. Leukocyte gene expression was measured using real-time PCR and plasma parameters were examined by ELISA. The results of this study showed that the gene expression of Claudin-11 was significantly higher in MS group compared with normal. Interestingly, the MMP-2 pattern was similar to Claudin-11 and correlated positively with it. It was observed that, although the expressions of TGF-β1 and TGF-β2 are down-regulated in the leukocytes of subjects with MS, they showed higher levels of these cytokines in blood plasma. The plasma level of TGF-β3 in MS patients was higher than normal and correlated with Claudin-11 concentration. In conclusion, the aberrant pattern of Claudin-11, TGF-βs family, and MMP-2 expression in leukocytes of the MS patients was observed in this study. Moreover, the plasma levels of TGF-βs family increased in the MS group. The findings of this study provide clues for further investigations to assay MS pathogenesis. 相似文献
10.
Masoomeh Etehadnia Doug R. Waterer Karen K. Tanino 《Journal of Plant Growth Regulation》2008,27(4):331-341
The phytohormone abscisic acid (ABA) has been proposed to act as a mediator in plant responses to a range of stresses, including
salt stress. Most studies of ABA response apply ABA as a single dose. This may not resemble the prolonged increasing endogenous
ABA levels that can occur in association with slowly increasing salinity stresses in nature or field situations. Salt stress
response based on method of ABA application was examined in four potato genotypes of varying salt stress resistance: the sensitive
ABA-deficient mutant and its normal sibling, a resistant genotype line 9506, and commercial cultivar ‘Norland’ of moderate
resistance. ABA was applied by root drench at 0, 50, 75, or 100 μM concentrations through a single dose, or by slowly increasing
multiple ABA doses in a sand-based growing system under greenhouse conditions. Salt tolerance was then evaluated after 2 weeks
of exposure to 150–180 mM NaCl stress. The method of ABA application had a marked effect on the responses to salt stress.
Plant responses to the method of ABA application were differentiated according to (1) growth rate, (2) root water content,
and (3) apparent shoot growth response. Under a single dose, growth rate increased in all genotypes under salt stress, whereas
slowly increasing multiple ABA applications generally maintained stable growth rates except in the ABA-deficient mutant where
there was an upward growth trend. Percent root water content was elevated only under slowly increasing multiple ABA doses
in two genotypes, whereas none of the single-dose treatments induced any change. The single ABA dose enhanced vertical growth,
whereas the slowly increasing multiple ABA dose applications enhanced lateral shoot growth. Because exogenous application
is still an artificial system, endogenous ABA was supplied through grafting of ABA-deficient mutant scions onto rootstocks
with known elevated ABA levels. Multiple exogenous ABA applications as low as 50 μM elicited similar shoot water content responses
as grafting treatments without ABA application in the mutant genotype but had no effect on the ABA normal sibling. Shoot dry
weight was significantly increased through grafting over all exogenous ABA treatments. Our study further indicates that the
method of ABA application regime in itself can alter plant responses under salt stress and that certain application regimes
may reflect responses to elevated endogenous levels of ABA. 相似文献