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1.
In various applications one faces the problem of estimating a signal from discontinuous observations. For example, in biomedical applications the signal may be the ‘state’ of a given organ and one observes through an external counter the amount of radioactivity sequestered by the organ after injection of a radioactive tracer. Here the problem is studied in the context of nonlinear filtering when the signal can be modelled as either a random variable or a diffusion process, and the observations have a continuous and a purely discontinuous component; both components may be affected by the signal. When the signal is a random variable an explicitly computable solution is obtained; for the diffusion case the solution is given as a sequence of approximating filters that can be computed recursively. 相似文献
2.
The metabolism of glucose 1-phosphate and glucose 6-phosphate and their influence on the metabolism of glucose in rat-diaphragm muscle 总被引:6,自引:4,他引:2 下载免费PDF全文
3.
Transfer factor in chronic mucocutaneous candidiasis 总被引:3,自引:0,他引:3
Fifteen patients suffering from chronic mucocutaneous candidiasis were treated with an in vitro produced TF specific for Candida
albicans antigens and/or with TF extracted from pooled buffy coats of blood donors. CMI of the patients was assessed using
the LMT and the LST in presence of candidine. The aim of the study was the clinical evaluation of TF treatment and the incidence
of positive tests before, during, and after therapy. Immunological data were matched using the Chi square test. 87 LMT were
performed for each antigen dose and at the dilution of 1/50, 58.9% (33/56) tests were positive during non-treatment or non-specific
TF treatment. On the contrary 83.9% (26/31) were positive during specific TF treatment (P<0.05). In the LST, a significant
decrease of thymidine uptake in the control cultures in presence of autologous or AB serum was observed when patients were
matched according to non-treatment, and both non specific (P<0.05) and specific TF treatment (P<0.01). Only during specific
TF treatment was a significant increase of reactivity against the Candida antigen at the highest concentration noticed, when
compared with the period of non specific treatment (P<0.01). Clinical observations were encouraging: all but one patient experienced
significant improvement during treatment with specific TF. These data confirm that orally administered specific TF, extracted
from induced lymphoblastoid cell-lines, increases the incidence of reactivity against Candida antigens in the LMT. LST reactivity
appeared not significantly increased with respect to the periods of non treatment, but was significantly increased when it
was compared to the non-specific TF treatment periods. At the same time, a clinical improvement was noticed. 相似文献
4.
G. Fiorelli F. Gori L. Masi U. Frediani M. L. Brandi A. Tanini P. A. Bernabei R. T. Ballock L. M. Wakefield M. B. Sporn 《Journal of cellular physiology》1994,160(3):482-490
Increasing evidence suggests that transforming growth factor-β (TGF-β) is involved in bone formation during remodeling. Using a recently cloned human leukemic cell line (FLG 29.1 cells) we demonstrate that these cells synthesize and secrete TGF-β1 and that exogenous or autocrine TGF-β1 can induce the same features of osteoclastic-like cells, exerting its effects through the binding to TGF-β specific receptors. Scatchard analysis of 125I-labeled TGF-β1 to FLG 29.1 cells revealed the presence of a single high affinity binding site with a Kd value of ~25 pM and a binding capacity of ~900 sites/cell. Affinity labeling experiments showed that FLG 29.1 cells express type I and type II TGF-β receptors. Stimulation of FLG 29.1 cells with low TGF-β1 doses reduced cell proliferation and increased cell adhesion and tartrate resistant acid phosphatase (TRAcP) activity. Pretreatment of FLG 29.1 cells with TGF-β1 caused a significant and dose-dependent response to calcitonin. Northern blot of total mRNA and analysis of the conditioned media (CM) showed that TGF-β1 was synthesized by FLG 29.1 cells. TPA treatment, which induces partial differentiation of these cells, markedly increased TGF-β1 mRNA expression and growth factor release. The majority of TGF-β1 secreted by TPA-treated cells was in its latent form. However, anti-TGF-β antibodies inhibited TGF-β1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-β1 and indicating that the cells can activate and respond to the TGF-β that they secrete. These findings support a potential autocrine role for TGF-β1 in osteoclast differentiation. © 1994 Wiley-Liss, Inc. 相似文献
5.
Sex differences in eicosanoid production in platelets and vessel walls have been studied in control and n-6 fatty acid supplemented rats. In platelet rich plasma (PRP) of control female rats, arachidonic acid (AA) levels in phospholipids (PL), thromboxane B2 (TxB2) formation following collagen stimulation and aggregatory responses to collagen were higher than in PRP of male rats. 6 keto PGF1α release from PRP-perfused isolated aortas were the same for both sexes, but the antiaggregatory activity of the wall was higher in males than in females, in association with a greater sensitivity of male platelets to prostacyclin.The administration of n-6 fatty acid supplements increased AA level in PL, TxB2 production and aggregation only in male platelets. Production of 6 keto PGF1α and the antiaggregatory activity of aortic walls were reduced after dietary treatment in males, but biochemical and functional parameters were not correlated in females.The results indicate complex sex-related differences in fatty acid metabolism and eicosanoid production, and in responses to n-6 dietary fatty acids in platelets and the vascular system in the rat. 相似文献
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In 2008, during a rescue excavation in the Sa Osa area, near the town of Cabras (Sardinia, Italy), a Nuragic settlement was discovered. The excavation revealed numerous pits, wells and structures dug by the local communities between the Early Copper Age and the Iron Age. These structures were interpreted as elements of a settlement mainly involved in primary production. The most remarkable structure is Well-N, radiocarbon and archaeologically dated to the Late Bronze Age, which has yielded large amounts of waterlogged plant remains, animal and fish bones and pottery. Despite the limited set of samples, the combination of macro-remain and pollen analyses in this unique context provides important information useful for exploring not only local subsistence systems but also human impact on the surrounding environment. Grapes and figs are the most abundant remains together with other fruits and edible vascular plants. Remains of melon and mulberry were identified being the earliest remains of these two species for Western Europe. Their presence may confirm early trade between Nuragic people and the eastern Mediterranean and/or African coasts. Intentional selection of wood suggests practices associated to the collection of raw material for specific technological demands. The presence of intestinal parasites in the pollen record points to the possible use of the well as a cesspit, at least in its later use, and this is one of the earliest evidence of this type of structures in prehistoric contexts. 相似文献
9.
Ganesh Kumar Agrawal Dominique Job Thomas Kieselbach Bronwyn J. Barkla Sixue Chen Renu Deswal Sabine Lüthje Ramesh Sundar Amalraj Georgia Tanou Bongani Kaiser Ndimba Rainer Cramer Wolfram Weckwerth Stefanie Wienkoop Michael J. Dunn Sun Tae Kim Yochiro Fukao Masami Yonekura Lello Zolla Jai Singh Rohila Rungaroon Waditee‐Sirisattha Antonio Masi Tai Wang Abhijit Sarkar Raj Agrawal Jenny Renaut Randeep Rakwal 《Proteomics》2013,13(21):3093-3100
The International Plant Proteomics Organization (INPPO) is a non‐profit organization whose members are scientists involved or interested in plant proteomics. Since the publication of the first INPPO highlights in 2012, continued progress on many of the organization's mandates/goals has been achieved. Two major events are emphasized in this second INPPO highlights. First, the change of guard at the top, passing of the baton from Dominique Job, INPPO founding President to Ganesh Kumar Agrawal as the incoming President. Ganesh K. Agrawal, along with Dominique Job and Randeep Rakwal initiated the INPPO. Second, the most recent INPPO achievements and future targets, mainly the organization of first the INPPO World Congress in 2014, tentatively planned for Hamburg (Germany), are mentioned. 相似文献
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