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Nazir Mamona Saleem Muhammad Ali Iftikhar Abbas Ghulam Rehman Najeeb Ur Green Ivan R. Hussain Wahid Khan Saima Hussain Hidayat 《Phytochemistry Reviews》2021,20(1):119-143
Phytochemistry Reviews - In the last decade the prevalence of diabetes has escalated globally and it is estimated that the number of diabetic people will increase to 642 million by 2040. Although... 相似文献
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Muhammad Saleem Natasha Shazmeen Mamona Nazir Naheed Riaz Gokhan Zengin Hafiz Muhammad Ataullah Qurat-ul-Ain Farrukh Nisar Mahreen Mukhtar Muhammad Imran Tousif 《化学与生物多样性》2021,18(12):e2100706
The present work describes medicinal potential and secondary metabolic picture of the methanol extract (PP-M) of Polygonum plebeium R.Br. and its fractions; hexane (PP-H), ethyl acetate (PP-E) and water (PP-W). In total bioactive component estimation, highest contents of phenolic (89.38±0.27 mgGAE/g extract) and flavonoid (51.21±0.43 mgQE/g extract) were observed in PP-E, and the same fraction exhibited the highest antioxidant potential in DPPH (324.80±4.09 mgTE/g extract), ABTS (563.18±11.39 mgTE/g extract), CUPRAC (411.33±15.49 mgTE/g extract) and FRAC (369.54±1.70 mgTE/g extract) assays. In Phosphomolybdenum activity assay, PP-H and PP-E showed nearly similar potential, however, PP-H was the most active (13.54±0.24 mgEDTAE/g extract) in metal chelating activity assay. PP-W was the stronger inhibitor (4.03±0.05 mgGALAE/g extract) of the enzyme AChE, while PP-H was potent inhibitor of BChE (5.62±0.27 mg GALAE/g extract). Interestingly, PP-E was inactive against BChE. Against tyrosinase activity, PP-E was again the most active fraction with inhibitory value of 71.89±1.44 mg KAE/g extract, followed by the activity of PP-M and PP-W. Antidiabetic potential was almost equally distributed among PP-M, PP-H and PP-E. For mapping the chemodiversity of P. plebeium, PP-M was analyzed through UHPLC/MS, which led to the identification of more than 50 compounds. Flavonoids were the main components derived from isovitexin, kaempferol and luteolin however, gallic acid, protocatechuic acid, gingerols and lyoniresinol 9′-sulfate were among important bioactive phenols. These findings prompted to conclude that Polygonum plebeium can be a significant source to offer new ingredient for nutraceuticals and functional foods. 相似文献
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Hussain Hidayat Nazir Mamona Saleem Muhammad Al-Harrasi Ahmed Elizbit Green Ivan R. 《Phytochemistry Reviews》2021,20(1):145-179
Phytochemistry Reviews - In recent years the prevalence of diabetes has increased globally and by 2040 the number of diabetic people has been estimated to increase to 642 million. Various classes... 相似文献
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