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Natalya Semenova Irina Madaeva Tatyana Bairova Sergey Kolesnikov Lubov Kolesnikova 《Chronobiology international》2013,30(10):1399-1408
ABSTRACTA comparative analysis of lipid peroxidation processes and antioxidant defense system in Caucasian menopausal women with/without insomnia depending on the genotype of Clock 3111T/C gene polymorphism was performed. Two hundred and fourteen Caucasian menopausal women divided into control (without insomnia) and main group (with insomnia) were examined. Lipid peroxidation (conjugated dienes, thiobarbituric acid reactants) and antioxidant defense system parameters (?-tocopherol, retinol, reduced and oxidized glutathione, glutathione S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase) were determined by spectrofluorophotometer and immunoenzymometric methods. Patients with insomnia carriers of the TT-genotype had a significantly higher thiobarbituric acid reactants level and glutathione peroxidase activity as compared to group with insomnia carriers of the minor 3111C-allele (p < .05). A comparative analysis of the parameters in the women of the main and control groups showed higher conjugated dienes, thiobarbituric acid reactants levels and lower retinol, reduced glutathione levels, glutathione reductase activity in women with insomnia carriers of the TT-genotype (p < .05). The carriers of the minor allele with insomnia had a higher conjugated dienes levels and lower glutathione peroxidase activity as compared to control (p < .05). Thus, lipid peroxidation and antioxidant system parameters in Caucasian menopausal women with insomnia depend on the Clock 3111T/C gene polymorphism. 相似文献
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Semenova N. V. Brichagina A. S. Madaeva I. M. Kolesnikova L. I. 《Journal of Evolutionary Biochemistry and Physiology》2022,58(4):971-978
Journal of Evolutionary Biochemistry and Physiology - The study aimed to evaluate the state of the enzymatic component of the glutathione system in peri- and postmenopausal women of the Russian and... 相似文献
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Natalya V. Semenova Irina M. Madaeva Tatiana A. Bairova Radzhana M. Zhambalova Leonid F. Sholokhov Luybov I. Kolesnikova 《Chronobiology international》2018,35(8):1066-1076
A comparative analysis of melatonin circadian rhythms in Caucasian (incoming population) and Asian (indigenous population) menopausal women with/without sleep disorders depending on the genotype of Clock 3111T/C gene polymorphism was realized.The melatonin level in the saliva was determined four times a day (6:00–7:00, 12:00–13:00, 18:00–19:00, 23:00–00:00 h). The Caucasian women—carriers of the TT-genotype with insomnia as compared to control group—had a higher morning melatonin level and a lower night melatonin level. The Asian women with TT-genotype and insomnia had a lower levels of melatonin as compared to control at daytime, evening and night. A significantly higher melatonin level in the early morning hours was detected in the Caucasian women—carriers of the TT-genotype with insomnia as compared to group womencarriers of the minor 3111C-allele. There were no statistically significant differences in the circadian rhythms of melatonin in the Asian women depending on the genotype of the Clock 3111T/C polymorphism. An assumption with respect to the protective role of the minor allele 3111C in the development of insomnia associated with the displacement of melatonin circadian rhythms in the representatives of the incoming population was made. 相似文献
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Madaeva Irina Berdina Olga Rychkova Liubov Bugun Olga 《Sleep and biological rhythms》2017,15(3):251-257
Sleep and Biological Rhythms - Sleep spindles may display a sleep protective function. Thus, their activity is also a stable marker of sleep disturbances. We investigated whether spindle activity... 相似文献
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Berdina Olga Madaeva Irina Bolshakova Svetlana Polyakov Vladimir Bugun Olga Rychkova Liubov 《Sleep and biological rhythms》2021,19(3):285-295
Sleep and Biological Rhythms - To evaluate specific features of sleep pattern and neurocognitive performance in OSA obese adolescents to correlate sleep macrostructural parameters and phasic events... 相似文献
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