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EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko 《Cell cycle (Georgetown, Tex.)》2015,14(22):3635-3643
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. 相似文献
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We present an efficient computational architecture designed using supervised machine learning model to predict amyloid fibril
forming protein segments, named AmylPepPred. The proposed prediction model is based on bio-physio-chemical properties of
primary sequences and auto-correlation function of their amino acid indices. AmylPepPred provides a user friendly web interface
for the researchers to easily observe the fibril forming and non-fibril forming hexmers in a given protein sequence. We expect that
this stratagem will be highly encouraging in discovering fibril forming regions in proteins thereby benefit in finding therapeutic
agents that specifically aim these sequences for the inhibition and cure of amyloid illnesses.
Availability
AmylPepPred is available freely for academic use at www.zoommicro.in/amylpeppred 相似文献6.
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Lupacheva NV 《Journal of physiological anthropology》2007,26(3):387-402
Complete anthropometrical data on a sample of 111 Russian males aged 20.0+/-2.3 years were obtained to investigate craniofacial morphology according to individual orthodontic status (OS). Subsample analyses were performed, using a variety of grouping factors. a) 1-spacing on both dental arches; 2-absence of crowding, spacing, rotation, or displacement of teeth on both dental arches; 3-crowding on both dental arches; b) 1-spacing on mandible; 2-absence of crowding, spacing, rotation, or displacement of teeth on mandible; 3-crowding on mandible; c) 1-spacing on maxilla; 2-absence of crowding, spacing, rotation, or displacement of teeth on maxilla; 3-crowding on maxilla. Wilks' Lambdas were found to be 0.29 to 0.59; all were significant. CONCLUSIONS: 1. Significant positive and negative correlations were found between craniofacial measurements and an individual's OS. 2. Measurements exhibited statistically significant differences between the groups with different OS at the p<0.05 level and some at p<0.01. 3. Using forward stepwise discriminant analysis, a high difference in craniofacial architecture between the groups with different OS was found. Canonical discriminant analysis indicates the face pattern connected to crowding: relatively high medial vertical mandible height in combination with a vertically long and narrow face; to spacing: a wide face with wide nose and high upper lip is combined with shortened medial vertical mandible height. 4. Depending upon the grouping factor, 10 to 12 variables were chosen in the canonical discriminant model. Classification functions and means of canonical roots were calculated; morphological interpretations of canonical roots were performed. 5. Definitive OS is a complicated product of interaction during the ontogenesis of jaws between the time of teeth eruption and the growth of two growth fields (alveolar and corpus) under the simultaneous influence of hormonal status and the chronological age of the individual. 相似文献
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Cyclooxygenases (COXs) catalyze the rate-limiting step in the production of prostaglandins, bioactive compounds involved in
processes such as fever and sensitivity to pain, and are the target of aspirin-like drugs. COX genes have been cloned from coral, tunicates and vertebrates, and in all the phyla where they are found, there are two genes
encoding two COX isoenzymes; it is unclear whether these genes arose from an early single duplication event or from multiple
independent duplications in evolution. The intron-exon arrangement of COX genes is completely conserved in vertebrates and mostly conserved in all species. Exon boundaries largely define the four
functional domains of the encoded protein: the amino-terminal hydrophobic signal peptide, the dimerization domain, the membrane-binding
domain, and the catalytic domain. The catalytic domain of each enzyme contains distinct peroxidase and cyclooxygenase active
sites; COXs are classified as members of the myeloperoxidase family. All COXs are homodimers and monotopic membrane proteins
(inserted into only one leaflet of the membrane), and they appear to be targeted to the lumenal membrane of the endoplasmic
reticulum, where they are N-glycosylated. In mammals, the two COX genes encode a constitutive isoenzyme (COX-1) and an inducible isoenzyme (COX-2); both are of significant pharmacological
importance. 相似文献
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Sabaté M Ligthart J Deshpande N DeFeyter P Serruys P 《International journal of cardiovascular interventions》1998,1(2):109-112
We report a case of implantation of a new design of stent which allows creation of a double-hemispheric lumen for the treatment of a bifurcational stenosis. The unfavourable outcome following the implantation of this stent is described. 相似文献
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In etiolated pea and maize leaves illuminated after incubation at 38 degreesC, a new dark reaction was shown manifested in the bathochromic shift of spectral bands and accompanied by esterification of the product of protochlorophyllide photochemical reduction--Chld 684/676: Chld 684/676 --> Chl 688/680. After completion of the reaction a rapid (20-30 sec) quenching of the fluorescence of the reaction product (Chl 688/680) was observed. The reaction Chld 684/676 --> Chl 688/680 is inhibited under anaerobic conditions and in the presence of cyanide; the reaction accompanied by Chl 688/680 fluorescence quenching is not observed in pea mutants with impaired function of photosystem II reaction centers. The spectral properties of the formed Chl form with the absorption maximum at 680 nm, fluorescence quenching, and simultaneous synthesis of pheophytin suggest that the reaction is connected with the chlorophyll of photosystem II reaction center--P-680. 相似文献