The Synthesis of Phosphates of Long-Chain ω-Hydroxyalkyl Esters of 11-Deoxyprostaglandin E1

Di(p-methylbenzyl) phosphates of -hydroxyalkyl esters of 11-deoxyprostaglandin E₁ were synthesized from disubstituted 1,10-decane and 1,22-docosane derivatives for studying the permeability of bilayer membranes.     

Effect of some organosilicon compounds (silatranes) on the biosynthesis of collagen in cartilagenous tissue of chick embryo]

Effect of some organosilicon compounds from the class of silatranes on the biosynthesis of collagen in cartilagenous tissue of chick embryos in vitro was studied. The criteria for assessing the intensity of collagen biosynthesis was the formation of peptide bond 14C-hydroxyproline from 14C-proline of incubation medium. All the compounds studied (methylsilatrane, ethoxysilatrane and chloromethylsilatrane) stimulated total protein biosynthesis and collagen biosynthesis in cartilagenous tissue of chick embryos. The most pronounced stimulation of the biosynthesis of collagen was observed at 3-10(-3) M concentration of silatranes within 180 min. of incubation (14C-proline was added to the incubation medium 60 min after the beginning of the incubation). The activity of partly purified collagen prolyl-hydroxylase in the presence of silatranes was also studied.     

The synthesis of phosphates of long-chain omega-hydroxyalkyl esters of 11-deoxyprostaglandin E1

Di(p-methylbenzyl) phosphates of omega-hydroxyalkyl esters of 11-deoxyprostaglandin E1 were synthesized from disubstituted 1,10-decane and 1,22-docosane derivatives for studying permeability of bilayer membranes. The English version of the paper.     

Stimulation with quaterin of DNA replication and repair

Quaterine [3-(2,2,3-trimethylhydrasinium)propionate] possessing a wide spectrum of physiological activity has been studied for its effect on the intensity of replicative and reparative DNA synthesis in different rat tissues (liver, thymus, heart, intestine mucosa and spleen) in order to investigate molecular mechanisms of its action. It is shown that the pronounced stimulation of DNA synthesis in all tissues, as a rule, takes place 1-6h after quaterine administration in doses of 25 and 100 mg/kg. The estimation of the given compound effect on DNA synthesis after its multiple administration to animals (for 5, 10, 15 days in a dose of 100 mg/kg) permits supposing that 3-(2,2,2-trimethylhydrasinium)propionate is able of providing either stable proliferation of cells (thymus, spleen) or their hyperplasia and polyploidization (heart, liver). The data obtained make it possible to explain (to some extent) quaterine ability to activate immune responses, to stimulate healing of wounds and burns.