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A.?V.?MarkovEmail author A.?V.?Sen’kova M.?A.?Zenkova E.?B.?Logashenko 《Molecular Biology》2018,52(2):262-268
Due to wide spreading of inflammatory disease and imperfection of available anti-inflammatory drugs, mainly associated with their serious side effects, searching for new anti-inflammatory agents is a pressing problem. Natural triterpenoids and their synthetic analogs are a promising source of new drugs. In this study, we have investigated the anti-inflammatory and antitumor effects in vivo of the glycyrrhetinic acid derivative soloxolone methyl (SM), or methyl 2-cyano-3,12-dioxo-18βH-olean-9(11),1(2)-dien-30-oate. SM was shown to efficiently suppress the development of edema in a mouse model of carrageenan- or histamine- induced acute inflammation. SM also inhibited the tumor growth and reduced the tumor cell count in the ascitic fluid in mice bearing Krebs-2 carcinoma, the development of which is accompanied by an inflammatory process in the surrounding tissues. 相似文献
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Markov A. V. Kupryushkin M. S. Goncharova E. P. Amirkhanov R. N. Vasilyeva S. V. Pyshnyi D. V. Zenkova M. A. Logashenko E. B. 《Russian Journal of Bioorganic Chemistry》2019,45(6):774-782
Russian Journal of Bioorganic Chemistry - The paper reports the synthesis of a series of antisense oligonucleotides (aONs) directed against different segments of the influenza A virus genome (H1N1)... 相似文献
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Irina I. Popadyuk Andrey V. Markov Valeriya O. Babich Oksana V. Salomatina Evgeniya B. Logashenko Marina A. Zenkova Nariman F. Salakhutdinov 《Bioorganic & medicinal chemistry letters》2017,27(16):3755-3759
A new library of deoxycholic acid derivatives bearing nitrogen-containing moieties at the C-3 position was synthesised from epoxy derivative 1 via an epoxide ring-opening reaction promoted by aliphatic or cyclic diamines and fully characterised by NMR and mass-spectroscopy. The synthesised compounds were screened for cytotoxicity against four human tumour cell lines. The results showed that some of the novel diamine-bearing derivatives displayed improved anti-proliferative activities over the parent compound DCA. Among them, a 1-methylpiperazine containing compound (6) showed promising activity and the highest selectivity against tumour cells of enterohepatic origin (HepG2: IC50 = 3.6 µM, SI = 9.0; HuTu-80: IC50 = 4.6 µM, SI = 6.9) and was identified as a lead molecule. 相似文献
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Silencing of MDR 1 gene in cancer cells by siRNA 总被引:3,自引:0,他引:3
Logashenko EB Vladimirova AV Repkova MN Venyaminova AG Chernolovskaya EL Vlassov VV 《Nucleosides, nucleotides & nucleic acids》2004,23(6-7):861-866
Inhibition of p-glycoprotein (PGP) expression and reverse of multidrug resistance (MDR) phenotype in KB-8-5 cells by synthetic 21-bp double-stranded oligoribonucleotides were investigated. siRNA constructs for the efficient down regulation of MDR1 that are active in nanomolar concentrations and cause reversal of MDR phenotype in cells were developed. 相似文献
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