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排序方式: 共有4111条查询结果,搜索用时 15 毫秒
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Shira Weingarten-Gabbay Susan Klaeger Siranush Sarkizova Leah R. Pearlman Da-Yuan Chen Kathleen M.E. Gallagher Matthew R. Bauer Hannah B. Taylor W. Augustine Dunn Christina Tarr John Sidney Suzanna Rachimi Hasahn L. Conway Katelin Katsis Yuntong Wang Del Leistritz-Edwards Melissa R. Durkin Christopher H. Tomkins-Tinch Pardis C. Sabeti 《Cell》2021,184(15):3962-3980.e17
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Protection of Mice against Lethal Coxsackievirus B3 Infection by Using DNA Immunization 总被引:27,自引:0,他引:27
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Andreas Henke Elke Wagner J. Lindsay Whitton Roland Zell Axel Stelzner 《Journal of virology》1998,72(10):8327-8331
Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient. 相似文献
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Rachael V. Gallagher Lesley Hughes Michelle R. Leishman Peter D. Wilson 《Biological invasions》2010,12(12):4049-4063
Potential interactions between climate change and exotic plant invasions may affect areas of high conservation value, such
as land set aside for the protection of endangered species or ecological communities. We investigated this issue in eastern
Australia using species distribution models for five exotic vines under climate regimes for 2020 and 2050. We examined how
projected changes in the distribution of climatically suitable habitat may coincide with the remaining remnants of an endangered
ecological community—littoral rainforests—in this region. The number of known infestations of each weed in tropical, subtropical
and temperate areas was used to assess the likelihood of further expansion into areas projected to provide suitable habitat
under future conditions. Littoral rainforest reserves were consistently predicted to provide bioclimatically suitable habitat
for the five vines examined under both current and future climate scenarios. We explore the consequences and potential strategies
for managing exotic plant invasions in these protected areas in the coming decades. 相似文献
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J.N. Beresford J.A. Gallagher M. Gowen M. Couch J. Poser D.D. Wood R.G.G. Russell 《Biochimica et Biophysica Acta (BBA)/General Subjects》1984,801(1):58-65
Cultural adherent human mononuclear cells produce factor(s) which stimulate the release of calcium from new-born mouse calvaria in organ culture. This stimulation of bone resorption is accompanied by an inhibition of the incorporation of [3H]proline into collagen which is independent of increased prostaglandin production by the bone. When human osteoblast-like cells are treated with conditioned medium from human mononuclear cells, collagen accounts for a decreased proportion of the protein synthesised. This effect on matrix synthesis is not accompanied by an inhibitory action of the monocyte-conditioned medium preparations on net cell proliferation. In human osteoblast-like cell cultures, partially purified human interleukin 1 also inhibits the production of the bone-specific protein osteocalcin in a dose-dependent fashion. These observations are consistent with the hypothesis that products of human monocytes similar to, or identical with, human interleukin 1 may be important regulators of bone metabolism and may contribute to the bone loss seen in diseases such as chronic rheumatoid arthritis. 相似文献
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Karen L. Lindsay Christian Hellmuth Olaf Uhl Claudia Buss Pathik D. Wadhwa Berthold Koletzko Sonja Entringer 《PloS one》2015,10(12)
Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and ultimately, infant health outcomes. However, our understanding of whole body maternal and fetal metabolism during this critical life stage remains incomplete. The objective of this study is to utilize metabolomics to profile longitudinal patterns of fasting maternal metabolites among a cohort of non-diabetic, healthy pregnant women in order to advance our understanding of changes in protein and lipid concentrations across gestation, the biochemical pathways by which they are metabolized and to describe variation in maternal metabolites between ethnic groups. Among 160 pregnant women, amino acids, tricarboxylic acid (TCA) cycle intermediates, keto-bodies and non-esterified fatty acids were detected by liquid chromatography coupled with mass spectrometry, while polar lipids were detected through flow-injected mass spectrometry. The maternal plasma concentration of several essential and non-essential amino acids, long-chain polyunsaturated fatty acids, free carnitine, acetylcarnitine, phosphatidylcholines and sphingomyelins significantly decreased across pregnancy. Concentrations of several TCA intermediates increase as pregnancy progresses, as well as the keto-body β-hydroxybutyrate. Ratios of specific acylcarnitines used as indicators of metabolic pathways suggest a decreased beta-oxidation rate and increased carnitine palmitoyltransferase-1 enzyme activity with advancing gestation. Decreasing amino acid concentrations likely reflects placental uptake and tissue biosynthesis. The absence of any increase in plasma non-esterified fatty acids is unexpected in the catabolic phase of later pregnancy and may reflect enhanced placental fatty acid uptake and utilization for fetal tissue growth. While it appears that energy production through the TCA cycle increases as pregnancy progresses, decreasing patterns of free carnitine and acetylcarnitine as well as increased carnitine palmitoyltransferase-1 rate and β-hydroxybutyrate levels suggest a concomitant upregulation of ketogenesis to ensure sufficient energy supply in the fasting state. Several differences in metabolomic profiles between Hispanic and non-Hispanic women demonstrate phenotypic variations in prenatal metabolism which should be considered in future studies. 相似文献
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