全文获取类型
收费全文 | 102篇 |
免费 | 2篇 |
出版年
2021年 | 3篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 6篇 |
2016年 | 3篇 |
2015年 | 4篇 |
2014年 | 5篇 |
2013年 | 6篇 |
2012年 | 6篇 |
2011年 | 9篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 4篇 |
2007年 | 2篇 |
2006年 | 7篇 |
2005年 | 1篇 |
2004年 | 4篇 |
2003年 | 5篇 |
2002年 | 5篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有104条查询结果,搜索用时 15 毫秒
1.
2.
Abramov I. S. Korneva Yu. S. Shisterova O. A. Ikonnikova A. Yu. Emelyanova M. A. Lisitsa T. S. Krasnov G. S. Nasedkina T. V. 《Molecular Biology》2021,55(3):354-362
Molecular Biology - Molecular profiling of tumors may provide promising options for personalized treatment. We have examined the spectrum of germline and somatic mutations in 23 breast cancers (BC)... 相似文献
3.
Lidiya Stavitskaya Michael J. Seminerio Jason R. Healy Bahar Noorbakhsh Rae R. Matsumoto Andrew Coop 《Bioorganic & medicinal chemistry》2013,21(17):4923-4927
A series of ring-constrained phenylpropyloxyethylamines, partial opioid structure analogs and derivatives of a previously studied sigma (σ) receptor ligand, was synthesized and evaluated at σ and opioid receptors for receptor selectivity. The results of this study identified several compounds with nanomolar affinity at both σ receptor subtypes. Compounds 6 and 9 had the highest selectivity for both σ receptor subtypes, compared to μ opioid receptors. In addition, compounds 6 and 9 significantly reduced the convulsive effects of cocaine in mice, which would be consistent with antagonism of σ receptors. 相似文献
4.
5.
Lectins LI and LII, localized on the surface of the nitrogen-fixing soil bacterium Bacillus polymyxa 1460, were shown to possess proteolytic activity. A relationship was found between the proteolytic and hemagglutinating activities
of the lectins. Blocking of hemagglutinating activity with specific carbohydrate haptens led to significant changes in the
enzyme activity of both lectins. When lectin activity was blocked with glucuronic acid and fructose-1,6-diphosphate, the proteolytic
activity of both LI and LII declined, whereas incubation with d-galactosamine and d-glucosamine promoted increases in the
proteolytic activity of LII. This study proposes that the molecules of the B. polymyxa lectins may have two centers on their surfaces: one responsible for lectin activity and the other for proteolytic activity.
Received: 27 March 2000 / Accepted: 26 April 2000 相似文献
6.
Lidiya Stavitskaya Michael J. Seminerio Marilyn M. Matthews-Tsourounis Rae R. Matsumoto Andrew Coop 《Bioorganic & medicinal chemistry letters》2010,20(8):2564-2565
A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the σ1 and σ2 receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor σ1 receptors, while previously studied (2-pyridyl)piperazines favor σ2 receptors. 相似文献
7.
Bohdan Ostash Alexander Shashkov Galina Streshinskaya Elena Tul’skaya Lidiya Baryshnikova Andrey Dmitrenok Yuriy Dacyuk Victor Fedorenko 《Folia microbiologica》2014,59(4):355-360
The cell wall of the model actinomycete Streptomyces coelicolor M145 has recently been shown to contain the novel glycopolymer teichulosonic acid. The major building block of this polymer is 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (Kdn), suggesting initial clues about the genetic control of biosynthesis of this cell wall component. Here, through genome mining and gene knockouts, we demonstrate that the sco4879–sco4882 genomic region of S. coelicolor M145 is necessary for biosynthesis of teichulosonic acid. Specifically, mutants carrying individual knockouts of sco4879, sco4880 and sco4881 genes do not produce Kdn-containing glycopolymer and instead accumulate the minor cell wall component poly(diglycosyl 1-phosphate). Our studies provide evidence that this region is at least partly responsible for biosynthesis of Kdn, whereas flanking genes might control the other steps of teichulosonic acid formation. 相似文献
8.
Lyudmila Baranova Valentina Emelyanova Igor Volotovski 《Molecular biology reports》2010,37(6):2727-2733
Amplification and a cloning of fragments of genes of human retina tyrosine kinases, the nucleotide sequences of which feature
a high homology to the gene families of the Yes and Csk tyrosine kinases, and a cloning of the complete coding sequence of
the cDNA of the Csk tyrosine kinase gene of the human lymphocytes have been carried out. It has been established that this
sequence contains 1,624 bp and encodes a protein that, with a 99% homology, corresponds to the human tyrosine kinase. A comparative
analysis of the nucleotide sequences of the full-size cDNA of the Csk tyrosine kinase of the lymphocytes of healthy donors
and of patients with an eye choroidal melanoma has shown that a risk of development of an eye choroidal melanoma can be estimated
by the frequency of occurrence of a mutant allele in the 10th exon. 相似文献
9.
Emelyanova M. A. Amossenko F. A. Semyanikhina A. V. Aliev V. A. Barsukov Yu. A. Lyubchenko L. N. Nasedkina T. V. 《Molecular Biology》2015,49(4):550-559
Molecular Biology - Somatic mutations of KRAS, PIK3CA, and BRAF cause insensitivity of colorectal tumors to therapy with anti-EGFR monoclonal antibodies, necessitating a genetic testing prior to... 相似文献
10.
Control of static balance was studied in wrestlers (n = 31) in the normal state and against the background of physical fatigue, i.e., before and after a bicycle PWC
170 test, respectively. The static balance was evaluated using a Ritm force platform (Russia) during normal basic stance (BS)
and static strain (half-squatting position (HS) with the eyes open). Before physical exercise, i.e., during BS, the differences
in postural control of the center of pressure (CP) between athletes and control subjects (n = 40) were nonsignificant. In the HS position, both linear and angular sway velocities of CP (LSV and ASV, respectively)
were significantly lower in wrestlers (p < 0.001), and these parameters were negatively correlated with the PWC
170 index (r = −0.454 and r = −455, p < 0.001 for LSV and ASV, respectively), which suggests that up to 20% of the sway velocity variance during static strain
is dependent on the working capacity of the subjects. After the PWC
170 test, the sway velocities of CP increased in both groups during BS (p < 0.01) and HS (p < 0.001), which testifies to the important role of muscular fatigue in the decrease in postural stability in both groups.
During BS, an increase in LSV and ASV was about the same in both groups; however, during HS, an increase in the sway velocities
of CP after PWC
170 was lower in wrestlers (the intergroup differences at p = 0.037 and p = 0.008 for LSV and ASV, respectively); this parameter was negatively correlated with the recovery of the heart rate (HR)
after the bicycle test (r = −0.378, p < 0.001 and r = −0.265, p < 0.05 for LSV and ASV, respectively), which suggests that rapid recovery contributes to a certain extent (about 6.5–14.2%)
to the postural stability during static strain of wrestlers against the background of their physical fatigue. 相似文献