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排序方式: 共有117条查询结果,搜索用时 15 毫秒
1.
Olga M. Tsivileva Valentina E. Nikitina Lidiya V. Garibova Vladimir V. Ignatov 《International microbiology》2001,4(1):41-45
The hemagglutinating activity of submerged mycelium and culture liquid for four strains of Lentinus edodes (Berk.) Sing [L. edodes (Berk.) Pegler] was studied in the search for lectins. The hemagglutinating activity of culture liquid was substantially higher, compared with mycelium. The carbohydrate-binding capacity of the agglutinins was established, and the lectin activity of extracts from mycelia grown on several agar media was elucidated in relation to fruiting. The lectin activity of L. edodes was examined at different morphogenetic steps: mycelium, brown mycelial film, primordium, and fruiting body. Hemagglutination titers at the brown film step were higher than in the mycelium, whereas activity at the primordial and fruiting bodies steps decreased. Lectins seem to be involved in the formation of hyphal aggregates of brown mycelial film. 相似文献
2.
V. A. Alexandrova N. S. Domnina G. P. Snigireva 《Applied Biochemistry and Microbiology》2016,52(5):491-495
It was shown using various methods that the radical scavenging and radical scavenging activities of chitosan conjugates with phenolic antioxidants of plant origin significantly exceed the corresponding values of their low molecular weight analogs (gallic and syringic acids, quercetin and dihydroquercetin). Cytogenetic analysis of human peripheral blood lymphocytes demonstrated that the conjugates showed pronounced antimutagenic efficiency when the cells were γ-irradiated in vitro at a dose of 2 Gy. 相似文献
3.
Lidiya Stavitskaya Michael J. Seminerio Jason R. Healy Bahar Noorbakhsh Rae R. Matsumoto Andrew Coop 《Bioorganic & medicinal chemistry》2013,21(17):4923-4927
A series of ring-constrained phenylpropyloxyethylamines, partial opioid structure analogs and derivatives of a previously studied sigma (σ) receptor ligand, was synthesized and evaluated at σ and opioid receptors for receptor selectivity. The results of this study identified several compounds with nanomolar affinity at both σ receptor subtypes. Compounds 6 and 9 had the highest selectivity for both σ receptor subtypes, compared to μ opioid receptors. In addition, compounds 6 and 9 significantly reduced the convulsive effects of cocaine in mice, which would be consistent with antagonism of σ receptors. 相似文献
4.
A. P. Domnina P. V. Novikova I. I. Fridlyanskaya M. A. Shilina V. V. Zenin N. N. Nikolsky 《Cell and Tissue Biology》2016,10(2):95-99
In this study, we compared the ability of human mesenchymal stem cells (eMSCs) derived from menstrual blood and mesenchymal stem cells (MSCs) from other tissues to differentiate into decidual cells in vitro. It was demonstrated that, during differentiation, secretion of prolactin and insulin-like growth factor binding protein-1 (key decidualization markers) markedly increased in eMSCs slightly augmented in bone marrow MSC (BM-MSCs) and did not change in MSCs from adipose tissue (AT-MSCs). Thus, eMSCs exhibited higher capacity for differentiation into decidual cells than BM-MSCs or AT-MSCs. This makes eMSCs promising for application in cellular therapy of infertility associated with insufficient decidualization of endometrium. 相似文献
5.
6.
Lectins LI and LII, localized on the surface of the nitrogen-fixing soil bacterium Bacillus polymyxa 1460, were shown to possess proteolytic activity. A relationship was found between the proteolytic and hemagglutinating activities
of the lectins. Blocking of hemagglutinating activity with specific carbohydrate haptens led to significant changes in the
enzyme activity of both lectins. When lectin activity was blocked with glucuronic acid and fructose-1,6-diphosphate, the proteolytic
activity of both LI and LII declined, whereas incubation with d-galactosamine and d-glucosamine promoted increases in the
proteolytic activity of LII. This study proposes that the molecules of the B. polymyxa lectins may have two centers on their surfaces: one responsible for lectin activity and the other for proteolytic activity.
Received: 27 March 2000 / Accepted: 26 April 2000 相似文献
7.
Lidiya Stavitskaya Michael J. Seminerio Marilyn M. Matthews-Tsourounis Rae R. Matsumoto Andrew Coop 《Bioorganic & medicinal chemistry letters》2010,20(8):2564-2565
A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the σ1 and σ2 receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor σ1 receptors, while previously studied (2-pyridyl)piperazines favor σ2 receptors. 相似文献
8.
Bohdan Ostash Alexander Shashkov Galina Streshinskaya Elena Tul’skaya Lidiya Baryshnikova Andrey Dmitrenok Yuriy Dacyuk Victor Fedorenko 《Folia microbiologica》2014,59(4):355-360
The cell wall of the model actinomycete Streptomyces coelicolor M145 has recently been shown to contain the novel glycopolymer teichulosonic acid. The major building block of this polymer is 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (Kdn), suggesting initial clues about the genetic control of biosynthesis of this cell wall component. Here, through genome mining and gene knockouts, we demonstrate that the sco4879–sco4882 genomic region of S. coelicolor M145 is necessary for biosynthesis of teichulosonic acid. Specifically, mutants carrying individual knockouts of sco4879, sco4880 and sco4881 genes do not produce Kdn-containing glycopolymer and instead accumulate the minor cell wall component poly(diglycosyl 1-phosphate). Our studies provide evidence that this region is at least partly responsible for biosynthesis of Kdn, whereas flanking genes might control the other steps of teichulosonic acid formation. 相似文献
9.
10.
B. V. Chernyak Y. N. Antonenko E. R. Galimov L. V. Domnina V. B. Dugina R. A. Zvyagilskaya O. Yu. Ivanova D. S. Izyumov K. G. Lyamzaev A. V. Pustovidko T. I. Rokitskaya A. G. Rogov I. I. Severina R. A. Simonyan M. V. Skulachev V. N. Tashlitsky E. V. Titova T. A. Trendeleva G. S. Shagieva 《Biochemistry. Biokhimii?a》2012,77(9):983-995
Novel mitochondria-targeted compounds composed entirely of natural constituents have been synthesized and tested in model lipid membranes, in isolated mitochondria, and in living human cells in culture. Berberine and palmatine, penetrating cations of plant origin, were conjugated by nonyloxycarbonylmethyl residue with the plant electron carrier and antioxidant plastoquinone. These conjugates (SkQBerb, SkQPalm) and their analogs lacking the plastoquinol moiety (C10Berb and C10Palm) penetrated across planar bilayer phospholipid membrane in their cationic forms and accumulated in isolated mitochondria or in mitochondria in living human cells in culture. Reduced forms of SkQBerb and SkQPalm inhibited lipid peroxidation in isolated mitochondria at nanomolar concentrations. In isolated mitochondria and in living cells, the berberine and palmatine moieties were not reduced, so antioxidant activity belonged exclusively to the plastoquinol moiety. In human fibroblasts, nanomolar SkQBerb and SkQPalm prevented fragmentation of mitochondria and apoptosis induced by exogenous hydrogen peroxide. At higher concentrations, conjugates of berberine and palmatine induced proton transport mediated by free fatty acids both in model and in mitochondrial membrane. In mitochondria this process was facilitated by the adenine nucleotide carrier. As an example of application of the novel mitochondria-targeted antioxidants SkQBerb and SkQPalm to studies of signal transduction, we discuss induction of cell cycle arrest, differentiation, and morphological normalization of some tumor cells. We suggest that production of oxygen radicals in mitochondria is necessary for growth factors-MAP-kinase signaling, which supports proliferation and transformed phenotype. 相似文献