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1.
High level of divergence of male-reproductive-tract proteins, between Drosophila melanogaster and its sibling species, D. simulans 总被引:1,自引:0,他引:1
We compared male-reproductive-tract polypeptides of Drosophila melanogaster
and D. simulans by using two-dimensional gel electrophoresis. Approximately
64% of male-reproductive-tract polypeptides were identical between two
randomly chosen isofemale lines from these two species, compared with 83%
identity for third-instar imaginal wing-disc polypeptides. Qualitatively
similar differences were found between reproductive tracts and imaginal
discs when D. sechellia was compared with D. melanogaster and with D.
simulans. When genic polymorphism was taken into account, approximately 10%
of male- reproductive-tract polypeptides were apparently fixed for
different alleles between D. melanogaster and D. simulans; this proportion
is the same as that found for soluble enzymes by one-dimensional gel
electrophoresis. Strikingly, approximately 20% of male-reproductive- tract
polypeptides of either D. melanogaster or D. simulans had no detectable
homologue in the other species. We propose that proteins of the Drosophila
male reproductive tract may have diverged more extensively between species
than have other types of proteins and that much of this divergence may
involve large changes in levels of polypeptide expression.
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2.
Allemann Y Sartori C Lepori M Pierre S Mélot C Naeije R Scherrer U Maggiorini M 《American journal of physiology. Heart and circulatory physiology》2000,279(4):H2013-H2016
Exaggerated hypoxia-induced pulmonary hypertension is a hallmark of high-altitude pulmonary edema (HAPE) and plays a major role in its pathogenesis. Many studies of HAPE have estimated systolic pulmonary arterial pressure (SPAP) with Doppler echocardiography. Whereas at low altitude, Doppler echocardiographic estimation of SPAP correlates closely with its invasive measurement, no such evidence exists for estimations obtained at high altitude, where alterations of blood viscosity may invalidate the simplified Bernoulli equation. We measured SPAP by Doppler echocardiography and invasively in 14 mountaineers prone to HAPE and in 14 mountaineers resistant to this condition at 4,559 m. Mountaineers prone to HAPE had more pronounced pulmonary hypertension (57 +/- 12 and 58 +/- 10 mmHg for noninvasive and invasive determination, respectively; means +/- SD) than subjects resistant to HAPE (37 +/- 8 and 37 +/- 6 mmHg, respectively), and the values measured in the two groups as a whole covered a wide range of pulmonary arterial pressures (30-83 mmHg). Spearman test showed a highly significant correlation (r = 0.89, P < 0.0001) between estimated and invasively measured SPAP values. The mean difference between invasively measured and Doppler-estimated SPAP was 0.5 +/- 8 mmHg. At high altitude, estimation of SPAP by Doppler echocardiography is an accurate and reproducible method that correlates closely with its invasive measurement. 相似文献
3.
Markus K Muellner Barbara Mair Yasir Ibrahim Claudia Kerzendorfer Hannelore Lechtermann Claudia Trefzer Freya Klepsch André C Müller Ernestine Leitner Sabine Macho‐Maschler Giulio Superti‐Furga Keiryn L Bennett José Baselga Uwe Rix Stefan Kubicek Jacques Colinge Violeta Serra Sebastian MB Nijman 《Molecular systems biology》2015,11(2)
4.
Lepori MB Lovicu M Dessi V Zappu A Incollu S Zancan L Giacchino R Iorio R Vajro P Maggiore G Marcellini M Barbera C Pellecchia MT Simonetti R Kostic V Farci AM Solinas A De Virgiliis S Cao A Loudianos G 《Genetic testing》2007,11(3):328-332
Herein we report the results of mutation analysis of the ATP7B gene in a group of 134 Wilson disease (WD) families (268 chromosomes) prevalently of Italian origin. Using the SSCP and sequencing methods we identified 71 disease-causing mutations. Twenty-four were novel, while 19 more mutations already described, were identified in new populations in this study. A known mutation G591D showed a regional distribution, since it was only detected in 38.5% of the analyzed chromosomes in WD patients originating from Apulia, a region of South Italy. Detection of new mutations in the ATP7B gene increases our capability of molecular analysis that is essential for early diagnosis and treatment of WD. 相似文献
5.
Forecasting Environmental Responses to Restoration of Rivers Used as Log Floatways: An Interdisciplinary Challenge 总被引:1,自引:0,他引:1
Christer Nilsson Fabio Lepori Björn Malmqvist Erik Törnlund Niclas Hjerdt James M. Helfield Daniel Palm Johan Östergren Roland Jansson Eva Brännäs Hans Lundqvist 《Ecosystems》2005,8(7):779-800
Log floating in the 19th to mid 20th centuries has profoundly changed the environmental conditions in many northern river
systems of the world. Regulation of flow by dams, straightening and narrowing of channels by various piers and wing dams,
and homogenization of bed structure are some of the major impacts. As a result, the conditions for many riverine organisms
have been altered. Removing physical constructions and returning boulders to the channels can potentially restore conditions
for these organisms. Here we describe the history of log driving, review its impact on physical and biological conditions
and processes, and predict the responses to restoration. Reviewing the literature on comparable restoration efforts and building
upon this knowledge, using boreal Swedish rivers as an example, we address the last point. We hypothesize that restoration
measures will make rivers wider and more sinuous, and provide rougher bottoms, thus improving land-water interactions and
increasing the retention capacity of water, sediment, organic matter and nutrients. The geomorphic and hydraulic/hydrologic
alterations are supposed to favor production, diversity, migration and reproduction of riparian and aquatic organisms. The
response rates are likely to vary according to the types of processes and organisms. Some habitat components, such as beds
of very large boulders and bedrock outcrops, and availability of sediment and large woody debris are believed to be extremely
difficult to restore. Monitoring and evaluation at several scales are needed to test our predictions. 相似文献
6.
7.
Two MC1R loss‐of‐function alleles in cream‐coloured Australian Cattle Dogs and white Huskies 下载免费PDF全文
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10.
Cytochrome P-448 (mol wt 55,000 Daltons) from rabbit liver was purified to a specific content of 16.6 nmol/mg. Mice were immunised with this preparation, their spleens removed and dissociated lymphocytes hybridised with myeloma cells. Four monoclonal antibodies against cytochrome P-448 were raised and partially characterised. All four antibodies interacted with cytochrome P-448 in intact microsomal fractions and selectively immunoadsorbed cytochrome P-448 from solubilised microsomal preparations. One of the antibodies inhibited benzo[a] pyrene hydroxylase activity in a reconstituted system, one had no effect on activity and two increased activity. The possible applications of such antibodies are discussed. 相似文献