全文获取类型
收费全文 | 4361篇 |
免费 | 355篇 |
出版年
2022年 | 28篇 |
2021年 | 61篇 |
2020年 | 45篇 |
2019年 | 39篇 |
2018年 | 67篇 |
2017年 | 54篇 |
2016年 | 110篇 |
2015年 | 159篇 |
2014年 | 174篇 |
2013年 | 259篇 |
2012年 | 328篇 |
2011年 | 345篇 |
2010年 | 205篇 |
2009年 | 203篇 |
2008年 | 285篇 |
2007年 | 277篇 |
2006年 | 276篇 |
2005年 | 245篇 |
2004年 | 234篇 |
2003年 | 244篇 |
2002年 | 245篇 |
2001年 | 42篇 |
2000年 | 34篇 |
1999年 | 47篇 |
1998年 | 61篇 |
1997年 | 40篇 |
1996年 | 39篇 |
1995年 | 37篇 |
1994年 | 35篇 |
1993年 | 28篇 |
1992年 | 26篇 |
1991年 | 21篇 |
1990年 | 30篇 |
1989年 | 19篇 |
1988年 | 14篇 |
1987年 | 16篇 |
1986年 | 10篇 |
1985年 | 18篇 |
1984年 | 20篇 |
1983年 | 17篇 |
1982年 | 19篇 |
1981年 | 18篇 |
1980年 | 11篇 |
1979年 | 16篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1976年 | 17篇 |
1975年 | 12篇 |
1974年 | 16篇 |
1972年 | 13篇 |
排序方式: 共有4716条查询结果,搜索用时 15 毫秒
1.
Willoughby de Broke Rudyard Kipling Hugh Elliot E. Ray Lankester Leonard Hill Laurence R. Philipps Wm. Arbuthnot Lane James Crichton-Browne H. Bryan Donkin Francis Lloyd R. A. Lyster John MacAlister F. W. Mott William Osler C. W. Saleeby J. H. Sequeira Humphry Rolleston Hugh Wansey Bayly 《BMJ (Clinical research ed.)》1919,2(3074):725
2.
Thermosensation provides vital inputs for the malaria vector mosquito, Anopheles gambiae which utilizes heat-sensitivity within a broad spectrum of behaviors, most notably, the localization of human hosts for blood feeding. In this study, we examine thermosensory behaviors in larval-stage An. gambiae, which as a result of their obligate aquatic habitats and importance for vectorial capacity, represents an opportunistic target for vector control as part of the global campaign to eliminate malaria. As is the case for adults, immature mosquitoes respond differentially to a diverse array of external heat stimuli. In addition, larvae exhibit a striking phenotypic plasticity in thermal-driven behaviors that are established by temperature at which embryonic development occurs. Within this spectrum, RNAi-directed gene-silencing studies provide evidence for the essential role of the Transient Receptor Potential sub-family A1 (TRPA1) channel in mediating larval thermal-induced locomotion and thermal preference within a discrete upper range of ambient temperatures. 相似文献
3.
Laurence J. Dorr 《Brittonia》1994,46(1):62-65
Notes that augment an earlier essay on R. S. Williams’ botanical activities and the distribution of his collections from Bolivia and Peru are presented. Twelve species based on Williams’ vascular plant collections are added to a catalog that was previously published. Synonymies of an additional 22 taxa are corrected or updated. Notes also are provided concerning the typification or orthography of two species. 相似文献
4.
Sabrina Forveille Heng Zhou Allan Sauvat Lucillia Bezu Kevin Müller Peng Liu Laurence Zitvogel Gérard Pierron ?ystein Rekdal Oliver Kepp Guido Kroemer 《Cell cycle (Georgetown, Tex.)》2015,14(21):3506-3512
The oncolytic peptide LTX-315 has been designed for killing human cancer cells and turned out to stimulate anti-cancer immune responses when locally injected into tumors established in immunocompetent mice. Here, we investigated the question whether LTX-315 induces apoptosis or necrosis. Transmission electron microscopy or morphometric analysis of chromatin-stained tumor cells revealed that LTX-315 failed to induce apoptotic nuclear condensation and rather induced a necrotic phenotype. Accordingly, LTX-315 failed to stimulate the activation of caspase-3, and inhibition of caspases by means of Z-VAD-fmk was unable to reduce cell killing by LTX-315. In addition, 2 prominent inhibitors of regulated necrosis (necroptosis), namely, necrostatin-1 and cycosporin A, failed to reduce LTX-315-induced cell death. In conclusion, it appears that LTX-315 triggers unregulated necrosis, which may contribute to its pro-inflammatory and pro-immune effects. 相似文献
5.
6.
Laurence A. Greenbaum 《The Yale journal of biology and medicine》1987,60(1):54-Feb;60(1):54
7.
Homozygous paracentric inversion 12 in a mentally retarded boy: a case report and review of the literature 总被引:1,自引:1,他引:0
Summary A mentally retarded male was found to be homozygous for a paracentric inversion of the long arm of chromosome 12(inv(12)(q21.1q23.2)). His parents, who are first cousins, and his phenotypically normal younger brother are inversion heterozygotes. Homozygous structural rearrangements are discussed and cases of paracentric inversions, including a further nine previously unpublished, are reviewed. 相似文献
8.
Forty-four chromosome counts from the North American genusCallirhoe are reported, including first-recorded counts ofC. alcaeoides, C. digitata, C. bushii, C. triangulata, andC. involucrata var.tenuissima. Information concerning chromosome numbers from present and previous reports is summarized and evaluated. Observations are presented on meiosis for the genus in general, for male sterile individuals of gynodioecious species, and for selected F1 hybrids. Pollen fertility data are recorded for the latter. Chromosomally three species groups are recognized: an exinvolucellate, diploid species group withn=14; an involucellate, tetraploid and octoploid species pair,n=28 and 56; and an involucellate, diploid and tetraploid species group withn=15 and 30. Intrageneric relationships and those within the tribe Malveae subtribe Malvinae are discussed. 相似文献
9.
10.
I Gáti M Bergstr?m K Csóka C Muhr J Carlsson 《Prostaglandins, leukotrienes, and essential fatty acids》1990,40(2):117-124
The effects of two specific 5-lipoxygenase inhibitors AA-863 and U-60,257 (piriprost) on the growth of two human glioma cell lines, U-343 MGa and U-251 MG were investigated. Both monolayer cultured cells and spheroids were studied. The results of the monolayer studies showed potent and dose dependent inhibitory effects on the proliferation of glioma cells (IC50/one week treatment/of AA-863: 9.0 microM, IC50 of U-60,257: 40.0 microM). The experiments made on the tumor spheroids suggested an inhibitory effect on proliferation and volume growth already at lower doses (AA-863: 0.4-2.0 microM, U-60,257: 1.0-5.0 microM), a dose range where effects were not found in monolayers. At higher doses (AA-863: 10.0-30.0 microM, U-60,257: 30.0-90.0 microM) the experiments with spheroids failed to demonstrate a further inhibitory effect on spheroid volume, probably attributed to phenomena such as swelling of cells, dissociation of spheroid structure and development of necrosis. The clearly dose dependent inhibitory effect on the proliferation of human glioma cells in monolayer culture and the inhibitory effects on spheroid growth with these specific inhibitors indicate a role for lipoxygenase products in the growth of gliomas. 相似文献