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Larussa T Suraci E Leone I Nazionale I Abenavoli L Galasso O Amorosi A Imeneo M Luzza F 《Helicobacter》2010,15(5):449-459
Background: Selective cyclooxygenase‐2 (COX‐2) inhibitors and proton pump inhibitors may exert immune‐mediated effects in human gastric mucosa. T‐cell immune response plays a role in Helicobacter pylori‐induced pathogenesis. This study evaluated effects of celecoxib and lansoprazole on T‐helper (Th) 1 and Th2 immune response in human gastric mucosa. Methods: Dyspeptic patients with or without osteoarticular pain were given one of the following 4‐week therapies: celecoxib 200 mg, celecoxib 200 mg plus lansoprazole 30 mg, and lansoprazole 30 mg daily. Expression of COX‐2, T‐bet, and pSTAT6 and production of prostaglandin E2 (PGE2), interferon (IFN)‐γ, and interleukin (IL)‐4 were determined in gastric biopsies before and after therapy. Histology was evaluated. Results: Cyclooxygenase‐2 expression and PGE2 production was higher, and Th1 signaling pathway was predominant in H. pylori‐infected vs. uninfected patients. T‐bet expression and IFN‐γ production increased, while STAT6 activation and IL‐4 production decreased following therapy with celecoxib and celecoxib plus lansoprazole, respectively. Th1 and Th2 signaling pathways down‐regulated after therapy with lansoprazole, and this was associated with an improvement of gastritis. Effect of therapy was not affected by H. pylori status. Conclusion: Celecoxib and lansoprazole modulate Th1/Th2 immune response in human gastric mucosa. The use of these drugs may interfere with long‐term course of gastritis. 相似文献
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Enhanced Expression of Indoleamine 2,3‐Dioxygenase in Helicobacter pylori‐Infected Human Gastric Mucosa Modulates Th1/Th2 Pathway and Interleukin 17 Production
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Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism,bacterial virulence factor CagA,and gender of patients
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Sabzevary-Ghahfarokhi Milad Soltani Amin Luzza Francesco Larussa Tiziana Rahimian Ghorbanali Shirzad Hedayatollah Bagheri Nader 《Molecular biology reports》2020,47(9):6941-6947
Molecular Biology Reports - Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with increasing incidence and prevalence in developed countries. The presence of inflammatory cytokines is... 相似文献
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Sea cucumbers, Stichopus moebii, have a unique specialization of their blood vascular system: The vascular follicle network is composed of numerous small chambers (follicles) interconnected by minute vessels. The fine structure of the follicle system was studied in detail. The follicles are composed of several layers: an external ciliated epithelium, neuromuscular layer and basement membrane, connective tissue, and a fenestrated endothelial lining. The follicle lumen is filled with coelomocytes and necrotic cells surrounding particles of iron. The follicle may function in coelomocyte production and destruction. 相似文献
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