排序方式: 共有13条查询结果,搜索用时 13 毫秒
1.
A quantitative method for investigation of relationship between polygenic and monogenic traits has been proposed. It is based on examination of relationship between frequencies of distribution classes of an adaptive quantitative trait and frequencies of certain genetic character in the same classes. The method permits to locate a gene marker within a space of quantitative trait values. Using adaptively significant morpho-anatomic traits, it is possible to estimate indirectly adaptive values of gene markers under consideration, since, in accordance with the concept of adaptive norm, "average" phenotypes have maximal fitness, whereas deviative phenotypes transgress the bounds of the optimum. As a genetical character, genotype of certain biochemical locus, individual heterozygosity range or interlocus combinations of alleles could be used. The method has been applied to newborn Astrakhan lambs. Principal component analysis has been used to obtain complex characterization for six constitutional characters. Some regularities in location of homo- and heterozygous genotypes of the transferrin locus within a space of morphological characters' values have been revealed. 相似文献
2.
Felde Vivian A. Flantua Suzette G. A. Jenks Cathy R. Benito Blas M. de Beaulieu Jacques-Louis Kuneš Petr Magri Donatella Nalepka Dorota Risebrobakken Bjørg ter Braak Cajo J. F. Allen Judy R. M. Granoszewski Wojciech Helmens Karin F. Huntley Brian Kondratienė Ona Kalniņa Laimdota Kupryjanowicz Mirosława Malkiewicz Małgorzata Milner Alice M. Nita Małgorzata Noryśkiewicz Bożena Pidek Irena A. Reille Maurice Salonen J. Sakari Šeirienė Vaida Winter Hanna Tzedakis Polychronis C. Birks H. John B. 《Vegetation History and Archaeobotany》2020,29(1):101-109
Vegetation History and Archaeobotany - The Eemian interglacial represents a natural experiment on how past vegetation with negligible human impact responded to amplified temperature changes... 相似文献
3.
Markus Sällman Almén Emil K. Nilsson Josefin A. Jacobsson Ineta Kalnina Janis Klovins Robert Fredriksson Helgi B. Schiöth 《Gene》2014
The combination of the obesity epidemic and an aging population presents growing challenges for the healthcare system. Obesity and aging are major risk factors for a diverse number of diseases and it is of importance to understand their interaction and the underlying molecular mechanisms. Herein the authors examined the methylation levels of 27578 CpG sites in 46 samples from adult peripheral blood. The effect of obesity and aging was ascertained with general linear models. More than one hundred probes were correlated to aging, nine of which belonged to the KEGG group map04080. Additionally, 10 CpG sites had diverse methylation profiles in obese and lean individuals, one of which was the telomerase catalytic subunit (TERT). In eight of ten cases the methylation change was reverted between obese and lean individuals. One region proved to be differentially methylated with obesity (LINC00304) independent of age. This study provides evidence that obesity influences age driven epigenetic changes, which provides a molecular link between aging and obesity. This link and the identified markers may prove to be valuable biomarkers for the understanding of the molecular basis of aging, obesity and associated diseases. 相似文献
4.
Thomas R. Jackson Kristine Salmina Anda Huna Inna Inashkina Eriks Jankevics Una Riekstina Zane Kalnina Andrey Ivanov Paul A. Townsend Mark S. Cragg Jekaterina Erenpreisa 《Cell cycle (Georgetown, Tex.)》2013,12(3):430-431
Comment on: Wu R, et al. Clin Cancer Res 2011; 17:7359–72 相似文献
5.
Use of DNA fingerprinting for human population genetic studies 总被引:2,自引:0,他引:2
Vadim V. Kalnin Olga V. Kalnina Michael I. Prosniak Irina M. Khidiatova Elsa K. Khusnutdinova Khalim S. Raphicov Svetlana A. Limborska 《Molecular & general genetics : MGG》1995,247(4):488-493
DNA fingerprinting techniques have been used in population genetic studies on many different kinds of organisms. Here, we present new applications for multilocus DNA fingerprint probes in population studies and demonstrate the applicability of DNA fingerprinting to human population genetics, using M13 phage DNA as a probe. The new approach, which is based on a factor method of numerical coding of non-quantitative data (factor correspondence analysis-FCA), shows good agreement between population position, as indicated by the three principal factors, and ethnogenetic proximity. 相似文献
6.
W. O. van der Knaap Jacqueline F. N. van Leeuwen Helena Svitavská-Svobodová Irena A. Pidek Eliso Kvavadze Maia Chichinadze Thomas Giesecke Bogusław Michał Kaszewski Florencia Oberli Laimdota Kalniņa Heather S. Pardoe Willy Tinner Brigitta Ammann 《Vegetation History and Archaeobotany》2010,19(4):285-307
Annual PAR (pollen accumulation rates; grains cm?2 year?1) were studied with modified Tauber traps situated in ten regions, in Poland (Roztocze), the Czech Republic (two regions in Krkono?e, two in ?umava), Switzerland (4 regions in the Alps), and Georgia (Lagodekhi). The time-series are 10–16 years long, all ending in 2007. We calculated correlations between pollen data and climate. Pollen data are PAR summarized per region (4–7 traps selected per region) for each pollen type (9–14 per region) using log-transformed, detrended medians. Climate data are monthly temperature and precipitation measured at nearby stations, and their averages over all possible 2- to 6-month windows falling within the 20-month window ending with August, just prior to the yearly pollen-trap collection. Most PAR/climate relationships were found to differ both among pollen types and among regions, the latter probably due to differences among the study regions in the habitats of plant populations. Results shared by a number of regions can be summarized as follows. Summer warmth was found to enhance the following year’s PAR of Picea, Pinus non-cembra, Larix and Fagus. Cool summers, in contrast, increase the PAR of Abies, Alnus viridis and Gramineae in the following year, while wet summers promote PAR of Quercus and Gramineae. Wetness and warmth in general were found to enhance PAR of Salix. Precipitation was found to be more important for PAR of Alnus glutinosa-type than temperature. Weather did not have an impact on the PAR of Gramineae, and possibly of Cyperaceae in the same year. Care is advised when extrapolating our results to PAR in pollen sequences, because there are large errors associated with PAR from sediments, due to the effects of taphonomy and sedimentation and high uncertainty in dating. In addition, in pollen sequences that have decadal to centennial rather than near-annual resolution, plant-interaction effects may easily out-weigh the weather signal. 相似文献
7.
Vita Rovite Ramona Petrovska Iveta Vaivade Ineta Kalnina Davids Fridmanis Linda Zaharenko Raitis Peculis Valdis Pirags Helgi B. Schioth Janis Klovins 《Molecular biology reports》2014,41(3):1491-1500
Melanocortin 4 receptor (MC4R) is an important regulator of food intake and number of studies report genetic variations influencing the risk of obesity. Here we explored the role of common genetic variation from MC4R locus comparing with SNPs from gene FTO locus, as well as the frequency and functionality of rare MC4R mutations in cohort of 380 severely obese individuals (BMI > 39 kg/m2) and 380 lean subjects from the Genome Database of Latvian Population (LGDB). We found correlation for two SNPs—rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals. We sequenced the whole gene MC4R coding region in all study subjects and found five previously known heterozygous non-synonymous substitutions V103I, I121T, S127L, V166I and I251L. Expression in mammalian cells showed that the S127L, V166I and double V103I/S127L mutant receptors had significantly decreased quantity at the cell surface compared to the wild type MC4R. We carried out detailed functional analysis of V166I that demonstrated that, despite low abundance in plasma membrane, the V166I variant has lower EC50 value upon αMSH activation than the wild type receptor, while the level of AGRP inhibition was decreased, implying that V166I cause hyperactive satiety signalling. Overall, this study suggest that S127L may be the most frequent functional MC4R mutation leading to the severe obesity in general population and provides new insight into the functionality of population based variants of the MC4R. 相似文献
8.
E A Riabinskaia L B Kalnina 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1991,41(4):724-733
Spatial-motor asymmetry (SMA) of rats goal-directed running was studied in condition of numerous alternative choices in complex T-maze. In condition of free choices SMA in trained rats depended on reinforcement biological significance, volume and disposition scheme. In condition of non-free choices a change was possible of asymmetry of sequence of goal-directed motor acts adequate to situation, i.e. SMA regulation. Examples of the presence of properties of ego- and allocentric systems in SMA are given. The results of experiments testify to SMA dependence on the motivation of running, to rightfulness of SMA interpretation as behavioural tactics and to non-coming of SMA of goal-directed running to a simple rotation of animals. 相似文献
9.
Heather S. Pardoe Thomas Giesecke Willem O. van der Knaap Helena Svitavská-Svobodová Eliso V. Kvavadze Sampson Panajiotidis Achilles Gerasimidis Irena A. Pidek Marcelina Zimny Joanna Święta-Musznicka Małgorzata Latałowa Agnieszka M. Noryśkiewicz Elissaveta Bozilova Spassimir Tonkov Mariana V. Filipova-Marinova Jacqueline F. N. van Leeuwen Laimdota Kalniņa 《Vegetation History and Archaeobotany》2010,19(4):271-283
This paper compares pollen spectra derived from modified Tauber traps and moss samples from a selection of woodland types from Bulgaria, the Czech Republic, Georgia, Greece, Poland, Switzerland and Wales. The study examines the representation of individual taxa in the two sampling media and aims to ascertain the duration of pollen deposition captured by a moss. The latter aim was pursued through the calculation of dissimilarity indexes to assess how many years of pollen deposited in a pollen trap yield percentage values that are most similar to those obtained from the moss. The results are broadly scattered; the majority of moss samples being most similar to several years of pollen deposition in the adjacent trap. For a selection of samples, a comparison of the pollen accumulation rate in pollen traps with the pollen concentration in the moss per unit surface indicates that the entrapment and/or preservation of individual pollen types in the moss differ from that in the pollen trap. A comparison of the proportion of different taxa in the moss with the pollen spectrum of 2 years of pollen deposition in the trap also revealed large differences. There is a tendency for bisaccate grains such as Pinus and Picea to have a higher representation in moss than in traps but there is considerable regional variation. The results indicate that pollen proportions from moss samples often represent the pollen deposition of one area over several years. However, bisaccate pollen grains tend to be over-represented in moss samples compared to both pollen traps and, potentially, lake sediments. 相似文献
10.
Pollen‐based quantitative reconstructions of Holocene regional vegetation cover (plant‐functional types and land‐cover types) in Europe suitable for climate modelling
下载免费PDF全文
![点击此处可从《Global Change Biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A.‐K. Trondman M.‐J. Gaillard F. Mazier S. Sugita R. Fyfe A. B. Nielsen C. Twiddle P. Barratt H. J. B. Birks A. E. Bjune L. Björkman A. Broström C. Caseldine R. David J. Dodson W. Dörfler E. Fischer B. van Geel T. Giesecke T. Hultberg L. Kalnina M. Kangur P. van der Knaap T. Koff P. Kuneš P. Lagerås M. Latałowa J. Lechterbeck C. Leroyer M. Leydet M. Lindbladh L. Marquer F. J. G. Mitchell B. V. Odgaard S. M. Peglar T. Persson A. Poska M. Rösch H. Seppä S. Veski L. Wick 《Global Change Biology》2015,21(2):676-697