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Detecting non-neutral heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence 总被引:11,自引:4,他引:7
Natural selection, in the form of balancing selection or selective sweeps,
can result in a decoupling of the amounts of molecular polymorphism and
divergence. Thus natural selection can cause some areas of DNA sequence to
have greater silent polymorphism, relative to divergence between species,
than other areas. It would be useful to have a statistical test for
heterogeneity in the polymorphism to divergence ratio across a region of
DNA sequence, one that could identify heterogeneity greater than that
expected from the neutral processes of mutation, drift, and recombination.
The only currently available test requires that a region be arbitrarily
divided into sections that are compared with each other, and the
subjectivity of this division could be problematic. Here a test is proposed
in which runs of polymorphic and fixed sites are counted, where a "run" is
a set of one or more sites of one type preceded and followed by the other
type. The number of runs is smaller than otherwise expected if
polymorphisms are clumped together. By simulating neutral evolution and
comparing the observed number of runs to the simulations, a statistical
test is possible which does not require any a priori decisions about
subdivision.
相似文献
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Jordan Bai Muhammad Farid Abdul-Rahman Anne Rifkin-Graboi Yap-Seng Chong Kenneth Kwek Seang-Mei Saw Keith M. Godfrey Peter D. Gluckman Marielle V. Fortier Michael J. Meaney Anqi Qiu 《PloS one》2012,7(10)
We studied a sample of 75 Chinese, 73 Malay, and 29 Indian healthy neonates taking part in a cohort study to examine potential differences in neonatal brain morphology and white matter microstructure as a function of ethnicity using both structural T2-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). We first examined the differences in global size and morphology of the brain among the three groups. We then constructed the T2-weighted MRI and DTI atlases and employed voxel-based analysis to investigate ethnic differences in morphological shape of the brain from the T2-weighted MRI, and white matter microstructure measured by fractional anisotropy derived from DTI. Compared with Malay neonates, the brains of Indian neonates’ tended to be more elongated in anterior and posterior axis relative to the superior-inferior axis of the brain even though the total brain volume was similar among the three groups. Although most anatomical regions of the brain were similar among Chinese, Malay, and Indian neonates, there were anatomical variations in the spinal-cerebellar and cortical-striatal-thalamic neural circuits among the three populations. The population-related brain regions highlighted in our study are key anatomical substrates associated with sensorimotor functions. 相似文献
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Figs have been regarded as keystone plant resources that support diverse tropical vertebrate frugivore communities. Planting or conserving large fig trees, such as stranglers, have therefore been proposed for enhancing urban biodiversity. We compared the diversity and community structure of bird assemblages on strangler figs with non‐fig urban trees as well as between the fruiting and non‐fruiting fig trees in an urban setting in Singapore. The total bird abundance across all the fig trees when in fruit was 4.5‐fold higher than on non‐fig trees and 3.5‐fold higher than when the same fig trees were not fruiting, but only attracted two more species. On individual trees, after accounting for the presence of mistletoes, tree height, the area covered by buildings, road lane density, and the distance to natural vegetation, mean diversity was not different between non‐fig trees and fig trees when they were not in fruit. On the other hand, when fruiting, each fig tree on average had 1.4 more species, 3 more counts of non‐native birds, and 1.6 more counts of insectivorous birds than when not fruiting. There was significant compositional turnover between non‐fig trees and non‐fruiting fig trees, while community dispersion was significantly lower among fig trees in fruit. Our results demonstrate that fig trees provide fruit and non‐fruit resources for birds in an urban landscape but do not necessarily support more diverse total bird assemblages than non‐fig trees. Instead, bird communities on fruiting urban figs would be highly homogeneous and dominated by a few species. Abstract in Malay is available with online material. 相似文献
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Janine JH Oosterhof G Jolanda Elving Ietse Stokroos Arie van nieuw Amerongen Henny C van der Mei Henk J Busscher 《Biofouling》2013,29(6):347-353
The integrity of biofilms on voice prostheses used to rehabilitate speech in laryngectomized patients causes unwanted increases in airflow resistance, impeding speech. Biofilm integrity is ensured by extracellular polymeric substances (EPS). This study aimed to determine whether synthetic salivary peptides or mucolytics, including N-acetylcysteine and ascorbic acid, influence the integrity of voice prosthetic biofilms. Biofilms were grown on voice prostheses in an artificial throat model and exposed to synthetic salivary peptides, mucolytics and two different antiseptics (chlorhexidine and Triclosan). Synthetic salivary peptides did not reduce the air flow resistance of voice prostheses after biofilm formation. Although both chlorhexidine and Triclosan reduced microbial numbers on the prostheses, only the Triclosan-containing positive control reduced the air flow resistance. Unlike ascorbic acid, the mucolytic N-acetylcysteine removed most EPS from the biofilms and induced a decrease in air flow resistance. 相似文献
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