A dimeric chromanone and a phthalide: Metabolites from the seagrass-derived fungus Bipolaris sp. PSU-ES64

Two new metabolites, a dimeric chromanone, bipolarinone (1), and a phthalide, bipolarilide (2), as well as eight known compounds have been isolated from the seagrass-derived fungus Bipolaris sp. PSU-ES64. The structures were elucidated by analysis of spectroscopic data. The absolute configuration of 1 was determined by circular dichroism spectroscopy, Mosher's method, and NOEDIFF data. The antioxidant and antimicrobial activities of the isolated compounds were examined.     

Tricycloalternarene derivatives from the endophytic fungus Guignardia bidwellii PSU-G11

Four new tricycloalternarene derivatives, guignarenones A–D (1–4), along with known (6S,9R)-vomifoliol were isolated from the endophytic fungus Guignardia bidwellii PSU-G11. Their structures were determined on the basis of spectroscopic data. The absolute configurations in 1 were assigned using a combination of the modified Mosher's method and NOEDIFF data. Compound 1 displayed mild cytotoxic activity against oral cavity cancer and African green monkey kidney fibroblast (Vero) cell lines.