Effect of antenatal and postnatal hypoxia on the central nervous system and its correction with peptide hormones

Ante- and postnatal acute hypoxia significantly aggravated the postnatal development. The posthypoxic behaviour patterns included hyperactivity and training ability inhibition typical for the attention deficit syndrome. A preventive injection of peptide constellation significantly improved the posthypoxic postnatal development and abolished the most of the negative modifications of behavioural patterns.     

Individual features of rat behavior: manifestations of anxiety

Motor agitation developing in some white rats during painful stimulation of other individual decreases under the action of phenasepam (the most effective drug used in clinic in cases of neurotic alarm). This effect is accompanied by strengthening of tendency to reside in closed space. After phenasepam injection, increased not goal-directed motor activity developing against the background of reduced alimentary reactions also decreases in a part of grey rats selected by their ability to extrapolate, while their alimentary behaviour intensifies. Thus, initial peculiarities of behaviour i.e. enhanced motor activity not directed to fulfillment of the above forms of inborn behaviour (residing in closed space and eating) may be considered as a manifestation of anxiety. In this case, these forms of behaviour have a defensive function.     

Acute antenatal hypoxia on different stages of embryogenesis changes the offspring behavior patterns and biogenic amine levels

The effects of acute hypobaric hypoxia on the stages of progestation or beginning of organogenesis on biogenic amines levels in brain stem and cerebral cortex of their mature offspring as well as on their behavior, were investigated. It was shown that acute hypoxia applied in the period of embryonic organogenesis resulted in severe delayed changes in offspring spontaneous behavior and led to marked changes of biogenic amine levels, particularly expressed for dopaminergic system. Females subjected to antenatal hypoxia happened to be more sensitive to its influences than males.     

Comparison of the neutron- and gamma-radiation-induced transformations of 2-deoxy-D-ribose in aqueous solutions

Effectiveness of neutron radiation (1 MeV) was nearly twice as low as that of electrons and gamma-quanta with regard to the formation of products of radiolysis of 2-deoxy-D-ribose in aqueous solutions. A change in the dose-rate of sparsely ionizing radiation by the order of 5-6, and variation in the concentration of 2-deoxy-D-ribose from 1 to 5 mM did not substantially influence the G products of radiolysis.     

Comparative investigation of the delayed effects of prenatal hypoxia in the period of progestation and organogenesis

The aim of the present study was to compare the survival, physical development and spontaneous behavior of rat pups born from white rats subjected to acute hypobaric hypoxia on the 3rd-5th days of gestation (progestation) period or on the 9-10th day of gestation (period of early organogenesis). It was shown that the delayed effects of progestation hypoxia were less expressed than those following acute hypoxia modeled in the early organogenesis. In latter case, hypoxia led to the increased mortality among rat pups of both sexes while hypoxia-induced delay in physical development and changes in spontaneous behavior and anxiety level were registered up to the 57th day of postnatal period.