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1.
C. Sanderson 《BMJ (Clinical research ed.)》1974,1(5901):245-246
2.
Michael W. Shiflett Kristy L. Gould Tom V. Smulders Timothy J. DeVoogd 《Developmental neurobiology》2002,51(3):215-222
The hippocampal formation (HF) of food‐storing birds is larger than non‐storing species, and the size of the HF in food‐storing Black‐Capped Chickadees (Poecile atricapillus) varies seasonally. We examined whether the volume of the septum, a medial forebrain structure that shares reciprocal connections with the HF, demonstrates the same species and seasonal variation as has been shown in the HF. We compared septum volume in three parid species; non‐storing Blue Tits (Parus caeruleus) and Great Tits (Parus major), and food‐storing Black‐Capped Chickadees. We found the relative septum volume to be larger in chickadees than in the non‐storing species. We also compared septum and nucleus of the diagonal band (NDB) volume of Black‐Capped Chickadees at different times of the year. We found that the relative septum volume varies seasonally in food‐storing birds. The volume of the NDB does not vary seasonally. Due to the observed species and seasonal variation, the septum, like the hippocampal formation of food‐storing birds, may be specialized for some aspects of food‐storing and spatial memory. © 2002 Wiley Periodicals, Inc. J Neurobiol 51: 215–222, 2002 相似文献
3.
Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation 总被引:3,自引:0,他引:3
The effect of prior incubation with [3H]thymidine on survival and mutagenesis after X-irradiation of human lymphocytes was studied by incubating lymphocytes with 0.001-1.0 mu Ci/ml [3H]thymidine for 6 h at 37 degrees C and then irradiating with 150 or 300 rad. Survival was measured using lymphocyte cloning and mutagenesis was measured using 6-thioguanine selection to detect clones mutated at the hypoxanthine phosphoribosyltransferase locus. [3H]Thymidine alone had no effect on survival or mutagenesis and X-radiation alone produced the expected decrease in survival and increase in mutations. [3H]Thymidine prior to X-radiation had no effect on lethality of X-radiation but at concentrations of 0.1 and 1.0 mu Ci/ml produced a significant decrease in the number of mutations induced after both 150 and 300 rad. The results suggest that ionizing radiation, produced by disintegration of 3H, reduces the mutagenic effect of a subsequent exposure to ionizing radiation by induction of a system which prevents or repairs a restricted class of radiation damage. 相似文献
4.
5.
Summary Observations on the inhibition of root elongation and cell division in Allium cepa showed that the toxic effects of scandium and aluminium were very similar. Tracer uptake studies using 46Sc indicated that the rate of uptake in the apical 3.0 mm of the axis was more rapid than elsewhere in the root and proceeded in two distinct phases; Phase 1, probably superficial adsorption, was characterised by a rapid initial rate which was little affected by low temperature, the rate of Phase 2 was slower but remained constant for 24 hours and was highly dependent on temperature.Autoradiographs from roots treated for 30 min with 46Sc showed that most of the isotope in the root tip was concentrated in a peripheral belt corresponding with the mucigel layer of the root cap and it is suggested that this is the site of Phase 1 adsorption. The underlying root cap and epidermal cells retained little scandium but interior to them some isotope was associated with dividing cells; this increased steadily over 6 hour to an estimated concentration of 30 mM, and possibly represents Phase 2 uptake. Differentiation and secondary wall formation in the cortex restricted the rate of radial penetration of scandium. The primary endodermis restricted the entry of scandium into the stele at a very early stage in its development, which leads to the conclusion that migration of the ion across the root is primarily in the free space.Scandium enters the dividing cells in advance of observable effects on cell division, a situation compatible with the direct involvement of this ion in the inhibition of the mitotic cycle. Suggestions are made on the mechanisms by which polyvalent cations might disturb cell division and extension. 相似文献
6.
B lymphocytes express and lose syndecan at specific stages of differentiation. 总被引:21,自引:2,他引:19 下载免费PDF全文
Lymphopoietic cells require interactions with bone marrow stroma for normal maturation and show changes in adhesion to matrix during their differentiation. Syndecan, a heparan sulfate-rich integral membrane proteoglycan, functions as a matrix receptor by binding cells to interstitial collagens, fibronectin, and thrombospondin. Therefore, we asked whether syndecan was present on the surface of lymphopoietic cells. In bone marrow, we find syndecan only on precursor B cells. Expression changes with pre-B cell maturation in the marrow and with B-lymphocyte differentiation to plasma cells in interstitial matrices. Syndecan on B cell precursors is more heterogeneous and slightly larger than on plasma cells. Syndecan 1) is lost immediately before maturation and release of B lymphocytes into the circulation, 2) is absent on circulating and peripheral B lymphocytes, and 3) is reexpressed upon their differentiation into immobilized plasma cells. Thus, syndecan is expressed only when and where B lymphocytes associate with extracellular matrix. These results indicate that B cells differentiating in vivo alter their matrix receptor expression and suggest a role for syndecan in B cell stage-specific adhesion. 相似文献
7.
8.
Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding. 总被引:8,自引:1,他引:7 下载免费PDF全文
D G Brown M R Sanderson J V Skelly T C Jenkins T Brown E Garman D I Stuart S Neidle 《The EMBO journal》1990,9(4):1329-1334
The three-dimensional structure of a complex between the dodecanucleotide d(CGCGAATTCGCG) and the anti-trypanocidal drug berenil, has been determined to a resolution of 2.5 A. The structure has been solved by molecular replacement and refined to an R factor of 0.177. A total of 49 water molecules have been located. The drug is bound at the 5'-AAT-3' region of the oligonucleotide. At one end of the drug the amidinium group is in hydrogen-bonded contact with N3 of the adenine base complementary to the thymine of the AAT. The other amidinium group does not make direct interactions with the DNA. Instead, a water molecule mediates between them. This is in hydrogen-bonded contact with an amidinium nitrogen atom, N3 of the 5' end adenine base and the ring oxygen atom of an adjacent deoxyribose. Molecular mechanics calculations have been performed on this complex, with the drug at various positions along the sequence. These show that the observed position is only 0.8 kcal/mol higher in energy than the best position. It is suggested that there is a broad energy well in the AATT region for this drug, and that water molecules as well as the neighbouring sequence, will determine precise positioning. More general aspects of minor groove binding are discussed. 相似文献
9.
S. Laurie Sanderson Catherine R. Chesnutt Phillip S. Lobel 《Environmental Biology of Fishes》1996,46(4):365-373
Synopsis We have quantitatively analyzed a videotape of Seriola dumerili (Carangidae) displaying ram suspension-feeding behavior and ram ventilation in the field. This is the first report of facultative suspension feeding by a piscivorous carangid. The intraoral morphology of S. dumerili is not typical of ram suspension-feeding fishes in that closely-spaced, long gill rakers are lacking. While the mechanism of particle retention is not known for any ram suspension-feeding fish species, scanning electron microscopy revealed denticles on the branchial surfaces of S. dumerili that could play a role in particle entrapment. 相似文献
10.
Recent advances in computer technology have promoted the design and use of detailed, computer-based models for biological systems. For many non-biological systems, the complexity of such simulations may be considered inappropriate and unwieldy, but in biological systems, and more specifically in animal cell culture, this level of complexity simply mimics what is only beginning to be understood about metabolic processs. With this in mind, we contend that complex, structured models are vital tools in the investigation of fundamental biological processes. An example of such a simulation, which describes the commercial production of therapeutic proteins by animal cell cultures, is considered. 相似文献