排序方式: 共有3条查询结果,搜索用时 0 毫秒
1
1.
Kraskovskaya N. A. Erofeev A. I. Grishina E. D. Pushkareva S. A. Gerasimov E. I. Vlasova O. L. Bezprozvanny I. B. 《Journal of Evolutionary Biochemistry and Physiology》2021,57(6):1449-1460
Journal of Evolutionary Biochemistry and Physiology - Huntington’s disease is a hereditary, incurable, neurodegenerative disease characterized by movement disorders—progressive choreic... 相似文献
2.
Manon Callens Nina Kraskovskaya Kristina Derevtsova Wim Annaert Geert Bultynck Ilya Bezprozvanny Tim Vervliet 《Biochimica et Biophysica Acta (BBA)/Molecular Cell Research》2021,1868(6):118997
The family of B-cell lymphoma-2 (Bcl-2) proteins exerts key functions in cellular health. Bcl-2 primarily acts in mitochondria where it controls the initiation of apoptosis. However, during the last decades, it has become clear that this family of proteins is also involved in controlling intracellular Ca2+ signaling, a critical process for the function of most cell types, including neurons. Several anti- and pro-apoptotic Bcl-2 family members are expressed in neurons and impact neuronal function. Importantly, expression levels of neuronal Bcl-2 proteins are affected by age. In this review, we focus on the emerging roles of Bcl-2 proteins in neuronal cells. Specifically, we discuss how their dysregulation contributes to the onset, development, and progression of neurodegeneration in the context of Alzheimer's disease (AD). Aberrant Ca2+ signaling plays an important role in the pathogenesis of AD, and we propose that dysregulation of the Bcl-2-Ca2+ signaling axis may contribute to the progression of AD and that herein, Bcl-2 may constitute a potential therapeutic target for the treatment of AD. 相似文献
3.
Biochemistry (Moscow) - Huntington’s disease (HD) is a neurodegenerative, dominantly inherited genetic disease caused by expansion of the polyglutamine tract in the huntingtin gene. At the... 相似文献
1