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Azusa Tanimoto Shinji Takeuchi Hiroshi Kotani Kaname Yamashita Tadaaki Yamada Koushiro Ohtsubo Hiromichi Ebi Hiroko Ikeda Seiji Yano 《BMC pulmonary medicine》2018,18(1):193
Background
Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresectable PCS.Case presentation
A 65-year-old man who was diagnosed with PCS was treated by surgical removal of the primary lung lesion, followed by six cycles of adjuvant chemotherapy with cisplatin plus irinotecan. Following the chemotherapy, he experienced a relapse with brain metastasis, which induced the rapid onset of left leg paralysis. Radical surgical resection and stereotactic radiosurgery to the resection cavity were performed. However, meningeal dissemination and new lung metastases occurred after a year and half. To control these multiple metastatic lesions, the patient was treated with the multiple kinase inhibitor pazopanib. No change was observed in the meningeal dissemination, while the metastatic lung lesions were prominently reduced in size following treatment with pazopanib. Consequently, the patient showed a partial response to pazopanib treatment, although the dose of pazopanib was reduced by half as a result of thrombocytopenia.Conclusion
This is the first report of metastatic PCS showing an evident therapeutic response to tumor-targeted therapy. We suggest that pazopanib may be a therapeutic option for patients with metastatic PCS.2.
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In apple fruit, active ATP-dependent microsomal Ca2$ uptakeand respiration-dependent mitochondrial Ca2$ uptake were observed. The mitochondrial Ca2$ uptake was depressed by the calmodulinantagonists chlorpromazine hydrochloride (CPZ) and N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamidehydrochloride (W-7). The Ca2$-ATPase from apple mitochondriawas also inhibited by CPZ or W-7. The apparent Km value forCa2$ in mitochondrial Ca2$ uptake (Km=0.35 mM) was similar tothat of mitochondrial Ca2$-ATPase (Km=0.32 mM). The inhibitoryeffect of W-7 on the activity of the mitochondrial Ca2$ uptakewas closely correlated with the inhibition by W-7 of mitochondrialCa2$-ATPase (r=0.996). These findings indicate that the mitochondrialuptake of Ca2$ in apple fruit depends on the calmodulin-mediatedactivation of Ca2$-ATPase. The microsomal Ca2$ uptake was depressed by CPZ, suggestingthat the microsomal Ca2$ uptake may also be modulated by calmodulin.
1 Contribution No. C-72, Fruit Tree Research Station. (Received June 7, 1982; Accepted October 19, 1982) 相似文献
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