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Pagán OR Baker D Deats S Montgomery E Tenaglia M Randolph C Kotturu D Tallarida C Bach D Wilk G Rawls S Raffa RB 《The International journal of developmental biology》2012,56(1-3):193-196
Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic com-pounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide is a specific anti-cocaine agent in this experimental organism. 相似文献
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Alluri Kiran Nair Krishna Pillay Madhavan Kotturu Sandeep Kumar Ghosh Sudip 《Biological trace element research》2020,194(2):360-367
Biological Trace Element Research - Bone is a passive storage organ for zinc, which contains about 30% of the total body zinc. However, during extreme zinc deficiency, only a small fraction of zinc... 相似文献
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