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1.
L K Riago A M Nurk A Ia Korneev L Kh Allikmets 《Biulleten' eksperimental'no? biologii i meditsiny》1982,94(11):58-59
(+/-) Fenibut beta-phenyl-GABA) was not able to displace 3H-GABA in Na+ independent GABA binding (IC50 greater than 250 microM). Nevertheless, (+/-) fenibut and (+/-) baclofen effectively displaced 3H-GABA in Ca2+ dependent GABA binding in the presence of 50 microM (+) bicuculline. (+/-) Fenibut was less potent in this respect. It is suggested that fenibut may act via bicuculline-insensitive GABA receptors. 相似文献
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Flow cytometry analysis of DNA degradation in thymocytes of gamma-irradiated or hydrocortisone treated rats 总被引:1,自引:0,他引:1
V A Pechatnikov V N Afanasyev B A Korol V N Korneev S R Rochev YuAUmansky 《General physiology and biophysics》1986,5(3):273-284
The pattern of DNA degradation in thymocytes of irradiated or hydrocortisone-treated rats has been studied by means of flow cytometry of the cells, treated with probes specifically bound to the AT or GC-pairs of DNA. It has been shown that the death of thymocytes is accompanied by a decrease in their DNA content. The main features of the occurrence and accumulation of cells with a DNA content less than the normal diploid level correspond with those of internucleosomal DNA fragmentation: such cells appear after a 1 hour lag-period, their accumulation is prevented by cycloheximide injection and is lower at 300 Gy than at doses of 10 to 30 Gy. At the same time, no increase in permeability of the cell membrane to ethidium bromide was observed up to the sixth hour after irradiation. Most of the thymocytes dying under the action of irradiation or hydrocortisone are in the G0 or G1 phases of the cell cycle. The method used allows detection of the cells with cleaved but not removed DNA. 相似文献
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Porshakov A. M. Korneev M. G. Chumachkova E. A. Chau Nguyen Van Toan Thinh Van Cuong Vo Viet 《Entomological Review》2021,101(9):1287-1292
Entomological Review - Analysis of the literature data has shown that the present day flea fauna of mammals in Vietnam is represented by 50 flea species. In 2019–2020, we surveyed seven... 相似文献
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Mitkin N. A. Ustiugova A. S. Uvarova A. N. Rumyantsev K. A. Korneev K. V. Pavshintsev V. V. 《Molecular Biology》2021,55(6):910-918
Molecular Biology - Expression levels of matrix metalloproteinases, in particular MT1-MMP, are elevated in pancreatic cancer (PC) cells, and this is associated with increased tumor proliferation,... 相似文献
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O. S. Korovina D. V. Korneev G. M. Levagina M. P. Bogryantseva V. I. Masycheva 《Applied Biochemistry and Microbiology》2013,49(7):660-663
A molecular construct of a spherical shape containing double-stranded RNA (dsRNA) in the center, coated by a spermidine-polyglucine coat, and carrying recombinant deltaferon—an analogue of recombinant interferon-gamma—has been designed. It is shown that deltaferon in this construct retains its specific activity at a level of 9 × 104 U/mg. It was found that deltaferon and dsRNA in the construct were characterized by enhanced resistance to proteases (trypsin) and nucleases (E. coli ribonuclease) as compared to free deltaferon and dsRNA. An increased resistance of deltaferon in the construct to environmental temperature during storage was also demonstrated. 相似文献
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Davydov S. G. Dolgov A. N. Karpov M. A. Korneev A. V. Nikishin D. V. Pshenichniy A. A. Yakubov R. Kh. 《Plasma Physics Reports》2019,45(11):1071-1074
Plasma Physics Reports - Switching of a short vacuum gap with an auxiliary discharge over the surface of a dielectric has been studied via high-speed recording of images of discharge plasma... 相似文献
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