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A V Maksimenko E L Terent'eva O Iu Konovalova V P Torchilin 《Ukrainski? biokhimicheski? zhurnal》1988,60(2):20-25
Chondroitin sulphate forms noncovalent electrostatic biocatalyst-glycosaminoglycan complexes in the solutions of enzymes. Chondroitin sulphate also interacts with enzymes developing complexes after carbodiimide activation of its carboxylic groups. Relatively low-molecular weight of biocatalysts (chymotrypsin, superoxide dismutase) forms stable noncovalent conjugates with the additional interaction as compared with electrostatic complexes. High-molecular weight of enzymes (acid phosphatase) develops covalent conjugates. Chondroitin sulphate is proposed for covalent binding of large proteins and multi-enzymatic complexes to obtain their stabilized derivatives for medical application. 相似文献
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It has been found that superoxide radicals formed at autooxidation of Fe(II) ions or of their complexes with EDTA in the presence of NAD.H cause reduction of met-Hb into deoxy or oxy-form. Under the effect of hydroxyl radicals generated in the ultrasonic field in the presence of NADH reduction of met-Hb into the ferro-form (carboxy-Hb) was observed in Co atmosphere and not in O2 atmosphere. It was induced by a high oxidation rate of oxy-Hb by hydroxyl radicals into met-Hb as compared to carboxy-Hb. Reduction of met-Hb was shown to be accompanied with the formation of NAD+. The role of NAD. radicals in the reduction of met-Hb which acts as an antioxidant in respect to organic free radicals was discussed. 相似文献
5.
Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance. 总被引:3,自引:0,他引:3
N P Konovalova S A Goncharova L M Volkova T A Rajewskaya L T Eremenko A M Korolev 《Nitric oxide》2003,8(1):59-64
The potentiality to increase the chemotherapeutic effectiveness of some cytostatics in low, subtherapeutic doses in combination with nitric oxide (NO) donor has been shown. This type of combined therapy results in significant increase in life span and number of survivors among mice bearing leukemias P388 and L-1210. A similar effect was observed for intracerebral leukemia P388 transplantation. In this case the life span of mice treated with cyclophosphamide and NO donor increased by three times in comparison to therapy with cyclophosphamide alone. The coinjection of nitric oxide donor and cytostatics improved the antimetastatic activity of the cytostatics: the index of melanoma B16 metastasis inhibition at the cyclophosphamide monotherapy is 50%; on addition of NO donor the index is over 80%. Comparative studies of NO donor (organic nitrate) and a similar compound in which ONO(2) moieties were replaced by OH groups demonstrated that the presence of NO(2) is required for adjuvant activity of compounds and confirmed that nitric oxide modifies the antitumor effects of cytostatics. It is shown also that nitric oxide donor retards the development of drug resistance to cyclophosphamide. 相似文献
6.
K.?B.?ShumaevEmail author V.?Z.?Lankin G.?G.?Konovalova A.?K.?Tikhaze E.?K.?Ruuge 《Biophysics》2017,62(2):172-176
The interaction of superoxide radical anion (O2 ??) with active dicarbonyls (methylglyoxal, glyoxal, and malonic dialdehyde) was studied. It was demonstrated that glyoxal and methylglyoxal inhibited superoxide-dependent accumulation of formazan; however, malonic dialdehyde stimulated this process. The formation of O2 ?? in these experiments occurred during the decomposition of the SOTS-1 azo initiator. On the other hand, all of the studied dicarbonyls in this system of O2 ?? generation competed for superoxide with the TIR ON spin trap. These compounds also inhibited luminal-dependent chemiluminescence during the AIBN azo initiator-induced peroxidation of liposomes from the egg phosphatidylcholine. A mechanism for the antiradical and antioxidant effects of the studied dicarbonyls, assuming the production of free radical intermediates in their reactions with O2 ?? or its protonated form, is proposed. 相似文献
7.
It is established that the activity of malate dehydrogenase and glucose-6-phosphate dehydrogenase in rats aged 1,3 and 12 months lowers under fasting and on high-fatty diet and in old animals (24 months) on a high-fatty diet only the glucose-6-phosphate dehydrogenase activity decreases. When rats after fasting are put on high-carbohydrate diet the activity value of the mentioned enzymes has already returned to the initial level after 12 hours in rats aged 1 and 12 months and in rats aged 3 months it exceeds that activity in intact rats. The rise in the activity of the determined enzymes is completely blocked by the preliminary administration of actinomycin D. The isocitrate dehydrogenase activity remains unchanged under conditions of maintaining animals on different diets. 相似文献
8.
Konovalova L. N. Strelnikova S. R. Zlobin N. E. Kharchenko P. N. Komakhin R. A. 《Applied Biochemistry and Microbiology》2021,57(7):800-807
Applied Biochemistry and Microbiology - The production of mesophilic protoplasts of potato (Solanum tuberosum L.) for transient gene expression is a required technological stage in the testing of... 相似文献
9.
The results of studying the postfire successional change of light-coniferous and small-leaved forests of the prienisey part of the East Sayan Region are presented based on the landscape ecology approach. A general diagram of the direction and rate of succession changes has been made and analyzed considering the pyrogenous factor. 相似文献
10.
Orthologous gene-expression profiling in multi-species models: search for candidate genes 总被引:2,自引:0,他引:2
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Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes. 相似文献