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1.
O A Bogoslovskaia L V Andreev E B Burlakova N N Glushchenko V F Koniukhov 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1984,(12):65-68
Experiments on E. coli used as a model have revealed that fatty-acid composition is one of the characteristics which determine the viability of bacteria in the air. The viability of microbial cells in the air has been shown to increase with the increase of the pool of cyclopropane acids and the palmitic acid/palmitoleic acid ratio in the cells, irrespective of their genotype and the phase of their growth. 相似文献
2.
We studied the rate and duration of the growth of G1 and G3 hairs in mice homozygous for angora-Y mutant gene (goY). The follicular diameter of G3 hairs and the growth rate of G1 and G3 hairs in goY/goY mice do not differ from normal. However, the duration of growth period of all four studied types of hairs in goY/goY mice is longer than in the normal phenotype. Growth of the guard hairs G1 and G3 in mutants continues longer than in the normal phenotype by 7 and 3 days, respectively. For other hair types G1 and G3 (awl, auchene, zigzag) the duration of the growth period is approximately 3 days longer than in the control. As a result in goY/goY mice guard hairs G1 and G3 which have completed growth are 2 and 1.5 times longer than in +/+ mice. Other types of G1 hairs in mutants are longer by 50% and G3 hairs by 30% than in the wild type. 相似文献
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4.
The site of action of the goY mutant gene was determined in the aggregation chimaeras C57BL-goY/goY----DBA (+/+). Chimerism was detected by mosaicism of coat pigmentation and electrophoretic pattern of glucose phosphate isomerase. In 28-day-old chimaeras the regions of light-brown coat alternated black coat, stripes of short hairs alternated those of long hairs. These stripes of different length and width extended from spine in lateral-ventral direction. The hairs plucked from long hairs stripes had a similar length that those of goY/goY mice of same age, but the hairs plucked from short hair stripes corresponded to the hair length of +/+ mice. These data show that the goY gene acts in epidermal cells of hair follicles and its expression is autonomous. It has been established that in double homozygotes goY/goYfzY/fzY both mutant genes are expressed: the considerable increase of hair length as compared to norm--the effect of the goY gene and curly coat--the effect of the fzY gene. In goY/goYfzY/fzY mice during the formation of G1 guard hairs the incomplete expression of the goY gene is observed that is due to the suppression of hair growth by the fzY mutant gene. The fzY gene does not suppress the growth of G2 hairs and therefore the full expression of the goY gene occurs in goY/goYfzY/fzY adult mice. 相似文献
5.
Sexually dimorphic characters have two-fold complexities in pattern formation as they have to get input from both somatic sex determination as well as the positional determining regulators. Sex comb development in Drosophila requires functions of the somatic sex-determining gene doublesex and the homeotic gene Sex combs reduced. Attempts have not been made to decipher the role of dsx in imparting sexually dimorphic expression of SCR and the differential function of sex-specific variants of dsx products in sex comb development. Our results in this study indicate that male-like pattern of SCR expression is independent of dsx function, and dsx F must be responsible for bringing about dimorphism in SCR expression, whereas dsx M function is required with Scr for the morphogenesis of sex comb. 相似文献
6.
B V Koniukhov 《Uspekhi sovremenno? biologii》1975,80(2):185-203
7.
Ibragimova MI Petukhov VIu Zheglov EP Koniukhov GV Nizamov RN 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2004,44(5):529-534
The effect of radiotoxin (RT) obtained from y-irradiated potato tubes on blood of sheep and mice has been investigated by using in vitro and ex vivo EPR. In experiments in vitro, the action of different preparations (RT, extract from unirradiated potato tubers, 1%-HCl or 30%-hydrogen peroxide) on sheep blood has been compared. It has been established that RT is an effective oxidant (like 1%-HCl) of haem iron that leads to an increase of the methemoglobin concentration. The specific peculiarity of RT effect on blood in vitro is an appearance of two well-resolved lines from methemoglobin belonging, probably, to different paramagnetic centers. The signal from nonspecific complexes of Fe3+ has been also observed. Ex vivo EPR spectra markedly differ from these obtained in experiments in vitro. An additional line with g approximately 2.005 and width 6 G in 30 minutes after intraperitoneal RT injection in the lethal dose (0.2 ml of preparation containing of 2 mg RT) has been revealed. Subsequent intoxication of mice is accompanied by the appearance of the signal from nitrosyl complexes in EPR spectra. These differences in experimental results of in vitro and ex vivo EPR can be explained by launch of compensatory adaptive response of organism on the action of highly toxic preparation. 相似文献
8.
Clonal analysis of parthenogenetic chimeric mouse embryos C57B1/6(PG)<-->BALB/c has shown that parthenogenetic cell clones C57BL/6 are present in the brain, liver, and kidneys of 14- and 18-day-old embryos. The content of the parthenogenetic component (PG) in these organs on day 18 was lower than on day 14, and, in some 18-day-old embryos, parthenogenetic cell clones were absent from the liver and/or kidneys. These data suggest that, during the embryogenesis of parthenogenetic chimeras, parthenogenetic cell clones of mostly endodermal and mesodermal origins were actively eliminated. Therefore, in such parthenogenetic adult chimeras, parthenogenetic clones of mostly ectodermal origins were preserved. In parthenogenetic chimeras CBA(PG)<-->BALB/c, parthenogenetic cell clones were actively eliminated at early embryonic stages, and, as a result, they were absent at the post-implantation stages. Hence, during development of parthenogenetic cell clones, the effects of genomic imprinting are expressed unequally in C57BL/6 and CBA mice. 相似文献
9.
Interspecies chimeras of mammals 总被引:1,自引:0,他引:1
B V Koniukhov 《Ontogenez》1985,16(3):242-246
Chimaeras between closely related and distant mammalian species were obtained during the last decade using the aggregation and injection methods. In the chimaeras between the closely related species Mus musculus--M. caroli, the cell clones of both parental species are equally represented; such chimaeras are fertile and their development does not differ from that of intraspecific chimaeras. But in the chimaeras between distant species mouse--rat or sheep--goat a selective predominance of cells with one genotype over those with another was noted. This leads to the total elimination of cell populations with one genotype, rat in particular in the mouse--rat chimaeras, or, possibly, to the sterility of the sheep--goat chimaeras. 相似文献
10.
Aggregation of mouse embryos produced 11 chimaeras Miwh/+C/C----+/+c/c and 8 chimaeras +/+C/C----+/+c/c (control). Chimaerism was detected by mosaicism of coat retinal pigment epithelium and by electrophoretic pattern of glucose phosphate isomerase. All chimaeras showed a common pattern of pigmented and unpigmented hair regions that alternated as stripes of different length and width and extended from spine in lateral-ventral direction. However, white coat color predominated in Miwh/+C/C----+/+c/c chimaeras due to a higher proportion of unpigmented zones as well as to weakening of hair color in pigmented areas. Besides, distal regions of limbs were always unpigmented in Miwh/+C/C----+/+c/c chimaeras and completely or partially pigmented in +/+C/C----+/+c/c chimaeras. Pigmented hair regions are often located on the ventral trunk surface where the Miwh/+ heterozygotes usually had an unpigmented spot. The examination of hairs, taken from the same regions of gray coloration, revealed the presence of pigmented, unpigmented and mosaic hairs. The proportion of unpigmented hairs was much higher in Miwh/+C/C----+/+c/c chimaeras than in +/+C/C----+/+c/c chimaeras. The data obtained indicate that a single Miwh gene dose reduced proliferative activity of melanoblasts which resulted in weakening of coat pigmentation. 相似文献