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The pharmacological activity of amiridine, a drug resynthesized at the Scientific Research Institute Khimtekhnologiya (Severodonetsk, Ukraine), was studied. It was found that amiridine is a moderately toxic compound and exerts marked analgesic effects on pain of different geneses. 相似文献
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Pous'kov A. N. Sharykina N. I. Pavlovskaya G. P. Kirichok L. M. Karatsuba T. A. 《Neurophysiology》2000,32(6):390-394
We studied the effects of treatments with adrenaline hydrochloride, obsidan (a -adrenoblocker), melipramine (an inhibitor of monoamine uptake by neurons), and reserpine (a sympatholytic drug) on tumor growth (Pliss' lymphosarcoma in rats) and on the antitumor activity of a novel cytostatic drug, chlofiden. We found that adrenaline and reserpine enhanced the antitumor effect of chlofiden. Isolated applications of adrenaline and melipramine exerted slight antitumor effects, while after reserpine treatment there was a trend toward stimulation of tumor growth. Under the conditions of the model used, obsidan demonstrated no noticeable antitumor activity and did not modify the antitumor effect of chlofiden. Possible mechanisms of the observed effects are discussed. 相似文献
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Ion channels that control fertility in mammalian spermatozoa 总被引:1,自引:0,他引:1
Navarro B Kirichok Y Chung JJ Clapham DE 《The International journal of developmental biology》2008,52(5-6):607-613
Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSlo3. Intracellular alkalinization activates both channels and induces hyperactivated motility. 相似文献
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Yu. V. Kirichok Ya. A. Boychuk M. V. Kopanitsa T. Sh. Tsintsadze N. A. Lozovaya O. A. Krishtal 《Neurophysiology》2000,32(1):12-16
The effects of a novel anti-hypertensive drug, mibefradil, on voltage-dependent currents in isolated thalamic and hippocampal
neurons, as well as on synaptic transmission in the hippocampus have been studied. Mibefradil exerted a potent inhibitory
action on low-threshold calcium currents in thalamic neurons (IC50=160 nM). In higher concentrations (1–20 μM), this drug blocked not only low-threshold calcium current but also voltage-dependent
sodium and delayed potassium currents in pyramidal hippocampal neurons. The amplitude of population action potentials in hippocampal
slices decreased by 55% in the presence of 20μM mibefradil. All of the effects of mibefradil were almost completely reversible.
In our experiments, the sensitivity of low-threshold calcium channels in thalamic neurons to mibefradil was higher than that
observed on other objects. The ability of mibefradil to block not only calcium currents but also other types of voltage-dependent
ion conductances in hippocampal neurons may be considered an essential factor that determines the specificity of the pharmacological
profile of this drug. 相似文献
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