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1.
The purpose of this study was to determine if the effect of visually targeted gripping on shoulder muscle activity was maintained with repeated exposures. Eleven healthy males had eight shoulder muscles monitored via surface electromyography while maintaining shoulder elevation at 90° in the scapular plane with and without a 30% grip force. Three non-gripping trials were followed by 15 gripping trials and another 3 non-gripping control trials. Gripping significantly decreased the activity of the anterior deltoid, trapezius, and latissimus dorsi over the exposure of 15 trials. Gripping also reduced variability in all muscles' activity. The changes in shoulder muscle activity are likely in response to forces being transferred through multi-articular muscles spanning from the forearm to the shoulder. Targeted gripping during shoulder elevation resulted in small but significant decreases in muscle activity and reduced variability which supports previous evidence for increased risk of upper extremity disorders in occupational settings.  相似文献   
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Leg power is an important component in assessing both performance-related and health-related fitness. The Lewis equation and nomogram have been used for years to estimate leg power. A recent evaluation of the Lewis equation and further research led to the development of the Sayers equation. This equation provides an estimate of peak leg power, which has greater relevance than average power. Our purpose was to provide a simple and effective nomogram for calculating peak leg power output. The Sayers equation was transformed to an alignment nomogram and evaluated for facility of use and accuracy. The resultant alignment nomogram is easy to use and generates values for peak leg power in the vertical jump, which are well within the precision of the regression equation (r > 0.9999, CV < 0.2%). Interobserver error was less than 0.3% with a correlation of 0.9999. The Keir nomogram provides a simple and effective representation of the Sayers equation for use in both performance-related and health-related fitness assessments.  相似文献   
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A mathematical model is proposed which systematically investigates complex calcium oscillations in pancreatic acinar cells. This model is based on calcium-induced calcium release via inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR) and includes calcium modulation of inositol (1,4,5) trisphosphate (IP3) levels through feedback regulation of degradation and production. In our model, the apical and the basal regions are separated by a region containing mitochondria, which is capable of restricting Ca2+ responses to the apical region. We were able to reproduce the observed oscillatory patterns, from baseline spikes to sinusoidal oscillations. The model predicts that calcium-dependent production and degradation of IP3 is a key mechanism for complex calcium oscillations in pancreatic acinar cells. A partial bifurcation analysis is performed which explores the dynamic behaviour of the model in both apical and basal regions.  相似文献   
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OBJECTIVE: To determine up to what age children remain at risk of developing a new renal scar from a urinary tract infection. DESIGN: Follow up study. Families of children who had normal ultrasound scans and scanning with dimercaptosuccinic acid (DMSA) after referral with a urinary tract infection when aged 3 (209) or 4 (220) were invited to bring the children for repeat scans 2-11 years later. A history of infections since the original scan was obtained for children not having a repeat scan. SETTING: Teaching hospital. SUBJECTS: Children from three health districts in whom a normal scan had been obtained at age 3-4 years in 1985-1992 because of a urinary tract infection. MAIN OUTCOME MEASURE: Frequency of new renal scars in each age group. RESULTS: In each group, about 97% of children either had repeat scanning (over 80%) or were confidently believed by their general practitioner or parent not to have had another urinary infection. The rate of further infections since the original scan was similar in the 3 and 4 year old groups (48/176 (27%)) and 55/179 (31%)). Few children in either group known to have had further urinary infections did not have repeat scanning (3/209 (1.4%) and 4/220 (1.8%)). In the 3 year old group, 2.4% (5/209) had one or more new kidney scars at repeat scanning (one sided 95% confidence interval up to 5.0%), whereas none of the 4 year olds did (one sided 95% confidence interval up to 1.4%). The children who developed scars were all aged under 3.4 years when scanned originally. CONCLUSIONS: Children with a urinary tract infection but unscarred kidneys after the third birthday have about a 1 in 40 risk of developing a scar subsequently, but after the fourth birthday the risk is either very low or zero. Thus the need for urinary surveillance is much reduced in a large number of children.  相似文献   
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The best method of assessing muscular force qualities during isoinertial stretch shorten cycle lower body movements remains a subject of much debate. This study had 2 purposes: Firstly, to calculate the interday reliability of peak force (PF) measurement and a variety of force-time measures, and, secondly, to compare the reliability of the 2 most common technologies for measuring force during loaded jump squats, the linear position transducer (PT), and the force plate (FP). Twenty-five male elite level rugby union players performed 3 rebound jump squats with a 40-kg external load on 2 occasions 1 week apart. Vertical ground reaction forces (GRFs) were directly measured via an FP, and force was differentiated from position data collected using a PT. From these data, a number of force-time variables were calculated for both the FP and PT. Intraclass correlation coefficient (ICC), coefficient of variation (CV), and percent change in the mean were used as measures of between-session reliability. Additionally, Pearson's product moment correlation coefficients were used to investigate intercorrelations between variables and technologies. Both FP and PT were found to be a reliable means of measuring PF (ICC = 0.88-0.96, CV = 2.3-4.8%), and the relationship between the 2 technologies was very high and high for days 1 and 2, respectively (r = 0.67-0.88). Force-time variables calculated from FP data tended to have greater relative and absolute consistency (ICC = 0.70-0.96, CV = 5.1-51.8%) than those calculated from differentiated PT data (ICC = 0.18-0.95, CV = 7.7-93.6%). Intercorrelations between variables ranged from trivial to practically perfect (r = 0.00-1.00). It was concluded that PF can be measured reliably with both FP and PT technologies, and these measurements are related. A number of force-time values can also be reliably calculated via the use of GRF data. Although some of these force-time variables can be reliably calculated using position data, variation of measurement is generally greater when using position data to calculate force.  相似文献   
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Neurochemical Research -  相似文献   
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Muscle specific maximal voluntary isometric contractions (MVIC) are commonly used to elicit reference amplitudes to normalize electromyographic signals (EMG). It has been questioned whether this is appropriate for normalizing EMG from dynamic contractions. This study compares EMG amplitude when shoulder muscle activity from dynamic contractions is normalized to isometric and isokinetic maximal excitation as well as a hybrid approach currently used in our laboratory. Anterior, middle and posterior deltoid, upper and lower trapezius, pectoralis major, latissimus dorsi and infraspinatus were monitored during (1) manually resisted MVICs, and (2) maximum voluntary dynamic concentric contractions (MVDC) on an isokinetic dynamometer. Dynamic contractions were performed (a) at 30°/s about the longitudinal, frontal and sagittal axes of the shoulder, and (b) during manual bi-rotation of a tilted wheel at 120°/s. EMG from the wheel task was normalized to the maximum excitation from (i) the muscle specific MVIC, (ii) from any MVIC (MVICALL), (iii) for any MVDC, (iv) from any exertion (maximum experimental excitation, MEE). Mean EMG from the wheel task was up to 45% greater when normalized to muscle specific isometric contractions (method i) than when normalized to MEE (method iv). Seventy-five percent of MEE’s occurred during MVDCs. This study presents an 20 useful and effective process for obtaining the greatest excitation from the shoulder muscles when normalizing dynamic efforts.  相似文献   
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