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Nitric oxide (NO) is a janus faced chemical messenger, which, in the recent years, has been the focus of neurobiologists for its involvement in neurodegenerative disorders in particular, Parkinson's disease (PD). Nitric oxide synthase, the key enzyme involved in NO production exists in three known isoforms. The neuronal and inducible isoforms have been implicated in the pathogenesis of PD. These enzymes are subject to complex expressional and functional regulation involving mRNA diversity, phosphorylation and protein interaction. In the recent years, mRNA diversity and polymorphisms have been identified in the NOS isoforms. Some of these genetic variations have been associated with PD, indicating an etiological role for the NOS genes. This review mainly focuses on the NOS genes - their differential regulation and genetic heterogeneity, highlighting their significance in the pathobiology of PD. 相似文献
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Kavya N. M. Adil Lateef Senthilkumar Palanisamy 《Plant Molecular Biology Reporter》2021,39(4):833-840
Plant Molecular Biology Reporter - Saponins are naturally occurring glycosides which are produced by various plant species with diverse biological properties. The surface-active properties of... 相似文献
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Choudhury Mitali Koduru Tejaswi Naidu Kumar Naveen Salimi Sasan Desai Kavya Prabhu Nagu Prakash Sritharan Manjula 《Biometals》2021,34(3):511-528
BioMetals - Iron-starved Mycobacterium tuberculosis utilises the carboxymycobactin-mycobactin siderophore machinery to acquire iron. These two siderophores have high affinity for ferric iron and... 相似文献
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Patrick Yusuf Lee Alice Raha Oishik Pillai Kavya Gupta Shubham Sethi Sonika Mukeshimana Felicite Gerard Lothaire Moghal Mohammad U. Saleh Sohag N. Smith Susan F. Morrell Mary J. Moss James 《Sleep and biological rhythms》2017,15(3):217-225
Sleep and Biological Rhythms - Sleep deprivation is common among university students, and has been associated with poor academic performance and physical dysfunction. However, current literature... 相似文献
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K. Madhumathi P.T. Sudheesh Kumar K.C. Kavya T. Furuike H. Tamura S.V. Nair R. Jayakumar 《International journal of biological macromolecules》2009,45(3):289-292
Biopolymers like chitin are widely investigated as scaffolds in bone tissue engineering. Its properties like biocompatibility, biodegradability, non-toxicity, wound healing ability, antibacterial activity, hemostatic property, etc., are widely known. However, these materials are not much bioactive. Addition of material like silica can improve the bioactivity and biocompatibility of chitin. In this work, chitin composite scaffolds containing nanosilica were prepared using chitin hydrogel and their bioactivity, swelling ability and cytotoxicity was analyzed in vitro. These scaffolds were found to be bioactive in simulated body fluid (SBF) and biocompatible when tested with MG 63 cell line. These results suggest that chitin/nanosilica composite scaffolds can be useful for bone tissue engineering applications. 相似文献