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Flekhter O. B. Karachurina L. T. Nigmatullina L. R. Sapozhnikova T. A. Baltina L. A. Zarudii F. S. Galin F. Z. Spirikhin L. V. Tolstikov G. A. Plyasunova O. A. Pokrovskii A. G. 《Russian Journal of Bioorganic Chemistry》2002,28(6):494-500
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. 相似文献
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O. B. Flekhter L. T. Karachurina V. V. Poroikov L. P. Nigmatullina L. A. Baltina F. S. Zarudii V. A. Davydova L. V. Spirikhin I. P. Baikova F. Z. Galin G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2000,26(3):192-200
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, andp-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin
esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor.
These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate
was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. 相似文献
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Flekhter OB Karachurina LT Nigmatullina LR Sapozhnikova TA Baltina LA Zarudiĭ FS Galin FZ Spirikhin LV Tolstikov GA Pliasunova OA 《Bioorganicheskaia khimiia》2002,28(6):543-550
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru. 相似文献
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Flekhter OB Karachurina LT Poroĭkov VV Nigmatullina LR Baltina LA Zarudiĭ FS Davydova VA Spirikhin LV Baĭkova IP Galin FZ Tolstikov GA 《Bioorganicheskaia khimiia》2000,26(3):215-223
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bis-hemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. 相似文献
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