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Normative adontometric data are presented on a sample of 100 adult Cercopithecus aethiops(51 male, 49 female). When correlation effects among the teeth were held constant through multivariate canonical analyses,
contributions of individual tooth loci to the male-female distance were found to be similar to those isolated by univariate
means. The present study fails to support Garn’s field theory of sex dimorphism. When these patterns of sexual dimorphism
were contrasted with those of three other conspecific groups, the anterior teeth were found to show greater intrapopulation
variation than the posterior teeth. This, together with the finding that Penrose’s shape distances between the groups were
greater for anterior than postcanine teeth, provides evidence in support of Suolé’s hypothesis. The latter suggests, inter
alia, that high coefficients of variation indicate a proportionately higher environmental than hereditary contribution to
phenotypic variation. Negative correlations between tooth size and coefficients of variation suggest that tooth-size variability
is related to size rather than occlusal complexity. 相似文献
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Normative odontometric data are presented on a sample of 66 adult thick-tailed bushbabies Otolemur crassicaudatus(34 male, 32 female). This species is characterized by low levels of sexual dimorphism, with univariate differences centered
on the canines and the maxillary third molar. Multivariate canonical analysis isolates a third discriminator, the maxillary
second molar. Stepwise discriminant analyses, performed after jackknifing, indicate high percentages of correct classification
(males, 79.8–81.8%;females, 81–85.2%). When variability profiles consisting of arrays of CVs are compared, males and females are found to share
similar patterns. Data for maxillary teeth offer support for Gingerich’s occlusal complexity model, while morphogenetic clusterings
within regressions of variability on tooth size conform to those previously reported in other species. These relationships
are lost in the mandibular dentition, suggesting an independence of upper from lower toothsize determination. 相似文献
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Nicotinic Agonists Regulate α-Bungarotoxin Binding Sites of TE671 Human Medulloblastoma Cells 总被引:1,自引:1,他引:0
The TE671 human medulloblastoma cell line expresses a variety of characteristics of human neurons. Among these characteristics is the expression of membrane-bound high-affinity binding sites for alpha-bungarotoxin, which is a potent antagonist of functional nicotinic acetylcholine receptors on these cells. These toxin binding sites represent a class of nicotinic receptor isotypes present in mammalian brain. Treatment of TE671 cells during proliferative growth phase with nicotine or carbamylcholine, but not with muscarine or d-tubocurarine, induced up to a five-fold increase in the density of radiolabeled toxin binding sites in crude membrane fractions. This effect was blocked by co-incubation with the nicotinic antagonists d-tubocurarine and decamethonium, but not by mecamylamine or by muscarinic antagonists. Following a 10-13 h lag phase upon removal of agonist, recovery of the up-regulated sites to control values occurred within an additional 10-20 h. These studies indicate that the expression of functional nicotinic acetylcholine receptors on TE671 cells is subject to regulation by nicotinic agonists. Studies of the murine CNS have consistently indicated nicotine-induced up-regulation of nicotinic acetylcholine receptors, thereby supporting the identification of the toxin binding site on these cells as the functional nicotinic receptor. Although a mechanism for this effect is not apparent, nicotine-induced receptor blockade does not appear to be involved. 相似文献
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A colostral protein that induces the growth and differentiation of resting B lymphocytes 总被引:5,自引:0,他引:5
We describe the first protein of mammalian origin that induces the growth and differentiation of resting B lymphocytes. A proline-rich protein has been isolated from sheep colostrum. A purified proline-rich protein preparation (PRPP) induced resting mouse B cells into and supported their progression through the cell cycle at frequencies comparable with those seen for LPS. Differentiation of resting B cells to plaque formation was also supported as efficiently by PRPP as it was by LPS. However, PRPP was distinct from LPS in that it supported the growth and differentiation of resting B cells derived from either C3H/Tif or C3H/HeJ mice. Splenocytes from neonatal mice responded robustly to PRPP with the growth and differentiation of contained B cells to plaque formation. Unlike LPS, PRPP did not induce detectable Ig isotype switching. 相似文献
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