Maternal Magnesium Restriction Elevates Glucocorticoid Stress and Inflammation in the Placenta and Fetus of WNIN Rat Dams

Magnesium plays a major role in many vital functions in the body. We reported earlier that maternal magnesium restriction altered body composition, fat metabolism, and insulin resistance in WNIN rat offspring and was associated with increased glucocorticoid stress in the offspring in their later life. We hypothesize that increased glucocorticoid stress and inflammation which originate in Mg restricted rat dams is transmitted through placenta to the fetus and underlie the metabolic disturbances in the later life of the offspring. Female weanling WNIN rats received ad libitum, a control diet (MgC) or the same with 62% restriction of Mg (MgR) for 3 months, and their plasma magnesium, inflammatory cytokines, and corticosterone were determined (n = 6 per group) before mating. Following mating with control males, placentae, and fetuses were collected on gestational day 15 (GD 15) from MgC and MgR dams (eight dams from each group and three samples from each dam) and used to determine the levels of inflammatory cytokines, corticosterone, and expression of relevant genes. MgR placentae and fetuses had higher (than MgC) levels of corticosterone and proinflammatory cytokines. Expression of Hsd11b1 was increased (sixfold, p < 0.05), while that of Hsd11b2 was decreased (0.4-fold, p < 0.05) in MgR (than MgC) placenta, whereas expression of Hsd11b1was increased (3.4-fold, p < 0.05) in MgR fetus. Chronic dietary magnesium restriction in WNIN female rats increased their levels of corticosterone, leptin, and proinflammatory cytokines which appeared to be transmitted through placenta to the fetus and could thus be associated with increased stress, altered body composition, fat metabolism, and insulin resistance in the later life of the offspring.     

“Canadian Experience” discourse and anti-racialism in a “post-racial” society

“Canadian Experience” is a paradox for many immigrants in Canada and contributes to their exclusion from the labour market. Through an analysis of Canadian English print media, from 2006 to 2011, we illustrate how “Canadian Experience” discourse places the responsibility of immigrant labour market integration on immigrants themselves and constructs their experiences of exclusion as non-racial. This is theorized as a “post-racial” strategy that relies on anti-racialism (avoidance of racial references) to deny the existence and effects of racism, thereby allowing the Canadian public to maintain its façade of innocence but perpetuates “racism without racists”. The discourse de-historicizes postcolonial racial hierarchy and promotes a de-racialized neo-liberal model for immigrant inclusion. This has implications for anti-racism and settlement service provision.