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Rao PV Gupta N Jayaraj R Bhaskar AS Jatav PC 《Comparative biochemistry and physiology. Toxicology & pharmacology : CBP》2005,140(1):11-19
Microcystins are naturally occurring hepatotoxins produced by certain strains of Microcystis aeruginosa and microcystin-LR is the most toxic among the 60 microcystin variants isolated so far. These toxins have been implicated in both human and livestock mortality. In the present study we evaluated the age-dependent hepatotoxic effects of microcystin-LR (MC-LR) in mice after intraperitoneal and oral route of exposure. For acute toxicity studies by intraperitoneal route, 1 LD(50) dose of MC-LR (43.0 microg/kg) was administered to 6- to 36-week-old mice. Results showed that time to death in toxin treated animals decreased with age of mice. In comparison to control mice, treated animals of all age groups showed significant increases in liver body mass index and increases in serum enzymes (lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, sorbitol dehydrogenase). For acute oral toxicity studies, 1 LD(50) of microcystin-LR containing extracts (3.5 g of MCE/kg) was administered to 6- and 36-week-old mice. The effects on biochemical variables were similar to intraperitoneal route of exposure. Significant age-dependent effects that were observed in microcystin treated animals by intraperitoneal and oral routes of exposure include: time to death, hepatic lipid peroxidation, glutathione depletion and DNA fragmentation. The age-dependent effects observed in some of the biochemical variables may be due to difference in the amount of microcystin-LR up take and also the age-dependent ability to detoxify the toxin in mice. 相似文献
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Flora SJ Mehta A Gautam P Jatav PC Pathak U 《Biological trace element research》2007,120(1-3):235-247
Thiols are known to act as protectants in the biological system for their involvement in a number of metabolic regulations.
In this study, we investigated the effect of a new and potent thiol-chelating agent, monoisoamyl 2,3-dimercaptosuccinic acid
(MiADMSA), an analog of meso 2,3-dimercaptosuccinic acid, to find out if it could act as a prooxidant (because of its lipophilic
character) or antioxidant (because of thiol moiety) that could supplement its chelating properties in different age groups
of male rats (young, adult, and old rats) and produce effective clinical recoveries in the treatment of metal intoxication.
Animals were treated with 25, 50, and 100 mg/kg of MiADMSA, i.p, once daily for 1 week to assess the effect on the antioxidant
system in major organs based on sensitive biochemical variables indicative of oxidative stress. Results suggested that MiADMSA
administration increased the activity of d-aminolevulinic acid dehydratase in all the age groups and increased blood glutathione (GSH) levels in young rats. MiADMSA
also potentiated the synthesis of metallothioneine in liver and kidneys and GSH levels in liver and brain. Apart from this
it also significantly reduced the glutathione disulfide levels in tissues. However, administration of MiADMSA caused some
concern over the copper loss. MiADMSA was found to be safe in rats of all ages. 相似文献
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Singhal Rajesh Kumar Jatav Hanuman Singh Aftab Tariq Pandey Saurabh Mishra Udit Nandan Chauhan Jyoti Chand Subhash Indu Saha Debanjana Dadarwal Basant Kumar Chandra Kailash Khan Mudasser Ahmed Rajput Vishnu D. Minkina Tatiana Narayana Eetela Sathya Sharma Manoj Kumar Ahmed Shahid 《Journal of Plant Growth Regulation》2021,40(6):2303-2328
Journal of Plant Growth Regulation - Nitric oxide (NO) is a free-radical gasotransmitter signaling molecule associated with a varied spectrum of signal transduction pathways linked to inducing... 相似文献
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