全文获取类型
收费全文 | 65746篇 |
免费 | 6653篇 |
国内免费 | 37篇 |
出版年
2022年 | 452篇 |
2021年 | 951篇 |
2020年 | 584篇 |
2019年 | 723篇 |
2018年 | 888篇 |
2017年 | 808篇 |
2016年 | 1320篇 |
2015年 | 2185篇 |
2014年 | 2443篇 |
2013年 | 3154篇 |
2012年 | 3925篇 |
2011年 | 4047篇 |
2010年 | 2622篇 |
2009年 | 2381篇 |
2008年 | 3331篇 |
2007年 | 3419篇 |
2006年 | 3264篇 |
2005年 | 3200篇 |
2004年 | 3095篇 |
2003年 | 2923篇 |
2002年 | 2794篇 |
2001年 | 1036篇 |
2000年 | 994篇 |
1999年 | 1066篇 |
1998年 | 931篇 |
1997年 | 749篇 |
1996年 | 656篇 |
1995年 | 618篇 |
1994年 | 604篇 |
1993年 | 618篇 |
1992年 | 857篇 |
1991年 | 797篇 |
1990年 | 782篇 |
1989年 | 722篇 |
1988年 | 686篇 |
1987年 | 620篇 |
1986年 | 598篇 |
1985年 | 644篇 |
1984年 | 681篇 |
1983年 | 582篇 |
1982年 | 636篇 |
1981年 | 654篇 |
1980年 | 542篇 |
1979年 | 552篇 |
1978年 | 531篇 |
1977年 | 473篇 |
1976年 | 503篇 |
1975年 | 397篇 |
1974年 | 444篇 |
1973年 | 458篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
The effects of 5-methoxy-N, N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolactin release in male rats was determined. Basal serum prolactin levels were not altered after administration of 1.0, 2.0, 5.0, 10.0 or 20.0 mg/kg of 5-MeODMT.Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic neurotransmission for part of their prolactin release stimulation. Prolactin release in response to L-5-hydroxytryptophan (5-HTP) or morphine was significantly reduced by pretreatment of the rats with 5-MeODMT.The results of this experiment indicate that 5-MeODMT act as a presynaptic serotonin autoreceptor stimulant and not as a postsynaptic serotonin agonist on the neuronal systems that control prolactin release. 相似文献
2.
L J Petterborg M K Vaughan L Y Johnson T H Champney R J Reiter 《Comparative biochemistry and physiology. A, Comparative physiology》1984,78(1):31-34
Exposure of male Syrian hamsters (Mesocricetus auratus) for 10 weeks to short photoperiod (SP) providing 10 hr light: 14 hr darkness (10:14 LD) produced a significant reduction in the weights of the reproductive organs, plasma thyroxine (T4) levels and free T4 index (FT4I) compared to the values of animals exposed to long photoperiod (LP, 14:10 LD). C57bl male house mice (Mus musculus) kept in SP (10:14 LD) had reproductive organ weights equivalent to those of mice kept in long days (14:10 LD) and lower T3 uptake (T3U) values. Male gerbils (Meriones unguiculatus) exposed to 13 weeks of SP (10:14 LD) had lower body weights, testes and seminal vesicle weights and higher T3U values compared to LP (14:10 LD) controls. However, no effect was seen on plasma T4 and triiodothyronine (T3) values nor the FT4I and free T3 index (FT3I). White-footed male mice (Peromyscus leucopus) exposed to SP (8:16 LD) had significantly lower testes and seminal vesicle weights while plasma T4 and T3 levels were unaffected. Snell strain house mice (Mus musculus) exposed to SP (8:16 LD) had normal reproductive organ weights compared to the values of LP-exposed (16:8 LD) control animals. However, there was a significant depression in T3 and in the FT3I in the SP animals. 相似文献
3.
The Fis protein: it''s not just for DNA inversion anymore 总被引:36,自引:0,他引:36
4.
(Z)- and (E)-4-amino-2-(trifluoromethyl)-2-butenoic acid (4 and 5, respectively) were synthesized and investigated as potential mechanism-based inactivators of gamma-aminobutyric acid aminotransferase (GABA-AT) in a continuing effort to map the active site of this enzyme. The core alpha-trifluoromethyl-alpha,beta-unsaturated ester moiety was prepared via a Reformatsky/reductive elimination coupling of the key intermediates tert-butyl 2,2-dichloro-3,3,3-trifluoropropionate and N,N-bis(tert-butoxy-carbonyl)glycinal. Both 4 and 5 inhibited GABA-AT in a time-dependent manner, but displayed non-pseudo-first-order inactivation kinetics; initially, the inactivation rate increased with time. Further investigation demonstrated that the actual inactivator is generated enzymatically from 4 or 5. This inactivating species is released from the active site prior to inactivation, and as a result, 4 and 5 cannot be defined as mechanism-based inactivators. Furthermore, 4 and 5 are alternate substrates for GABA-AT, transaminated by the enzyme with Km values of 0.74 and 20.5 mM, respectively. Transamination occurs approximately 276 and 305 times per inactivation event for 4 and 5, respectively. The enzyme also catalyzes the elimination of the fluoride ion from 4 and 5. A mechanism to account for these observations is proposed. 相似文献
5.
Herbert James Ilott 《BMJ (Clinical research ed.)》1887,2(1399):880-881
6.
7.
Puerto Rican populations of two species of sea anemones (Bunodosoma cavernata and B. granulifera) which had previously been considered one were assayed electrophoretically for enzymes encoded by 12 loci. The two species shared no common allozymes at 6 of the 12 loci. Genetic distance and identity values based on these allozymes were computed for the Puerto Rican populations and for B. cavernata from Florida and B. granulifera from Panama. The Puerto Rican populations of both species had much higher genetic identities for their geographically distant conspecifics than for each other. These results indicate that the two species are reproductively isolated and should be considered as separate valid species. Average heterozygosities are presented which are the first published for coelenterate species. 相似文献
8.
9.
10.