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1.
The role of the tubulin-microtubule system was examined in human peripheral blood leukocytes after activation with phytohemagglutinin (PHA). Soluble tubulin and microtubules were measured with a [(3)H]colchicine-binding assay. It was found that the tubulin content of PHA-activated lymphocytes was consistently increased relative to total protein content after 36 h of culture. There was no increase in the proportion of total tubulin synthesis which was present as microtubules at 36 h. Nevertheless, as a result of increased tubulin synthesis, there was a two-to three-fold increase in total microtubular mass. Colchicine, which disrupts microtubles, was used to assess the role of microtubule assembly in the sequence of events which follow lymphocyte activation, namely lymphokine release, protein synthesis, RNA synthesis, and DNA synthesis. Colchicine consistently inhibited DNA synthesis but did not inhibit release of the lymphokine, osteoclast activating factor (OAF). Protein and RNA syntheses were inhibited much less than DNA synthesis. The fact that some effects of PHA on lymphocytes appear to require intact microtubules and at least one does not suggest that the microtubule dependent step in PHA-stimulated lymphocyte activation occurs at a stage after propagation of the signal from the membrane to the cell interior. 相似文献
2.
Lee CT Hoopes MF Diehl J Gilliland W Huxel G Leaver EV McCann K Umbanhowar J Mogilner A 《Journal of theoretical biology》2001,210(2):201-219
In this paper, we consider local and non-local spatially explicit mathematical models for biological phenomena. We show that, when rate differences between fast and slow local dynamics are great enough, non-local models are adequate simplifications of local models. Non-local models thus avoid describing fast processes in mechanistic detail, instead describing the effects of fast processes on slower ones. As a consequence, non-local models are helpful to biologists because they describe biological systems on scales that are convenient to observation, data collection, and insight. We illustrate these arguments by comparing local and non-local models for the aggregation of hypothetical organisms, and we support theoretical ideas with concrete examples from cell biology and animal behavior. 相似文献
3.
Simulated brain tumor growth dynamics using a three-dimensional cellular automaton 总被引:10,自引:0,他引:10
Kansal AR Torquato S Harsh GR IV Chiocca EA Deisboeck TS 《Journal of theoretical biology》2000,203(4):367-382
We have developed a novel and versatile three-dimensional cellular automaton model of brain tumor growth. We show that macroscopic tumor behavior can be realistically modeled using microscopic parameters. Using only four parameters, this model simulates Gompertzian growth for a tumor growing over nearly three orders of magnitude in radius. It also predicts the composition and dynamics of the tumor at selected time points in agreement with medical literature. We also demonstrate the flexibility of the model by showing the emergence, and eventual dominance, of a second tumor clone with a different genotype. The model incorporates several important and novel features, both in the rules governing the model and in the underlying structure of the model. Among these are a new definition of how to model proliferative and non-proliferative cells, an isotropic lattice, and an adaptive grid lattice. 相似文献
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PIERRE‐OLIVIER ANTOINE KEVIN F. DOWNING JEAN‐YVES CROCHET FRANCIS DURANTHON LAWRENCE J. FLYNN LAURENT MARIVAUX GRÉGOIRE MÉTAIS ABDUL RAHIM RAJPAR GHAZALA ROOHI 《Zoological Journal of the Linnean Society》2010,160(1):139-194
Rhinocerotids are particularly abundant and diversified in Neogene deposits of the Indian subcontinent, but their systematics is far from being well defined. Based on the revision of old collections and new findings from the Early Miocene of the Bugti Hills and Zinda Pir, Pakistan, ‘Aceratherium blanfordi Lydekker, 1884’ is a chimera, consisting of two dentally convergent but postcranially distinct rhinocerotid taxa: Pleuroceros blanfordi and Mesaceratherium welcommi sp. nov. Postcranial features appear to be much more diagnostic than craniodental morphology in this case. A phylogenetic analysis based on 282 morphological characters scored for 28 taxa (four outgroups and ingroup including both taxa of interest and a ‘branching group’) strengthens this statement and supports Pleuroceros and Mesaceratherium as monophyletic genera within Rhinocerotinae. Both genera are recognized for the first time outside Europe. In the Bugti Hills, P. blanfordi and M. welcommi are part of an exceptionally diversified rhinocerotid fauna, with up to nine species associated in the same locality (Kumbi 4f). This rhinocerotid assemblage confirms the earliest Miocene age (Agenian/Aquitanian) of the upper member of the Chitarwata Formation as a whole. Coeval homotaxic rhinocerotid faunas from Europe (France, Czech Republic) and East Africa (Uganda, Kenya) support broad and sustainable rhinocerotid interchanges amongst South Asia, Europe, and Africa under compatible environmental conditions throughout earliest Miocene times. © 2010 The Linnean Society of London, Zoological Journal of the Linnean Society, 2010, 160 , 139–194. 相似文献
6.
Huxel GR 《Bulletin of mathematical biology》2007,69(6):2093-2104
The structure and dynamics of food webs are largely dependent upon interactions among consumers and their resources. However,
interspecific interactions such as intraguild predation and interference competition can also play a significant role in the
stability of communities. The role of antagonistic/synergistic interactions among predators has been largely ignored in food
web theory. These mechanisms influence predation rates, which is one of the key factors regulating food web structure and
dynamics, thus ignoring them can potentially limit understanding of food webs. Using nonlinear models, it is shown that critical
aspects of multiple predator food web dynamics are antagonistic/synergistic interactions among predators. The influence of
antagonistic/synergistic interactions on coexistence of predators depended largely upon the parameter set used and the degree
of feeding niche differentiation. In all cases when there was no effect of antagonism or synergism (a
ij
=1.00), the predators coexisted. Using the stable parameter set, coexistence occurred across the range of antagonism/synergism
used. However, using the chaotic parameter strong antagonism resulted in the extinction of one or both species, while strong
synergism tended to coexistence. Whereas using the limit cycle parameter set, coexistence was strongly dependent on the degree
of feeding niche overlap. Additionally increasing the degree of feeding specialization of the predators on the two prey species
increased the amount of parameter space in which coexistence of the two predators occurred. Bifurcation analyses supported
the general pattern of increased stability when the predator interaction was synergistic and decreased stability when it was
antagonistic. Thus, synergistic interactions should be more common than antagonistic interactions in ecological systems. 相似文献
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Calanus finmarchicus is a key‐structural species of the North Atlantic polar biome. The species plays an important trophic role in subpolar and polar ecosystems as a grazer of phytoplankton and as a prey for higher trophic levels such as the larval stages of many fish species. Here, we used a recently developed ecological niche model to assess the ecological niche (sensu Hutchinson) of C. finmarchicus and characterize its spatial distribution. This model explained about 65% of the total variance of the observed spatial distribution inferred from an independent dataset (data of the continuous plankton recorder survey). Comparisons with other types of models (structured population and ecophysiological models) revealed a clear similarity between modeled spatial distributions at the scale of the North Atlantic. Contemporary models coupled with future projections indicated a progressive reduction of the spatial habitat of the species at the southern edge and a more pronounced one in the Georges Bank, the Scotian Shelf and the North Sea and a potential increase in abundance at the northern edge of its spatial distribution, especially in the Barents Sea. These major changes will probably lead to a major alteration of the trophodynamics of North Atlantic ecosystems affecting the trophodynamics and the biological carbon pump. 相似文献
9.
A number of recent studies have been directed towards developing a more complete understanding of myxomycete ecology throughout
the world. However, the lack of comparative data obtained using standard methodologies makes the results of these studies
somewhat speculative. The objective of this investigation was to examine the evidence of macroecological patterns in myxomycete
assemblages in high-elevation areas of the northern Neotropics. For this, a series of study areas in Mexico, Guatemala, and
Costa Rica, as well as two external study areas (one in the United States and the other in Thailand), were selected to compare
the diversity-environment relationships exhibited by myxomycetes. Altogether, the 2592 moist chamber cultures prepared yielded
a total of 1377 myxomycete records, representing 89 different species. A trend of decreasing species richness with decreasing
latitude was observed for the species assemblages associated with the study areas in the Neotropics. As latitude increased,
species assemblages in the Neotropical study areas became increasingly similar to the temperate study area. The difference
in species richness between study areas in Mexico and Thailand, along with the results obtained for a series of macroclimatic
patterns evaluated in the study areas of the Neotropical region, suggests that forest structure plays an important role in
the structure of myxomycete assemblages. In contrast, soil chemical characteristics and the pH of the substrates present seem
to be indirectly related to the diversity estimators used for analysis, suggesting that they are probably more important at
a smaller ecological scale. 相似文献
10.
CRAIG R. WHITE DAVID BOERTMANN DAVID GRÉMILLET PATRICK J. BUTLER JONATHAN A. GREEN GRAHAM R. MARTIN 《Ibis》2011,153(1):170-174
Arctic seas have warmed and sea ice has retreated. This has resulted in range contraction and population declines in some species, but it could potentially be a boon for others. Great Cormorants Phalacrocorax carbo have a partially wettable plumage and seem poorly suited to foraging in Arctic waters. We show that rates of population change of Cormorant colonies around Disko Bay, Greenland, are positively correlated with sea surface temperature, suggesting that they may benefit from a warming Arctic. However, although Cormorant populations may increase in response to Arctic warming, the extent of expansion of their winter range may ultimately be limited by other factors, such as sensory constraints on foraging behaviour during long Arctic nights. 相似文献