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Tyler N. J. C. Hotvedt R. Blix A. S. Sørensen D. R. 《Acta veterinaria Scandinavica》1990,31(4):479-488
The sedative action of medetomidine (-ketamine) was studied in 12 captive Norwegian semidomesticated reindeer (NR), including 4 newborn calves, and in 7 free-living Svalbard reindeer (SR). Medetomidine, with or without ketamine, caused effective, reliable immobilization in NR. Doses of 50–200 µg/kg medetomidine alone or 30-125 µg/kg medetomidine combined with ⩾ 300 µg/kg ketamine induced complete immobilization, good muscle relaxation and persistent, deep sedation with little respiratory depression in NR; SR required higher doses. Atipamezole successfully antagonized medetomidine (-ketamine) resulting in rapid and persistent reversal of immobilization in all cases (NR and SR). Both medetomidine and atipamezole had wide safety margins and no conspicuous lasting side effects after reversal. 相似文献
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